Maternal PAPP-A Levels at 11 - 13 Weeks of Gestation Predict Foetal and Neonatal Growth

Gentile, M.; Schifano, Martina; Lunardi, Sara; Nanini, Chiara; Moscuzza, Francesca; Sergiampietri, Claudia; Ciantelli, Massimiliano; Monacci, Francesca; Boldrini, Antonio; Luchi, Carlo; Ghirri, Paolo

doi:10.4236/ojog.2015.56053

Cited by 4 publications

(4 citation statements)

References 30 publications

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“…This show that the birth weight, APGAR scores at 1 minute and at 5 minutes of the babies was not totally influenced by the circulating levels of the maternal AFP and PAPP-A. This was in contrast with the previous reports (Gentile et al, 2015). PAPP-A is a protease of IGFBP4 which acts as a binding protein for IGF-1 and a powerful inhibitor for IGF-1.…”

Section: Discussioncontrasting

confidence: 72%

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Impact of <i>Plasmodium falciparum</i> malaria infection on serum cortisol, adrenocorticotropic hormone, pregnancy associated plasma protein-A and alpha-fetoprotein in pregnant women at Nnewi

Ukibe¹,

Onyenekwe²,

Anojulu³

et al. 2019

Int. J. Bio. Chem. Sci

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The present study assessed the maternal cortisol, Adrenocorticotropic hormone (ACTH), Pregnancy associated plasma protein-A (PAPP-A) and alpha-fetoprotein (AFP) concentrations in malaria infected pregnant women. A total of 76 (40 apparently healthy pregnant and 36 malaria-infected pregnant) women aged 18-40 years were prospectively recruited. Early morning blood samples (5 ml) were collected from each subject at 1 st and 2 nd trimesters. 1 ml of whole blood was used for the diagnosis of P. falciparum malaria using malaria Plasmodium falciparum Rapid Test Device (RTD) and Giemsa stained thick blood smears for microscopic detection of P. falciparum parasites while the remaining 4 ml was centrifuged, separated and serum used for estimation of cortisol, ACTH, AFP and PAPP-A using ELISA-based method. The mean cortisol (125.80 ±30.80 ng/ml) and AFP (1.9 ±0.7 MoM) concentrations in malaria-infected pregnant women were significantly (p<0.05) higher than those of normal pregnant women (86.70 ±3.30 and 1.5 ±0.7 respectively). Malaria-infected pregnant women had higher percentage of low birth weight babies (27.8%), preeclampsia (11.1%), premature rupture of membrane (11.1%), preterm delivery (30.6%), miscarriages (27.8%) and low APGAR score at one minute (2.8%). This shows the possible impact of malaria infection on pregnancy and birth outcomes. The increased cortisol concentration in malaria infected pregnant women shows that malaria infection in pregnancy increases the stress pregnant women are exposed to but the placental defect associated with increased placental permeability to AFP is not related to the effect of the stress (cortisol) and thus does not influence birth outcomes.

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Section: Discussioncontrasting

confidence: 72%

“…PAPP-A is a protease of IGFBP4 which acts as a binding protein for IGF-1 and a powerful inhibitor for IGF-1. IGF-1 plays an important role in regulating fetal growth by controlling glucose and amino acids absorption in trophoblastic cells (Gentile et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Impact of <i>Plasmodium falciparum</i> malaria infection on serum cortisol, adrenocorticotropic hormone, pregnancy associated plasma protein-A and alpha-fetoprotein in pregnant women at Nnewi

Ukibe¹,

Onyenekwe²,

Anojulu³

et al. 2019

Int. J. Bio. Chem. Sci

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show abstract

“…A number of other studies (16, 22–28) have found positive associations between early PAPP-A and the baby’s birth weight, although this finding is not universal. (18, 29) Indeed we failed to find an association when analysing raw or minimally adjusted data.…”

Section: Discussionmentioning

confidence: 92%

Early Pregnancy-Associated Plasma Protein A Concentrations Are Associated With Third Trimester Insulin Sensitivity

Petry

Ong

Hughes

et al. 2017

The Journal of Clinical Endocrinology &Amp; Metabolism

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Context:First or early second trimester pregnancy-associated plasma protein A (PAPP-A) concentrations have previously been shown to be lower in women who subsequently develop gestational diabetes mellitus (GDM) and gestational hypertension.Objective:We therefore sought to investigate why circulating PAPP-A concentrations are related to the subsequent risk of GDM and gestational hypertension.Patients, Design, and Setting:We measured serum PAPP-A concentrations around week 15 of pregnancy and related these to indices derived from week 28 oral glucose tolerance tests and blood pressures across pregnancy in the Cambridge Baby Growth Study cohort.Results:Increased PAPP-A concentrations were associated with reduced GDM risk [odds ratio 0.623 (0.453, 0.856), P = 3.5 × 10−3, n = 777] and reduced mean arterial blood pressures (β = −0.202 to −0.177, P = 1.7 to 6.9 × 10−3, n = 347 to 355). They were also negatively associated with week 28 fasting (β = −0.149, P = 6.6 × 10−4, n = 777) and 60-minute (β = −0.188, P = 1.5 × 10−5, n = 777) oral glucose tolerance test glucose concentrations. These associations were underpinned by the strong associations between increased week 15 PAPP-A concentrations and decreased week 28 insulin resistance (homeostasis model assessment of insulin resistance: β = −0.319, P = 1.7 × 10−13, n = 768), as well as increased insulin secretion relative to insulin sensitivity (insulin disposition index: β = 0.202, P = 6.5 × 10−6, n = 731).Conclusions:These results suggest that links between PAPP-A concentrations in early pregnancy and subsequent glucose concentrations and blood pressures may be mediated by changes in insulin sensitivity (and secretion).

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“…Previous studies have shown that PAPPA is a biomarker that is decreased in the serum of women who present with FGR in the first trimester ( 15 , 16 ). Giudice et al have demonstrated that neonatal weights are associated with serum PAPPA levels lower than the 25th centile ( 17 ).…”

Section: Discussionmentioning

confidence: 99%

Placental expression of PAPPA, PAPPA-2 and PLAC-1 in pregnacies is associated with FGR

et al. 2018

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Fetal growth restriction (FGR) is a gynecological disorder of varying etiology. In the present study, an expression analysis of pregnancy-associated plasma protein A (PAPPA), pregnancy-associated plasma protein A2 (PAPPA2) and placenta-specific-1 (PLAC-1) was conducted in pregnancies with FGR and control pregnancies. Placental tissues were collected from pregnancies with FGR (n=16) and control pregnancies (n=16) and the expression of the genes of interest was examined by qPCR. The mean expression levels of PAPPA and PAPPA2 were significantly lower (P<0.001) in placental tissues from FGR pregnancies compared with tissues from healthy subjects, whereas the opposite pattern was observed for PLAC-1 (P<0.001). PAPPA and PLAC-1 expression in FGR and control subjects correlated with birth weight (P<0.001). The findings suggest a possible pathophysiological link between the development of FGR and the expression of PAPPA, PAPPA2 and PLAC-1.

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Maternal PAPP-A Levels at 11 - 13 Weeks of Gestation Predict Foetal and Neonatal Growth

Cited by 4 publications

References 30 publications

Impact of <i>Plasmodium falciparum</i> malaria infection on serum cortisol, adrenocorticotropic hormone, pregnancy associated plasma protein-A and alpha-fetoprotein in pregnant women at Nnewi

Impact of <i>Plasmodium falciparum</i> malaria infection on serum cortisol, adrenocorticotropic hormone, pregnancy associated plasma protein-A and alpha-fetoprotein in pregnant women at Nnewi

Early Pregnancy-Associated Plasma Protein A Concentrations Are Associated With Third Trimester Insulin Sensitivity

Placental expression of PAPPA, PAPPA-2 and PLAC-1 in pregnacies is associated with FGR

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