Maternal ophthalmic artery Doppler ultrasonography in preeclampsia and pregnancy outcomes

Chaves, Maria Teresa Pedrazzi; Costa, Sérgio Hofmeister de Almeida Martins; Oppermann, Maria; Dias, Ricardo Palma; Peña, Julio Alejandro; Ramos, José Geraldo Lopes

doi:10.1016/j.preghy.2017.10.006

Cited by 12 publications

(2 citation statements)

References 20 publications

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“…Only two other studies have assessed the use of ophthalmic artery Doppler in predicting adverse outcome in women with established PE. One of these studies, on 56 cases, demonstrated that the PSV ratio had an AUC of 0.82 (95% CI, 0.72-0.93) for the prediction of adverse maternal outcomes 44 . The second study, of 100 women, showed that the ophthalmic artery RI had a reasonable predictive value for adverse maternal outcomes (AUC, 0.82 (95% CI, 0.74-0.90)) 45 .…”

Section: Comparison With the Literaturementioning

confidence: 99%

Role of placental, fetal and maternal cardiovascular markers in predicting adverse outcome in women with suspected or confirmed pre‐eclampsia

Reddy

Palmer

Rolnik

et al. 2022

Ultrasound in Obstet & Gyne

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What are the novel findings of this work?In this prospective cohort study, we have demonstrated that, in women with suspected or confirmed pre-eclampsia, the soluble fms-like tyrosine kinase-1/placental growth factor (sFlt-1/PlGF) ratio performs well in predicting adverse perinatal outcome but not in predicting adverse maternal outcome. The use of maternal cardiovascular and fetal indices in addition to sFlt-1/PlGF ratio does not improve prognostic performance. What are the clinical implications of this work?There is a potential role for the sFlt-1/PlGF ratio in clinical practice, in which it may be used to stratify women with suspected or confirmed pre-eclampsia according to perinatal risk. However, given that this marker performs poorly in predicting maternal complications, its role in the management of women with diagnosed pre-eclampsia remains unclear.

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Section: Comparison With the Literaturementioning

confidence: 99%

Role of placental, fetal and maternal cardiovascular markers in predicting adverse outcome in women with suspected or confirmed pre‐eclampsia

Reddy

Palmer

Rolnik

et al. 2022

Ultrasound in Obstet & Gyne

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“…8 Several studies have described changes in the velocity wave pattern of the ophthalmic artery in women with PE, both prenatally and in the postpartum, with signs of decreased impedance and orbital hyperperfusion, represented by high values of peak ratio (PR), the second peak of systolic velocity (P2) and decreased resistance index (RI) and pulsatility index (PI). [9][10][11][12][13][14][15][16][17][18][19] However, there is no consensus in the literature about what is the best diagnostic parameter of OAD in pregnant women with PE. The aid of this ultrasound examination may be relevant if used in the hospital environment to diagnose patients with PE where this information is urgently needed, to optimize care and facilitate early treatment, especially in severe cases.…”

Section: Introductionmentioning

confidence: 99%

Ophthalmic artery Doppler in the complementary diagnosis of preeclampsia: a systematic review and meta-analysis

Melo

Roever

Mendonça

et al. 2022

Preprint

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Objective: To evaluate the accuracy of different parameters of the ophthalmic artery Doppler (OAD) in the complementary diagnosis of preeclampsia (PE).Methods: To investigate the mean difference in OAD values, peak systolic velocity (PSV), end-diastolic velocity (EDV), second systolic velocity peak (P2), resistance index (RI), pulsatility index (PI), and peak ratio (PR), between PE cases (overall and according to severity) and controls, random-effects meta-analyses were conducted for each Doppler parameter, with overall PE, mild and severe PE subgroups. Diagnostic performance and heterogeneity were evaluated with summary receiver-operating characteristics curves (sROC) and 95% confidence regions, obtained with bivariate modelsResults: Eight studies stratified the results in mild and severe or late and early PE, involving 1,425 pregnant women. PR and P2 had better diagnostic performance than the other indexes, with the PR of AUsROC at 0.885, the sensitivity of 84%, and specificity of 92%, with a low false-positive rate of 0.08 and the P2 with AUsROC of 0.926, the sensitivity of 85% and specificity of 88%. RI, PI, and EDV showed good performance and consistency across studies, but lower AUsROC of 0.833, 0.794, and 0.772, respectively.Conclusion: Ophthalmic artery Doppler is a complementary tool with good performance for diagnosis of overall and severe preeclampsia, with high and best sensitivity and specificity when using PR and P2 parameters.

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What Is the Role of the Maternal Ophthalmic and Cervical Internal Carotid Arteries in Predicting Maternal Adverse Outcomes in Preeclampsia?

Özdemir

Demirci

Akay

et al. 2020

J of Ultrasound Medicine

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ObjectivesWe aimed to investigate the efficacy of maternal ophthalmic artery (OA) and cervical internal carotid artery (CICA) in predicting adverse maternal outcomes and gestational age at birth in preeclampsia (PE).MethodsThe study was performed at the Zeynep Kamil Women and Children's Diseases Training and Research Hospital. Measurements were made in 2 groups consisting of 50 pregnant women with PE and 50 healthy pregnant women. The peak systolic velocity (PSV), end‐diastolic velocity, PI, RI, first diastolic peak velocity, systolic/diastolic (S/D) ratio, and peak ratio of the maternal OA were measured by a transorbital Doppler ultrasound (US) scan. The PSV, end‐diastolic velocity, PI, RI, and S/D ratio of the CICA were measured. The differences of Doppler indices between groups with P < .05 were considered statistically significant. Cutoff values were calculated, which could be used to predict adverse maternal outcomes and gestational age at birth.ResultsThe RI and PI values of the OA were lower, and the first diastolic peak velocity, PSV, and peak ratio values were higher among the PE group. The RI and S/D values of the CICA were significantly lower in the PE group compared to the healthy group. The OA RI was determined to be the strongest US variable in predicting adverse maternal outcomes and gestational age at birth, with a cutoff value of 0.72, 76% sensitivity, and 76% specificity.ConclusionsMaternal OA Doppler indices can be used as US markers to predict adverse maternal outcomes.

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Maternal ophthalmic artery Doppler ultrasonography in preeclampsia and pregnancy outcomes

Cited by 12 publications

References 20 publications

Role of placental, fetal and maternal cardiovascular markers in predicting adverse outcome in women with suspected or confirmed pre‐eclampsia

Role of placental, fetal and maternal cardiovascular markers in predicting adverse outcome in women with suspected or confirmed pre‐eclampsia

Ophthalmic artery Doppler in the complementary diagnosis of preeclampsia: a systematic review and meta-analysis

What Is the Role of the Maternal Ophthalmic and Cervical Internal Carotid Arteries in Predicting Maternal Adverse Outcomes in Preeclampsia?

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