Maternal outcome in pregnancy with thrombocytopenia

Sojitra, Manthan; Shah, Sonal D.; Mehta, Ami V.; Panchal, Payal P.; Bhankhar, Ronak

doi:10.18203/2320-1770.ijrcog20202729

Cited by 3 publications

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“…In the present study, the mean age was 25.33±2.90 years and out of 150 women, 91 (60.7% of enrolled women) were living in rural areas. These observations were comparable to the study conducted by Sojitra et al [ 5 ]. Whereas in another study conducted by Gebreweld et al, the mean age was reported higher i.e.…”

Section: Discussionsupporting

confidence: 92%

Feto-Maternal Outcome in Pregnancy With Thrombocytopenia and Abnormal Platelet Indices

Mushahary,

Marwah,

Saran

et al. 2024

Cureus

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Background: Platelet count and its associated indices like mean platelet volume (MPV) and platelet distribution width (PDW) are cost-effective biomarkers that are easily accessible and have a potent role in the diagnosis and management of thrombocytopenia. Since anaemia and thrombocytopenia often go together in pregnancy, it is advisable to utilise these indices for feto-maternal benefit. Material and methods: The study was conducted in the Department of Obstetrics and Gynaecology at a tertiary care centre in New Delhi from July 2022 to December 2023 wherein pregnant women of age 18-40 years, period of gestation >28 weeks with thrombocytopenia or abnormal platelet indices were enrolled. Women with pancytopenia, bone marrow suppression or past or current SARS-CoV-2 positive status were excluded. Results: A total of 150 women were enrolled in the study. The mean age of study population was 25.33 ± 2.90 (range 19-34) years. Subjects were divided into three groups - Group A (mild thrombocytopenia) 24.6%, Group B (moderate thrombocytopenia) 64.6% and Group C (severe thrombocytopenia) 10.6% based on thrombocytopenia severity. Analysing the risk factors, Group C was found to have a significantly higher number of patients with anaemia (p=<0.001), fever (p=0.031), abnormal liquor volumes (p=0.004) and need for blood and platelet transfusion (p=0.077). On correlation of thrombocytopenia with abnormal platelet indices, it was observed that manual platelet count (MPC) and MPV were indirectly correlated (p=0.027). PDW was found to be directly associated with severe thrombocytopenia and indirectly associated with moderate thrombocytopenia. Conclusion: Thrombocytopenia in pregnancy is directly correlated to factors like maternal fever and anaemia, fetal growth restriction, abnormal liquor, blood products and platelet transfusions. It was also concluded that platelet indices like PDW and MPV play an important role in predicting the feto-maternal outcome and hence timely interventions can be done to improve the same.

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Section: Discussionsupporting

confidence: 92%

Feto-Maternal Outcome in Pregnancy With Thrombocytopenia and Abnormal Platelet Indices

Mushahary,

Marwah,

Saran

et al. 2024

Cureus

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“…In our study, Mean gestational age was 38.42 ± 1.69 weeks which was similar to studies conducted by Chauhan V et al [7] (38.6 ± 1.34weeks), Sojitra M et al [4] (38 weeks) and Lin et al [8] (39 weeks). Where as in the study by Bouzari et al [9] the mean age was 35.83 ± 3.61 weeks which was lower than our study.…”

Section: Discussionsupporting

confidence: 90%

“…In our study, Prevalence of thrombocytopenia was 6.67% which was comparable to study done by Sojitra M et al [4] (7.1%), Vyas et al [5] (7.6%), Burrows et al [6] (7.6%) and Chauhan V et al [7] (8.4%). Our prevelance was lower than other studies.…”

Section: Discussionsupporting

confidence: 89%

“…In our study maximum cases 71% belonged to gestational age 37 to 40 week which was similar to Parnas et al [10] . In our study, 53% women delivered vaginally and 47% had delivered by LSCS which was comparable, to study by Singh J et al [11] (vaginally 52% and LSCS 48%), Sojitra M et al [4] (vaginally 60% and LSCS 40%) and Vyas et al [5] (vaginally 63% and LSCS 37%) whereas the incidence of LSCS was higher in the studies conducted by pafumi et al 12(55%) and Yuce et al [13] (56%). In our study, 42% patients needed blood & blood products transfusion and 58% patients needed no transfusion.…”

Section: Discussionsupporting

confidence: 88%

“…19(36.10%). In our study, out of 102 neonates, Neonatal mortality were found in 3.92%(4) neonates which is comparable to the study of Parnas M et al in which 2.5% patients had neonatal death. In study by Katke RD et al 78 neonatal deaths occurred in 8.7% patients which higher than our study.…”

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confidence: 90%

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Maternal and fetal outcome among pregnant women presenting with thrombocytopenia

Kumari¹,

Sharma²,

Rajkumar³

2022

Int. J. Clin. Obstet. Gynaecol.

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Background: Thrombocytopenia is defined as platelet count less than 150000/μL.1,2 It is second only to anemia as the most common haematological abnormality encountered during pregnancy. Thrombocytopenia is encountered in 7-8% of all pregnancies but when patient's obstetric and medical condition are excluded, incidence down to 5.1%. Methods: This prospective observational study was conducted in the department of Obs & Gynae at Government Medical College & J. K. Lon hospital, Kota over a period of 1 year. Out of 2897 women, 1500 women willing to participate in the study and fulfilled our inclusion criteria. Out of 1500 women screened,100 women were found to have thrombocytopenia. Results: Prevalence of thrombocytopenia was 6.67%. The distribution of thrombocytopenia with etiology is 56% with gestational thrombocytopenia,35% including pre-eclampsia, HELLP syndrome, eclampsia, gestational hypertension and superimposed pre-eclampsia and 9% including DIC, ITP, Dengue and Malaria and hypersplenism. Mean gestational age was 38.42±1.69 weeks.53% women delivered vaginally and 47% had delivered by LSCS. 42% patients needed blood and blood products transfusion and 58% patients no blood transfusion. Newborn 76.47% (78) had normal birth weight and 23.53% (24) had low birth weight with mean birth weight 2.58±0.49kg.33(31.35%) neonates required NICU admission and 68.65% (69) newborns were healthy. Out of 102 neonates, 94.12% (96) had normal platelet count and 5.88%(6) had thrombocytopenia. Neonatal mortality3.92% (4) neonates. Conclusions: Most common cause of thrombocytopenia during pregnancy was gestational thrombocytopenia but other underlying causes must be considered as well. A careful examination and simple laboratory test are needed so that a serious condition that may require specific and urgent management (examples HELLP syndrome, severe pre-eclampsia, TTP, HUS, AFLP) is not missed. Management of pregnant women with platelet disorders requires a multidisciplinary approach.

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“Maternal Outcome in Pregnancy With Thrombocytopenia”

Jain¹,

Gupta²,

Jain

2021

ijsr

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INTRODUCTIONThrombocytopenia is diagnosed when the platelet count is less than 1,50,000 per microliter of blood It is a common hematological disorder Thrombocytopenia is divided into 3 types according to severity: mild (100,000 to 150,000), moderate (50,000to100,000) and severe (less than 50,000) thrombocytopenia. MATERIALAND METHODObjective- To study the incidence of thrombocytopenia in normal pregnancy. to study the maternal and fetal outcomes in pregnant patients with thrombocytopenia This is a retrospective study in which a total of 1202 patients delivered in a maternity hospital of Gwalior from 1 January 2018 to 30 June 2019 were studied. 72 patients with a platelet count below 1.5 lakhs were included in the study. RESULTSA total of 1202 patients were delivered during the study period out of the 72 patient had thrombocytopenia thus the prevalence was found to be 5.99%. rd In our study majority of the patients were multigravida 63.88% in the 3 trimester 54.16% majority by between age of 25-30 years 58.33%. In our study 61.11% of women had mild, 27.77 had moderate and 11.11% had severe thrombocytopenia. In this study, gestational thrombocytopenia was the most common etiological factor with 29.16% of cases. In our study, 70.83% of patients were delivered vaginally and 29.16% of patients were delivered by LSCS. No complication was reported in 48.61% of patients. The bleeding during CS was found in 4.16% cases, maternal hemorrhage was found in 5.55%, pulmonary edema in 5.55%, ARF in 5.55%, DIC 4.16%, and Puerperal sepsis in 2.77%. Blood transfusion was needed in 15.27% of patients, platelet transfusion in 4.16% of patients. Obstetric hysterectomy was done in 1 patient. During the study, 2 maternal death were reported due to the HELLPsyndrome and associated complications. CONCLUSIONGestational thrombocytopenia is the most common cause of thrombocytopenia during pregnancy. We conclude that early diagnosis of thrombocytopenia in pregnancy is essential for better maternal and fetal outcomes. It is important to determine the exact etiological cause of thrombocytopenia so that timely management can be provided to the pregnant patients to decrease the complication rate thus, timely diagnosis, frequent monitoring, and treatment is must achieve a better outcome.

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Maternal outcome in pregnancy with thrombocytopenia

Cited by 3 publications

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Feto-Maternal Outcome in Pregnancy With Thrombocytopenia and Abnormal Platelet Indices

Feto-Maternal Outcome in Pregnancy With Thrombocytopenia and Abnormal Platelet Indices

Maternal and fetal outcome among pregnant women presenting with thrombocytopenia

“Maternal Outcome in Pregnancy With Thrombocytopenia”

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