Maternal Omega-3 Supplementation During Pregnancy, but Not Childhood Supplementation, Reduces the Risk of Food Allergy Diseases in Offspring

Huynh, Linh Ba Phuong; Nguyen, Nam Nhat; Fan, Hsien-Yu; Huang, Shih‐Yi; Huang, Chunling; Chen, Yang Ching

doi:10.1016/j.jaip.2023.06.005

Cited by 3 publications

(3 citation statements)

References 41 publications

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“…A meta-analysis study concluded that omega-3 supplementation during pregnancy reduces the risk of FA in children. On the other hand, omega-3 supplementation during childhood did not show any beneficial effects [134].…”

Section: Dietary Supplementsmentioning

confidence: 96%

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Update on In Vitro Diagnostic Tools and Treatments for Food Allergies

Brasal-Prieto,

Fernández-Prades,

Dakhaoui

et al. 2023

Nutrients

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Food allergy (FA) is an adverse immunological reaction to a specific food that can trigger a wide range of symptoms from mild to life-threatening. This adverse reaction is caused by different immunological mechanisms, such as IgE-mediated, non-IgE-mediated and mixed IgE-mediated reactions. Its epidemiology has had a significant increase in the last decade, more so in developed countries. It is estimated that approximately 2 to 10% of the world’s population has FA and this number appears to be increasing and also affecting more children. The diagnosis can be complex and requires the combination of different tests to establish an accurate diagnosis. However, the treatment of FA is based on avoiding the intake of the specific allergenic food, thus being very difficult at times and also controlling the symptoms in case of accidental exposure. Currently, there are other immunomodulatory treatments such as specific allergen immunotherapy or more innovative treatments that can induce a tolerance response. It is important to mention that research in this field is ongoing and clinical trials are underway to assess the safety and efficacy of these different immunotherapy approaches, new treatment pathways are being used to target and promote the tolerance response. In this review, we describe the new in vitro diagnostic tools and therapeutic treatments to show the latest advances in FA management. We conclude that although significant advances have been made to improve therapies and diagnostic tools for FA, there is an urgent need to standardize both so that, in their totality, they help to improve the management of FA.

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Section: Dietary Supplementsmentioning

confidence: 96%

“…Arachidonic and docosahexaenoic acids (PUFAs): mother during suckling period levels [133]. Omega-3 supplementation: mothers during pregnancy [134].…”

Section: Dietary Supplementsmentioning

confidence: 99%

Update on In Vitro Diagnostic Tools and Treatments for Food Allergies

Brasal-Prieto,

Fernández-Prades,

Dakhaoui

et al. 2023

Nutrients

View full text Add to dashboard Cite

show abstract

“…Explained by PUFAs, they have shown that in an in vivo FA mouse model, they modulated the activity of basophils in the sensitization phase of allergy and subsequent Th2 cytokine release [ 79 , 80 ]. Regarding this, supplementation in the diet with omega-3 fatty acids during pregnancy has influenced the development of FA in offspring and has played a role in the immune system as an anti-inflammatory agent, providing cell membrane stabilization with inhibition of antigen presentation in FA [ 81 , 82 , 83 ]. Indeed, a study has shown that a diet rich in these PUFAs helps reduce adverse effects in children with fish allergies [ 84 ].…”

Section: Nutraceuticals and Food Allergy (Fa)mentioning

confidence: 99%

Modulation of the Immune Response to Allergies Using Alternative Functional Foods

López-Enríquez,

Múnera-Rodríguez,

Leiva-Castro

et al. 2023

IJMS

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Modulation of the allergic immune response through alternative therapies is a field of study that aims to address allergic reactions differently from traditional approaches. These therapies encompass the utilization of natural functional foods, which have been observed to exert an influence on the immune response, thus mitigating the severity of allergies. Indeed, some studies suggest that the incorporation of these nutraceuticals can regulate immune function, leading to a reduction in histamine release and subsequent alleviation of allergic symptoms. Moreover, certain herbs and dietary supplements, such as curcumin, are believed to possess anti-inflammatory properties, which may serve to moderate allergic responses. Although the results remain somewhat mixed and require further research, these alternative therapies exhibit the potential to impact the allergic immune response, thereby providing complementary options to conventional treatments. Therefore, in this review, we aim to provide an updated account of functional foods capable of modulating the immune response to allergies. In that sense, the review delves into functional foods sourced from plants (phytochemicals), animals, and marine algae. Emphasis is placed on their potential application in the treatment of allergic disorders. It also provides an overview of how these foods can be effectively utilized as functional foods. Additionally, it explores the molecular mechanisms and scientific validity of various bioactive natural compounds in the management of allergies.

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Maternal allergy‐preventive diet index, offspring infant diet diversity, and childhood allergic diseases

Venter,

Pickett‐Nairne,

Leung

et al. 2024

Allergy

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BackgroundStudies of childhood diet diversity and allergic disease have not examined additional associations with an offspring allergy‐linked maternal diet index during pregnancy. We studied both associations in a pre‐birth cohort.MethodsOffspring allergic disease diagnoses were obtained from electronic medical records. Maternal and infant diet were self‐reported. Adjusted parametric Weibull time‐to‐event models assessed associations between maternal diet index, infant diet diversity and time to development of allergic rhinitis, atopic dermatitis, asthma, wheeze, IgE‐mediated food allergy, and a combined outcome of any allergic disease except for wheeze.ResultsInfant diet diversity at 1 year was associated with the risk of the combined outcome between 1 and 4 years of age (p = .002). While both maternal diet index and infant diet diversity at 1 year were associated with the risk of the combined outcome between 1 and 4 years of age (both p < .05), infant diet diversity at 1 year did not modify the association between maternal diet index and the risk of the combined outcome between 1 and 4 years of age (p = .5). The group with the lowest risk of the combined allergy outcome had higher maternal diet index and higher infant diet diversity.ConclusionsThe novel finding that both maternal diet index during pregnancy and infant diet diversity at 12 months are associated with the risk of a combined allergic disease outcome points to two targets for preventive interventions: maternal diet index scores during pregnancy and offspring diet diversity during infancy.

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Maternal Omega-3 Supplementation During Pregnancy, but Not Childhood Supplementation, Reduces the Risk of Food Allergy Diseases in Offspring

Cited by 3 publications

References 41 publications

Update on In Vitro Diagnostic Tools and Treatments for Food Allergies

Update on In Vitro Diagnostic Tools and Treatments for Food Allergies

Modulation of the Immune Response to Allergies Using Alternative Functional Foods

Maternal allergy‐preventive diet index, offspring infant diet diversity, and childhood allergic diseases

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