Maternal Pancreatic Carcinoma Metastatic to the Placenta: A Case Report and Literature Review

Al-Adnani, Mudher; Kiho, Liina; Scheimberg, Irene

doi:10.2350/06-06-0119.1

Cited by 39 publications

(28 citation statements)

References 13 publications

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“…Al-Adnani and colleagues [3] reviewed 81 cases of metastatic maternal tumors to the placenta and/or baby reported in the English language literature. We performed a comprehensive review of the English language literature and identified 32 other cases of fetal malignancy/TAM involving the placenta, with involvement specifically defined as circulating tumor cells and/or CV stromal infiltrates ( Table 1).…”

Section: Discussionmentioning

confidence: 99%

Trisomy 21–Associated Transient Abnormal Myelopoiesis Involving the Maternal Space of the Placenta: A Case Report and Literature Review

et al. 2014

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We report a case of a male newborn with trisomy 21 and transient abnormal myelopoiesis at birth whose placenta showed extravasated fetal blasts in the perivillous (maternal) space. Concern for possible maternal spread of fetal malignancy prompted a Kleihauer-Betke test and flow cytometric analysis of the maternal peripheral blood on postpartum day 2. Notably, no evidence of the persistence of fetal cells in the maternal blood was identified, a finding that likely reflected successful maternal immunologic clearance of the fetal blasts and erythrocytes, and/or blast cellular fragility and limited viability. Ours is the first report, to our knowledge, documenting maternal peripheral-blood follow-up evaluation of this disorder in the English literature. We discuss our case in the context of a comprehensive review of fetoneonatal solid tumor and leukemic proliferative disorders with placental involvement and evidence of maternal metastasis.

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Section: Discussionmentioning

confidence: 99%

Trisomy 21–Associated Transient Abnormal Myelopoiesis Involving the Maternal Space of the Placenta: A Case Report and Literature Review

et al. 2014

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“…Approximately 1 in 1000 to 1 in 1500 pregnancies is complicated by maternal malignant disease but well‐documented reports of maternal cancer metastatic to the placenta are rare, and metastatic to the fetus, exceptionally rare. A review published at the end of the 1980s reported that between 1866 and 1989, 52 cases had been published in the international literature107, with around 20 more cases reported in the last 20 years or so7, 8, 108–119. Malignant melanoma affects young individuals and spreads extensively via the vascular system, and is therefore the most common maternal neoplasm involving the placenta, accounting for about one third of cases98, 107, with carcinomas of breast and bronchus becoming increasingly common.…”

Section: Placental Malignancymentioning

confidence: 99%

Metal Ion Coordination to Azole Nucleosides

Müller

Böhme

Lax

et al. 2005

Chemistry A European J

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To evaluate the possibility of introducing azole nucleosides as building blocks for metal-mediated base pairs in artificial oligonucleotides, imidazole nucleoside, 1,2,4-triazole nucleoside and tetrazole nucleoside have been synthesized and characterized. The X-ray crystal structures of p-toluoyl-protected 1,2,4-triazole and tetrazole nucleosides are reported. Contrary to the situation primarily found for deoxyribonucleosides, the sugar moieties adopt C3'-endo conformations. The acidity of the beta nucleosides increases with increasing number of nitrogen ring atoms, giving pKa values of 6.01 +/- 0.05, 1.32+/-0.05 and <-3, respectively. This decrease in basicity results in a decreasing ability to form 2:1 complexes with linearly coordinating metal ions such as Ag+ and Hg2+. In all cases, the Ag+ complexes are of higher stability than the corresponding Hg2+ complexes. Whereas imidazole nucleoside forms highly stable 2:1 complexes with both metal ions (estimated log beta2 values of >10), only Ag+ is able to reach this coordination pattern in the case of triazole nucleoside (log beta2 = 4.3 +/- 0.1). Tetrazole nucleoside does not form 2:1 complexes at all under the experimental conditions used. These data suggest that imidazole nucleoside, and to a lesser extent 1,2,4-triazole nucleoside, are likely candidates for successful incorporation as ligands in oligonucleotides based on metal-mediated base pairs. DFT calculations further corroborate this idea, providing model complexes for such base pairs with glycosidic bond distances (10.8-11.0 Angstroms) resembling those in idealized B-DNA (10.85 Angstroms).

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“…[1–23] Table 1 summarizes the existing case reports of pancreatic neoplasms during pregnancy. These tumors present a diagnostic and therapeutic challenge when diagnosed antepartum.…”

Section: Discussionmentioning

confidence: 99%

“…There have been only eight reported cases of pancreatic adenocarcinoma,[1–8] thirteen cases of cystic pancreatic lesions diagnosed during pregnancy,[9–21] and three reported cases of pancreatic neuroendocrine tumors. [22, 23] Their occurrence during pregnancy leads to dilemmas in diagnosis, management, and timing of surgical treatment.…”

Section: Introductionmentioning

confidence: 99%

“…There have been several individual case reports on patients with pancreatic neoplasms in pregnancy,[1–23] the most common of which are mucinous cystic neoplasms (MCNs) and adenocarcinomas. MCNs of the pancreas have been described almost exclusively in women,[24–27] and their hormone-responsiveness and large size may contribute to their recognition during pregnancy.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pancreatic Neoplasms in Pregnancy: Diagnosis, Complications, and Management

Boyd

Benarroch‐Gampel

Kılıç

et al. 2012

Journal of Gastrointestinal Surgery

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BACKGROUND Neoplasms of the pancreas during pregnancy are rare, with less than 25 cases of benign and malignant tumors reported in the literature. METHODS We present three unique cases of pancreatic tumors occurring during pregnancy—one mucinous cystic neoplasm and two adenocarcinomas. We review the literature regarding pancreatic neoplasms during pregnancy and discuss the diagnosis, complications, and management of these tumors. RESULTS MRI and ultrasound are the imaging modalities of choice in pregnancy. In patients with benign or premalignant tumors, surgical resection may be postponed until the second trimester. In symptomatic patients, or if there is a concern for intrauterine growth restriction (IUGR), urgent surgical intervention should be performed. With malignant tumors, the benefit of delaying surgery must be balanced with the risk of maternal disease progression. Termination of the pregnancy should be discussed when a malignant tumor is diagnosed during the first trimester. Pancreatic tumors diagnosed during the third trimester may be resected after delivery. If malignant, early delivery of the fetus and subsequent maternal operation can be considered at appropriate fetal maturity. CONCLUSION When these tumors occur during pregnancy, they present a diagnostic and treatment dilemma, with variation in treatment based on gestational age and patient preference.

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Maternal Pancreatic Carcinoma Metastatic to the Placenta: A Case Report and Literature Review

Cited by 39 publications

References 13 publications

Trisomy 21–Associated Transient Abnormal Myelopoiesis Involving the Maternal Space of the Placenta: A Case Report and Literature Review

Trisomy 21–Associated Transient Abnormal Myelopoiesis Involving the Maternal Space of the Placenta: A Case Report and Literature Review

Metal Ion Coordination to Azole Nucleosides

Pancreatic Neoplasms in Pregnancy: Diagnosis, Complications, and Management

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