Maternal ophthalmic artery Doppler velocimetry in normotensive pregnancies and pregnancies complicated by hypertensive disorders

Hata, Toshiyuki; Hata, Kohkichi; Moritake, Kouzo

doi:10.1016/s0002-9378(97)70458-7

Cited by 61 publications

(79 citation statements)

References 9 publications

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“…14 On the other hand, studies have reported lower ophthalmic artery resistance in patients with severe preeclampsia, especially those with headache and visual symptoms. [17][18][19] The aim of this study was to investigate the association between ophthalmic artery resistive index (OARI) and clinical evidence of PRES in severe preeclampsia.…”

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confidence: 99%

Ophthalmic Artery-Resistive Index and Evidence of Overperfusion-Related Encephalopathy in Severe Preeclampsia

et al. 2010

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confidence: 99%

Ophthalmic Artery-Resistive Index and Evidence of Overperfusion-Related Encephalopathy in Severe Preeclampsia

et al. 2010

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“…The utilization of such index plays a relevant role in the differential diagnosis between PE and chronic arterial hypertension. Patients with chronic arterial hypertension tend to present OARI results similar to those of normotense pregnant women (19) . Considering that the differentiation between chronic arterial hypertension and PE, either by clinical or by laboratory means, is not always simple, dopplerfluxo-Radiol Bras.…”

Section: Discussionmentioning

confidence: 92%

Dopplerfluxometria de artérias oftálmicas e avaliação da função endotelial nas formas precoce e tardia da pré-eclâmpsia

Brandão¹,

Barbosa

Lopes

et al. 2012

Radiol Bras

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Objective: To identify possible differences between endothelial dysfunction evaluated by brachial artery flow-mediated dilation and central hyperperfusion evaluated by dopplerfluxometry of ophthalmic artery in women with early-and lateonset preeclampsia. Materials and Methods: Flow-mediated dilation testing and dopplerfluxometry of ophthalmic artery were performed in 81 patients (26 with early preeclampsia, 30 with late preeclampsia, and 25 normotensive pregnant women -control group). Results: As compared with the control group, patients with preeclampsia presented lower values of flow-mediated dilation, both in cases of early preeclampsia (7.62 ± 5.42% × 14.12 ± 6.14%; p = 0.02) and in cases of late preeclampsia (5.83 ± 4.12% × 14.12 ± 6.14%; p = 0.00). No statistically significant difference was observed between early-and late-onset preeclampsia (7.62 ± 5.42% × 5.83 ± 4.12%; p = 0.09). Values for dopplerfluxometry of ophthalmic artery were significant lower in patients with preeclampsia as compared with the control group, both in cases of early preeclampsia (0.631 ± 0.024 × 0.737 ± 0.032; p = 0.01) and in cases of late preeclampsia (0.653 ± 0.019 × 0.737 ± 0.032; p = 0.03). Again, no statistically significant difference was observed between early-and late-onset preeclampsia (0.631 ± 0.024 × 0.653 ± 0.019; p = 0.12). Basically, the results demonstrate a decrease in values for dopplerfluxometry of ophthalmic artery in patients with early and late presentations of preeclampsia as compared with the control group, although with no statistically significant difference between the two presentations of the disease. Conclusion: The present results indicate the presence of endothelial dysfunction and central hyperperfusion in patients with early-and late-onset preeclampsia. Keywords: Preeclampsia; Flow-mediated dilation; Ophthalmic arteries.Objetivo: Avaliar possíveis diferenças entre a disfunção endotelial, avaliada pela dilatação fluxo-mediada, e hiperperfusão central, avaliada por dopplerfluxometria da artéria oftálmica, entre pacientes portadoras da forma precoce e tardia da pré-eclâmpsia. Materiais e Métodos: O teste de dilatação fluxo-mediada e a dopplerfluxometria da artéria oftálmica foram obtidos de 81 gestantes, sendo 56 portadoras de pré-eclâmpsia (26 na forma precoce e 30 na forma tardia) e 25 gestantes saudáveis (grupo controle). Resultados: Portadoras de pré-eclâmpsia apresentaram valores menores de dilatação fluxo-mediada quando comparadas ao grupo controle, tanto na forma precoce (7,62 ± 5,42% × 14,12 ± 6,14%; p = 0,02) como na forma tardia (5,83 ± 4,12% × 14,12 ± 6,14%; p = 0,00). Não houve diferença quando foram comparadas as duas formas (7,62 ± 5,42% × 5,83 ± 4,12%; p = 0,09). A dopplerfluxometria da artéria oftálmica apresentou-se significativamente menor nas pacientes portadoras de pré-eclâmpsia quando comparadas ao grupo controle, tanto na forma precoce (0,631 ± 0,024 × 0,737 ± 0,032; p = 0,01) como na forma tardia (0,653 ± 0,019 × 0,737 ± 0,032; p = 0,03). Não houve diferença entre as duas formas ...

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“…It is easy to perform, noninvasive, and inexpensive. 7,[14][15][16][17] For a method to be valid, it must have no statistically significant intraobserver or interobserver variability. Reproducibility is one of the main principles of scientific methods.…”

Section: Resultsmentioning

confidence: 99%

“…The Doppler sample volume was adjusted at 2 to 3 mm. 1,2,5,7,[13][14][15][16][17]27 The participants were examined in the supine position by each observer. Gel was applied to the closed eyelid, and the transducer was carefully placed on the eyelid to avoid creating pressure-derived artifacts.…”

Section: Methodsmentioning

confidence: 99%

“…After 6 consecutive blood flow velocity waveforms with similar sizes and shapes were obtained, measurements were performed on a single waveform (Figure 1). 1,2,5,7,[13][14][15][16][17] The resistive index, pulsatility index, and peak ratio were measured. The peak ratio was defined as the ratio of the flow velocity of the second peak (after the notch) to that of the initial peak (peak systolic velocity; (peak ratio = peak 2/peak 1; Figure 1).…”

Section: Methodsmentioning

confidence: 99%

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Doppler Velocimetry of the Ophthalmic Artery

Oliveira

Sá

Velarde

et al. 2012

Journal of Ultrasound in Medicine

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Doppler Velocimetry of the Ophthalmic Arteryrbital circulation has been assessed by color Doppler imaging for the last 20 years, and patterns of normality have been described for the orbital vessels. The importance of this examination was first shown in ophthalmologic diseases. 1-3 Hata et al 4 were the first to use Doppler velocimetry of the ophthalmic artery in the assessment of pregnant women. Then several authors evaluated this method during pregnancy, especially in patients with hypertension. 5-17 Ocular Doppler sonography has been shown to be an accurate, objective, and promising method in the evaluation of the severity of preeclampsia, which is the major cause of maternal mortality. [18][19][20] Although several authors have published data for ocular Doppler velocimetry, the reliability of the measurement of ophthalmic Doppler indices (resistive index, pulsatility index, and peak ratio) has not been extensively established. Most studies have evaluated the intraobserver reproducibility. [21][22][23][24][25][26] This study aimed to investigate the interobserver reliability in measuring ophthalmic artery Doppler indices. ORIGINAL RESEARCHObjectives-The aim of this study was to investigate the interobserver reliability for measuring ophthalmic artery Doppler indices.Methods-Healthy women (n = 30) were evaluated. The resistive index, pulsatility index, and peak ratio were determined by two independent observers who were blind to each other. A paired t test was used for the comparison of paired samples in the cases of replication between observers. Pearson product-moment correlation was used to study the relationship between the samples. The Bland-Altman graphic approach was used to investigate the agreement between observers.Results-No significant differences were found between the values obtained by the two independent observers for the resistive index and pulsatility index. The difference observed between the values obtained by the observers for the peak ratio was 0.02.Conclusions-Doppler velocimetry is a reproducible technique for evaluation of the resistive index and pulsatility index. For analysis of the peak ratio, an interval of ±0.02 should be considered for the measurement.

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Maternal ophthalmic artery Doppler velocimetry in normotensive pregnancies and pregnancies complicated by hypertensive disorders

Cited by 61 publications

References 9 publications

Ophthalmic Artery-Resistive Index and Evidence of Overperfusion-Related Encephalopathy in Severe Preeclampsia

Ophthalmic Artery-Resistive Index and Evidence of Overperfusion-Related Encephalopathy in Severe Preeclampsia

Dopplerfluxometria de artérias oftálmicas e avaliação da função endotelial nas formas precoce e tardia da pré-eclâmpsia

Doppler Velocimetry of the Ophthalmic Artery

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