Maternal overweight and obesity are associated with increased risk of type 1 diabetes in offspring of parents without diabetes regardless of ethnicity

Hussen, Hozan Ismael; Persson, Martina; Moradi, Tahereh

doi:10.1007/s00125-015-3580-1

Cited by 65 publications

(83 citation statements)

References 42 publications

(56 reference statements)

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“…We performed these analyses to assess whether those factors have any influence on the observed associations, as they were found to be associated with type 1 diabetes in previous studies (19,21,22). We also repeated the Poisson models including only children.…”

Section: Additional Analysesmentioning

confidence: 99%

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Gestational Age and Birth Weight and the Risk of Childhood Type 1 Diabetes: A Population-Based Cohort and Sibling Design Study

et al. 2015

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OBJECTIVEWe investigated the effects of gestational age, birth weight, small for gestational age (SGA), and large for gestational age (LGA) on risk of childhood type 1 diabetes. RESEARCH DESIGN AND METHODSWe conducted a population-based cohort study of all singleton live births in Sweden between 1973 and 2009 and a sibling control study. Perinatal data were extracted from the Swedish Medical Birth Register. Children with type 1 diabetes diagnosis were identified from the Swedish National Patient Register. Log-linear Poisson regression and conditional logistic regression were used for data analysis. RESULTSThe study cohort consisted of 3,624,675 singleton live births (42,411,054 personyears). There were 13,944 type 1 diabetes cases during the study period. The sibling control study consisted of 11,403 children with type 1 diabetes and 17,920 siblings. Gestational age between 33 and 36 weeks (relative risk [RR] 1.18 [95% CI 1.09, 1.28) and 37 and 38 weeks (RR 1.12 [95% CI 1.07, 1.17]) was associated with type 1 diabetes in the cohort study and remained significant in the sibling control study. SGA (RR 0.83 [95% CI 0.75, 0.93]) and LGA (RR 1.14 [95% CI 1.04, 1.24]) were associated with type 1 diabetes in the cohort study. The SGA association remained unchanged in the sibling study, while the LGA association disappeared. Very low birth weight was associated with a reduced risk of type 1 diabetes. CONCLUSIONS

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Section: Additional Analysesmentioning

confidence: 99%

“…Maternal BMI is measured at the first antenatal visit, which takes place before 15 weeks' gestation in Sweden (19). Data on maternal education level were obtained from the Education Register, which contains information on the residents' highest level of completed formal education.…”

Section: Potential Confoundersmentioning

confidence: 99%

Gestational Age and Birth Weight and the Risk of Childhood Type 1 Diabetes: A Population-Based Cohort and Sibling Design Study

et al. 2015

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“…32 Other: Diabetes, Frequent Wheezing, Premature Menarche, Hospitalization Rates Although less well studied, there have been other adverse outcomes, including diabetes (both type 1 and type 2), asthma/ frequent wheezing, premature menarche, and increased hospitalization rates noted in children of obese mothers. In a large Swedish study Hussen et al 47 www.clinicalobgyn.com comparedwithoffspringofnormal-weight mothers, children of obese mothers who had been born in a Nordic country had a 25% higher risk for type 1 diabetes. In the same study, the authors reported that children born to obese mothers from nonNordic countries had a 67% higher risk for type 1 diabetes.…”

Section: Metabolic Syndrome (Ms)/ Cardiometabolic Laboratory Changesmentioning

confidence: 97%

The Effects of Maternal Obesity on Neonates, Infants, Children, Adolescents, and Adults

Hemond

Robbins

Young

2016

Clinical Obstetrics &Amp; Gynecology

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“…Maternal obesity is commonly seen in the United States and is considered as a strong predictor for a poor intrauterine environment and adverse outcomes for both the mother and child (Hussen et al, 2015). …”

Section: Maternal Diet Obesity and Epigeneticsmentioning

confidence: 99%

“…In addition, excess maternal nutrition is a predisposing factor for progeny to develop high birth weight and obesity in later life (Laraia et al, 2007), as well as the other severe adverse consequences, such as preterm birth, congenital defects, and perinatal death (Gaillard et al, 2013). A body of birth cohort studies demonstrates that over-nutrition during pregnancy increases the susceptibility to metabolic diseases in offspring later in life (Eriksson et al, 2014; Gaillard et al, 2014; Hussen et al, 2015). Thus, the effects of maternal obesity are particularly important for determining health outcome of the progeny ( Table 1 ).…”

Section: Maternal Diet Obesity and Epigeneticsmentioning

confidence: 99%

Epigenetic Mechanisms Link Maternal Diets and Gut Microbiome to Obesity in the Offspring

2018

Front. Genet.

106

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Nutrition is the most important environmental factor that can influence early developmental processes through regulation of epigenetic mechanisms during pregnancy and neonatal periods. Maternal diets or nutritional compositions contribute to the establishment of the epigenetic profiles in the fetus that have a profound impact on individual susceptibility to certain diseases or disorders in the offspring later in life. Obesity is considered a global epidemic that impairs human life quality and also increases risk of development of many human diseases such as diabetes and cardiovascular diseases. Studies have shown that maternal nutrition status is closely associated with obesity in progenies indicating obesity has a developmental origin. Maternal diets may also impact the early establishment of the fetal and neonatal microbiome leading to specific epigenetic signatures that may potentially predispose to the development of late-life obesity. This article will review the association of different maternal dietary statuses including essential nutritional quantity and specific dietary components with gut microbiome in determining epigenetic impacts on offspring susceptibility to obesity.

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Maternal overweight and obesity are associated with increased risk of type 1 diabetes in offspring of parents without diabetes regardless of ethnicity

Abstract: Increasing incidence of type 1 diabetes in children with non-diabetic parents may partly be explained by increasing prevalence of maternal overweight/obesity.

Cited by 65 publications

References 42 publications

Gestational Age and Birth Weight and the Risk of Childhood Type 1 Diabetes: A Population-Based Cohort and Sibling Design Study

Gestational Age and Birth Weight and the Risk of Childhood Type 1 Diabetes: A Population-Based Cohort and Sibling Design Study

The Effects of Maternal Obesity on Neonates, Infants, Children, Adolescents, and Adults

Epigenetic Mechanisms Link Maternal Diets and Gut Microbiome to Obesity in the Offspring

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