Maternal omega-3 fatty acid supplementation protects against lipopolysaccharide-induced white matter injury in the neonatal rat brain

Tüzün, Funda; Kumral, Abdullah; Dilek, Mustafa; Özbal, Seda; Ergur, Bekir Uğur; Yesilirmak, Didem Cemile; Duman, Nuray; Yılmaz, Osman; Özkan, Hasan

doi:10.3109/14767058.2011.587917

Cited by 35 publications

(17 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, a PUFA-enriched diet prevents post-injury loss of myelin, preserving the integrity of the myelin sheath, and maintaining the nerve fiber conductivity (85). In a different paradigm, maternal omega-3 fatty acid supplementation protects the neonatal rat brain from white matter injury due to lipopolysaccharide exposure (86). …”

Section: Discussionmentioning

confidence: 99%

Omega-3 polyunsaturated fatty acid supplementation and white matter changes in major depression

Chhetry

Hezghia

Miller

et al. 2016

Journal of Psychiatric Research

View full text Add to dashboard Cite

White matter abnormalities are implicated in major depressive disorder (MDD). As omega-3 polyunsaturated fatty acids (PUFAs) are low in MDD and affect myelination, we hypothesized that PUFA supplementation may alleviate depression through improving white matter integrity. Acutely depressed MDD patients (n=16) and healthy volunteers (HV, n=12) had 25-direction diffusion tensor imaging before and after 6 weeks of fish oil supplementation. Plasma phospholipid omega-3 PUFAs eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and omega-6 PUFA arachidonic acid (AA) levels were determined before and after supplementation using high-throughput extraction and gas chromatography and expressed as a percentage of total phospholipids (PUFA%). Fractional anisotropy (FA) was computed using a least-squares-fit diffusion tensor with non-linear optimization. Regression analyses were performed with changes in PUFA levels or Hamilton Depression Rating Scale scores as predictors, voxel-wise difference maps of FA as outcome, covariates age and sex, with family-wise correction for multiple comparisons. Increases in plasma phospholipid DHA% (but not EPA% or AA%) after fish oil predicted increases in FA in MDD but not HV, in a cluster including genu and body of the corpus callosum, and anterior corona radiata and cingulum (cluster-level p<0.001, peak t-score=8.10, p=0.002). There was a trend for greater change in FA in MDD responders over nonresponders (t=−1.874, df=13.56, p=0.08). Decreased depression severity predicted increased FA in left corticospinal tract and superior longitudinal fasciculus (cluster-level p<0.001, peak t-score=5.04, p=0.0001). Increased FA correlated with increased DHA% and decreased depression severity after fish oil supplementation suggests therapeutic effects of omega-3 PUFAs may be related to improvements in white matter integrity.

show abstract

Section: Discussionmentioning

confidence: 99%

Omega-3 polyunsaturated fatty acid supplementation and white matter changes in major depression

Chhetry

Hezghia

Miller

et al. 2016

Journal of Psychiatric Research

View full text Add to dashboard Cite

show abstract

“…Meta-analyses indicate that schizophrenia [27], bipolar disorder [28], and unipolar depression [29] are associated with PUFA deficits including DHA. Preclinical studies further suggest that n-3 PUFAs promote oligodendrocyte maturation and myelin expression [30,31], and are protective against axonal WM injury induced by trauma [32] and inflammation [33,34]. However, other studies suggest that maternal n-3 PUFA supplementation or deficiency impair neonatal axonal conduction, which is consistent with dysmyelination [35][36][37].…”

mentioning

confidence: 82%

Deficits in Docosahexaenoic Acid Accrual during Adolescence Reduce Rat Forebrain White Matter Microstructural Integrity: An in vivo Diffusion Tensor Imaging Study

et al. 2017

View full text Add to dashboard Cite

Neuropsychiatric disorders that frequently initially emerge during adolescence are associated with deficits in the omega-3 (n-3) fatty acid docosahexaenoic acid (DHA), elevated proinflammatory signaling, and regional reductions in white matter integrity (WMI). This study determined the effects of altering brain DHA accrual during adolescence on WMI in the rat brain by diffusion tensor imaging (DTI), and investigated the potential mediating role of proinflammatory signaling. During periadolescent development, male rats were fed a diet deficient in n-3 fatty acids (DEF, n = 20), a fish oil-fortified diet containing preformed DHA (FO, n = 20), or a control diet (CON, n = 20). In adulthood, DTI scans were performed and brain WMI was determined using voxelwise tract-based spatial statistics (TBSS). Postmortem fatty acid composition, peripheral (plasma IL-1β, IL-6, and C-reactive protein [CRP]) and central (IL-1β and CD11b mRNA) proinflammatory markers, and myelin basic protein (MBP) mRNA expression were determined. Compared with CON rats, forebrain DHA levels were lower in DEF rats and higher in FO rats. Compared with CON rats, DEF rats exhibited greater radial diffusivity (RD) and mean diffusivity in the right external capsule, and greater axial diffusivity in the corpus callosum genu and left external capsule. DEF rats also exhibited greater RD than FO rats in the right external capsule. Forebrain MBP expression did not differ between groups. Compared with CON rats, central (IL-1β and CD11b) and peripheral (IL-1β and IL-6) proinflammatory markers were not different in DEF rats, and DEF rats exhibited lower CRP levels. These findings demonstrate that deficits in adolescent DHA accrual negatively impact forebrain WMI, independently of elevated proinflammatory signaling.

show abstract

“…Diet in particular has been studied in the context of developmental myelination, where polyunsaturated fatty acids (PUFAs) have been linked to increased myelin gene expression and protection against white matter injury, with PUFA administration during maternal gestation leading to accelerated myelination and early development of behavioral reflexes (Confaloni et al, 1993;Gozzo et al, 1982;Salvati et al, 1996;Salvati et al, 2002;Tian et al, 2011;Tuzun et al, 2012). PUFAs are integral components of cell membranes including myelin membranes (Yurlova et al, 2011).…”

Section: Common Effectors? the Potential For Intersecting Mechanisms mentioning

confidence: 99%

Behavioral experiences as drivers of oligodendrocyte lineage dynamics and myelin plasticity

2016

View full text Add to dashboard Cite

Many behavioral experiences are known to promote hippocampal neurogenesis. In contrast, the ability of behavioral experiences to influence the production of oligodendrocytes and myelin sheath formation remains relatively unknown. However, several recent studies indicate that voluntary exercise and environmental enrichment can positively influence both oligodendrogenesis and myelination, and that, in contrast, social isolation can negatively influence myelination. In this review we summarize studies addressing the influence of behavioral experiences on oligodendrocyte lineage cells and myelin, and highlight potential mechanisms including experience-dependent neuronal activity, metabolites, and stress effectors, as well as both local and systemic secreted factors. Although more study is required to better understand the underlying mechanisms by which behavioral experiences regulate oligodendrocyte lineage cells, this exciting and newly emerging field has already revealed that oligodendrocytes and their progenitors are highly responsive to behavioral experiences and suggest the existence of a complex network of reciprocal interactions among oligodendrocyte lineage development, behavioral experiences, and brain function. Achieving a better understanding of these relationships may have profound implications for human health, and in particular, for our understanding of changes in brain function that occur in response to experiences. This article is part of the Special Issue entitled 'Oligodendrocytes in Health and Disease'.

show abstract

Maternal omega-3 fatty acid supplementation protects against lipopolysaccharide-induced white matter injury in the neonatal rat brain

Abstract: Considering that no specific treatment is available for PVL, maternal ω3 FA supplementation may provide a nutritional strategy to limit periventricular white matter damage caused by infections during pregnancy.

Cited by 35 publications

References 42 publications

Omega-3 polyunsaturated fatty acid supplementation and white matter changes in major depression

Omega-3 polyunsaturated fatty acid supplementation and white matter changes in major depression

Deficits in Docosahexaenoic Acid Accrual during Adolescence Reduce Rat Forebrain White Matter Microstructural Integrity: An in vivo Diffusion Tensor Imaging Study

Behavioral experiences as drivers of oligodendrocyte lineage dynamics and myelin plasticity

Contact Info

Product

Resources

About