Maternal obesity is a risk factor for orofacial clefts: a meta-analysis

Non-Syndromic Oral Clefts: A Glimpse on Environmental Risk Factors- A Mini-Review

“…Despite the existing controversies regarding the relationship between maternal pre-pregnancy weight and development of oral clefts, it has been lately confirmed that obese women are at higher risk to deliver children with CL/P [14]. Moreover, it was suggested that both overweight and underweight interfere with the process of palatal development [15].…”

Population Attributable Fractions of Modifiable Risk Factors for Nonsyndromic Orofacial Clefts: A Prospective Cohort Study From the Japan Environment and Children’s Study

“…[6][7][8][9] Besides, maternal obesity is also associated with approximately 1.2 times risk. [10][11][12] A review suggested the associations between stressful event and CL±P. 9 Although maternal alcohol consumption during the pregnancy is recognized as a potential risk factor for orofacial clefts, there is no consistent evidence.…”

Role of epigenetics and miRNAs in orofacial clefts

“…Some of the known risk factors for OFCs include polymorphisms of genes that influence orofacial development, parental lifestyle and related health conditions (i.e., smoking, obesity, and diabetes) (Åberg, Westbom, & Källén, 2001; Blanco, Colombo, & Suazo, 2015; Health & Services, 2014), pharmaceuticals and nutritional supplements (G. Shaw, 1995; G. M. Shaw, Wasserman, O'Malley, Tolarova, & Lammer, 1995), and environmental exposure to chemicals (Spinder et al, 2017). It is suspected that many OFC cases result from a combination of these factors.…”