Maternal perinatal depressive symptoms trajectories and impact on toddler behavior – the importance of symptom duration and maternal bonding

Fransson, Emma; Sörensen, Ferdinand; Kallak, Theodora Kunovac; Ramklint, Mia; Eckerdal, Patricia; Heimgärtner, Magdalena; Krägeloh‐Mann, Ingeborg; Skalkidou, Alkistis

doi:10.1016/j.jad.2020.04.003

Cited by 37 publications

(26 citation statements)

References 47 publications

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“…Perinatal depression, defined by the Diagnostic and Statistical Manual of Mental Disorders 5 ( DSM-5, 2013 ) as a major depressive disorder with peripartum onset, affects about 10% of women giving birth ( Woody et al, 2017 ). Perinatal depression comes with a high societal cost ( Bauer et al, 2016 ) with substantial consequences for the mother ( Slomian et al, 2019 ), the partner ( Cameron et al, 2016 ; Paulson and Bazemore, 2010 ) and the child ( Agnafors et al, 2013a , 2013b ; Fransson et al, 2020 ). Fluctuations in steroid hormonal levels ( Bloch et al, 2003 ), in hypothalamic–pituitary–adrenal-axis regulation of glucocorticoids ( Glynn et al, 2013 ; Hannerfors et al, 2015 ; Iliadis et al, 2015 ; Jolley et al, 2007 ) and alterations in oxytocin levels ( Skrundz et al, 2011 ; Stuebe et al, 2013 ) are some of the factors studied for identification of the underlying mechanism of perinatal depression.…”

Section: Introductionmentioning

confidence: 99%

Longitudinal assessment of inflammatory markers in the peripartum period by depressive symptom trajectory groups

Bränn

Skalkidou

Schwarz

et al. 2022

Brain, Behavior, & Immunity - Health

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Section: Introductionmentioning

confidence: 99%

Longitudinal assessment of inflammatory markers in the peripartum period by depressive symptom trajectory groups

Bränn

Skalkidou

Schwarz

et al. 2022

Brain, Behavior, & Immunity - Health

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“…Indeed, the disturbance of the prenatal environment by depressive symptoms has been linked to increased risk of preterm birth ( Fransson, Örtenstrand and Hjelmstedt, 2011 ). Notably, we and others have shown that maternal negative affect predicts increased inflammation in infants born preterm ( Fransson, Dubicke, et al., 2011 ; Orr, James and Blackmore Prince, 2002 ) and maternal depressive symptoms occurring in the prenatal period could be particularly important for future child development ( Fransson et al., 2020 ; Kallak et al., 2021 ).…”

Section: Pni Mechanisms Of Perinatal Depressionmentioning

confidence: 83%

Psychoneuroimmunology in the context of perinatal depression - Tools for improved clinical practice

Fransson

2021

Brain, Behavior, & Immunity - Health

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Maternal mental health spans in a temporary manner from pre-conception through the phases of pregnancy, childbirth, and the postpartum period (i.e., perinatal). The psychoneuroimmunology (PNI) field has made important contributions to the knowledge of the pathophysiology of poor perinatal mental health, but the PNI lens could be used more broadly to inform clinical practice. This review argues that PNI holds the key to several important aspects of variations in mental health for pregnant and postpartum women. This review describes existing knowledge from studies on immune activation in maternal depression during pregnancy and postpartum, and other important features such as stress reactivity, the microbiome, and its metabolites. The importance of objective measures for screening and prediction is discussed as well as the need for novel therapeutics to treat poor mental health in the perinatal period. The PNI framework could thus be further applied to inform research about the mechanisms of perinatal psychiatric morbidity, which could pave the way for future precision medicine for perinatal mental health issues.

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“…The antenatal period is also a time when up to 40% of postnatal depressive episodes begin [ 4 ], a condition with a global prevalence range of 0.5% to 60% [ 5 ]. The biopsychosocial impacts of pregnancy and birth as well as the transition to motherhood must be considered when treating perinatal depression [ 6 , 7 ] as there is a growing body of knowledge highlighting the positive association between maternal perinatal mental health problems and psychological disturbances in children and families [ 8 – 10 ].…”

Section: Introductionmentioning

confidence: 99%

Women with perinatal suicidal ideation–A scoping review of the biopsychosocial risk factors to inform health service provision and research

Bright

Doody²,

Tuohy³

2022

PLoS ONE

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Objectives This review aims to map the existing evidence on perinatal suicidal ideation, identify biopsychosocial risk factors associated with suicidal ideation and make recommendations for service provision and future research. Methods Scoping review guided by Arskey’s and O’Malley’s (2005) framework. Five academic databases (PsycINFO, MEDLINE, CINAHL, ASSIA and Academic Search Complete) were searched from 1st January 2009 to 1st April 2022. Studies were screened by title, abstract and full text against inclusion and exclusion criteria. Primary qualitative, quantitative and mixed-methods studies, written in English pertaining to perinatal suicidal ideation were included. Forty-one studies met the eligibility criteria, data were extracted and narratively synthesised. Findings are reported in accordance with the PRISMA-SR extension. Key conclusions Findings were mapped onto the biopsychosocial framework and include sleep deprivation, maternal age, pregnancy complications, mood disorders, intimate partner violence, childhood maltreatment/abuse, low socioeconomic status, alcohol and tobacco misuse, miscarriage/perinatal loss, birth trauma and sleep deprivation. The findings demonstrate that the biopsychosocial risk factors for perinatal suicidal ideation are varied and complex. Implications for practice The minimisation of women’s experiences may lead to detrimental consequences and there is a need for increased knowledge of mental health problems by those working with women in the perinatal period to ensure safety planning conversations occur with every woman meeting ‘at risk’ criteria.

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Maternal perinatal depressive symptoms trajectories and impact on toddler behavior – the importance of symptom duration and maternal bonding

Cited by 37 publications

References 47 publications

Longitudinal assessment of inflammatory markers in the peripartum period by depressive symptom trajectory groups

Longitudinal assessment of inflammatory markers in the peripartum period by depressive symptom trajectory groups

Psychoneuroimmunology in the context of perinatal depression - Tools for improved clinical practice

Women with perinatal suicidal ideation–A scoping review of the biopsychosocial risk factors to inform health service provision and research

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