Maternal occupational exposure to carbonaceous nanoscale particles and small for gestational age and the evolution of head circumference in the French Longitudinal Study of Children - Elfe study

Manangama, Guyguy; Audignon-Durand, Sabyne; Migault, Lucile; Gramond, Céline; Zaros, Cécile; Teysseire, Raphaëlle; Sentilhes, Loïc; Brochard, Patrick; Lacourt, Aude; Delva, Fleur

doi:10.1016/j.envres.2020.109394

Cited by 10 publications

(3 citation statements)

References 55 publications

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“…Moreover, the small size of the exposed group did not allow us to refine the analysis with other data, such as the length and period of the occupational exposure to UFPs (e.g., during the first, second or third trimester of pregnancy). Some studies suggest greater adverse effects on fetal growth and low birth weight after an exposure of the mother during the second and third trimester of the pregnancy, either to particulate matter [ 35 , 36 ] or to carbonaceous particles [ 37 , 38 ]. These results might be explained by a saturation of the placental mechanisms of compensation after a certain length of exposure to UFPs.…”

Section: Discussionmentioning

confidence: 99%

Occupational Exposure to Ultrafine Particles and Placental Histopathological Lesions: A Retrospective Study about 130 Cases

Pasquiou

Pelluard

Manangama

et al. 2021

IJERPH

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Ultrafine particles (UFPs) are particles smaller than 100 nanometers that are produced unintentionally during human activities or natural phenomena. They have a higher biological reactivity than bigger particles and can reach the placenta after maternal exposure. One study has shown an association between maternal occupational exposure to UFPs and fetal growth restriction. Yet few studies have focused on the effects of UFP exposure on placental histopathological lesions. The aim of this study was to investigate the association between maternal occupational exposure to UFPs and histopathological lesions of their placenta. The analyses were based on data from the ARTEMIS Center. A job-exposure matrix was used to assess occupational exposure to UFPs. The histopathological placental exam was performed by two pathologists who were blinded to the exposure of each subject. The examination was conducted in accordance with the recommendations of the Amsterdam consensus. The study sample included 130 placentas (30 exposed, 100 unexposed). Maternal occupational exposure to UFPs during pregnancy is significantly associated with placental hypoplasia (the phenomenon affected 61% of the exposed patients and 34% of the unexposed ones, p < 0.01). Further research is needed to explain its pathophysiological mechanisms.

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Section: Discussionmentioning

confidence: 99%

Occupational Exposure to Ultrafine Particles and Placental Histopathological Lesions: A Retrospective Study about 130 Cases

Pasquiou

Pelluard

Manangama

et al. 2021

IJERPH

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“…[25]. The main sources of ultrafine particles include combustion and exposure to ultrafine carbon particles (mainly from combustion) in the workplace and have been shown to be associated with a risk of low birth weight [29]. Animal studies have shown that ultrafine particles can act by a direct mechanism of toxicity on the placenta, as well as by indirect mechanisms through oxidative stress and inflammation [30].…”

Section: Explanation Of Findingsmentioning

confidence: 99%

Greater Risk of Pregnancy Complications for Female Surgeons: A Cross-Sectional Electronic Survey

Delva

Carcasset²,

Mouton

et al. 2022

IJERPH

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Background: Female surgeons are exposed to physical and mental stressors that differ from those of other specialties. We aimed to assess whether female surgeons are more at risk of pregnancy complications than women in other medical specialties. Methods: We used a cross-sectional electronic survey of female physicians working in the French Region Nouvelle-Aquitaine who were pregnant between 2013 and 2018. A pregnancy complication was defined as the occurrence of miscarriage, ectopic pregnancy, fetal growth restriction, prematurity, fetal congenital malformation, stillbirth, or medical termination of the pregnancy. Multivariate logistic regression models were used to evaluate the risk of pregnancy complications for female surgeons relative to women practicing in other medical specialties. Results: Among the 270 women included, 52 (19.3%) experienced pregnancy complications and 28 (10.4%) were surgeons. In the multivariate analysis, female surgeons had a higher risk of pregnancy complications: adjusted odds ratio = 3.53, 95% confidence interval [1.27–9.84]. Conclusion: Further research is necessary to identify the hazards specifically involved in the practice of surgery to be able to propose preventive actions targeted to female surgeons during their pregnancy.

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“…For example, placental vascular restriction leads to low birth weight (BW) but normal brain growth, and thus normal head circumference (HC) at birth, because distribution of the fetal vascular blood flow to the brain increases 4. Viral infection or pollutant exposure may specifically impair brain growth while the rest of the body develops normally, thus resulting in isolated microcephaly 5 6. Therefore, the head-to-body concordance, or more precisely, the relative concordance of BW and HC might be a better proxy than BW alone for defining the quality of fetal growth and assessing the effects of morbidity during pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Birth weight and head circumference discordance and outcome in preterms: results from the EPIPAGE-2 cohort

Guellec,

Brunet,

Lapillonne

et al. 2024

Arch Dis Child

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ObjectiveTo determine whether the relative measurement of birth weight (BW) and head circumference (HC) in preterm infants is associated with neurological outcomes.MethodsThe EPIPAGE-2 Study included 3473 infants born before 32 weeks’ gestation, classified based on their Z-score of BW and HC on the Fenton curves as concordant (≤1 SD apart) or discordant (>1 SD difference). We defined four mutually exclusive categories: discordant smaller BW (sBW) with BW<HC, discordant smaller HC (sHC) with HC<BW, concordant measurement (CM) with BW and HC concordant and both >−1SD and concordant small measurement (CsM) with BW and HC concordant and both ≤−1SD. Neurological outcomes at 5.5 years were evaluated with standard tests.Results2592 (74.8%) preterm neonates were categorised as CM, 258 (7.4%) CsM, 378 (10.9%) sHC and 239 (6.9%) sBW. Compared with the CM children, those born with CsM had significantly higher risks of cognitive deficiency (adjusted OR (aOR) 1.3, 95% CI (1.0 to 2.0)), developmental coordination disorders (aOR 2.6 (1.5 to 4.4)) and need for special school services (aOR 2.3 (1.5 to 3.7)). Those born with sBW had significantly lower risk of cognitive deficiency (aOR 0.6 (0.4 to 0.9)) and the sHC group significantly higher risk of developmental coordination disorders (aOR 1.8 (1.0 to 3.2)).ConclusionsThe relative discordance of these preterm infants’ BW and HC was associated with their neurological outcomes. It merits further exploration as an indirect indicator of development.Trial registration numberNCT03078439.

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Maternal occupational exposure to carbonaceous nanoscale particles and small for gestational age and the evolution of head circumference in the French Longitudinal Study of Children - Elfe study

Cited by 10 publications

References 55 publications

Occupational Exposure to Ultrafine Particles and Placental Histopathological Lesions: A Retrospective Study about 130 Cases

Occupational Exposure to Ultrafine Particles and Placental Histopathological Lesions: A Retrospective Study about 130 Cases

Greater Risk of Pregnancy Complications for Female Surgeons: A Cross-Sectional Electronic Survey

Birth weight and head circumference discordance and outcome in preterms: results from the EPIPAGE-2 cohort

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