Maternal Obesity and Risk of Infant Death Based on Florida Birth Records for 2004

Thompson, Denisse R.; Clark, Cheryl L.; Wood, Betsy; Zeni, Mary Beth

doi:10.1177/003335490812300410

Cited by 22 publications

(20 citation statements)

References 27 publications

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“…Twelve studies adjusted for potential confounders and 8 adjusted for deprivation or a suitable proxy, but only 5 provided adjusted data suitable for extraction and use in the main metaanalysis (all of which adjusted for by guest on May 12, 2018 http://pediatrics.aappublications.org/ Downloaded from deprivation), although another 3 adjusted using hazard ratios (also adjusted for deprivation) and were subject to a separate, adjusted data metaanalysis. 11,14,15,25,26,[28][29][30]33,39,41,42 Measure of Effect Meta-analysis was performed for obese mothers (BMI $30), mothers with a greater level of obesity (BMI $35), and all overweight or obese mothers (BMI $25). Although 19 studies had extractable data suitable for inclusion in the meta-analysis, only 11 used a consistent BMI definition for the referent group or for obesity; therefore, only these were included in the primary analysis comparing obese and nonobese mothers and the odds of them experiencing an infant death.…”

Section: Risk Of Bias Within Studiesmentioning

confidence: 99%

“…Both of these showed similar pooled effect measures to the primary analysis and are also summarized in Table 1. 11,14,25,26,30 Results of Individual Studies and Synthesis of Results: Narrative Analyses A narrative analysis was undertaken for 5 studies where it was not possible to include their data in the meta-analysis. Two studies were from the United Kingdom, 2 from the United States, and 1 from Jamaica.…”

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confidence: 99%

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Maternal Obesity and Infant Mortality: A Meta-Analysis

et al. 2014

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BACKGROUND AND OBJECTIVES: Despite numerous studies reporting an elevated risk of infant mortality among women who are obese, the magnitude of the association is unclear. A systematic review and metaanalysis was undertaken to assess the association between maternal overweight or obesity and infant mortality.METHODS: Four health care databases and gray literature sources were searched and screened against the protocol eligibility criteria. Observational studies reporting on the relationship between maternal overweight and obesity and infant mortality were included. Data extraction and risk of bias assessments were performed.RESULTS: Twenty-four records were included from 783 screened. Obese mothers (BMI $30) had greater odds of having an infant death (odds ratio 1.42; 95% confidence interval, 1.24-1.63; P , .001; 11 studies); these odds were greatest for the most obese (BMI .35) (odds ratio 2.03; 95% confidence interval, 1.61-2.56; P , .001; 3 studies). CONCLUSIONS:Our results suggest that the odds of having an infant death are greater for obese mothers and that this risk may increase with greater maternal BMI or weight; however, residual confounding may explain these findings. Given the rising prevalence of maternal obesity, additional high-quality epidemiologic studies to elucidate the actual influence of elevated maternal mass or weight on infant mortality are needed. If a causal link is determined and the biological basis explained, public health strategies to address the issue of maternal obesity will be needed. Mr Meehan developed the protocol, executed the search strategy, screened all records, assessed risk of bias, extracted data, carried out the data analysis, interpreted results, and prepared the manuscript draft; Dr Beck advised on study methods and analysis, extracted data, assessed methodological quality, and reviewed and revised the manuscript; Mr Mair-Jenkins extracted data, assessed methodological quality, and reviewed and revised the manuscript; Dr Leonardi-Bee advised on study methods and analysis, provided arbitration, critically appraised the analysis, and reviewed and revised the manuscript; Dr Puleston supervised the study, screened all records for eligibility, extracted data and prepared, and reviewed and revised the manuscript; and all authors approved the manuscript for submission.The protocol is registered at the National Institute for Health Research international prospective register of systematic reviews (identifier CRD42012002171). Overweight and obesity are increasing in women of childbearing age and during pregnancy. 2 The prevalence of maternal obesity ranges from 1.8% to 25.3% across different countries. 3 A recent study from the United States showed an increase in the prevalence of obesity during pregnancy from 13.0% in 1993 to 22.0% in 2003. 4 Obese pregnant women are likely to be older, have higher parity, and live in areas of higher deprivation than nonobese women. 3 Although global infant mortality rates have declined from 61 to 40 deaths per 1000 live births betw...

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Section: Risk Of Bias Within Studiesmentioning

confidence: 99%

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confidence: 99%

Maternal Obesity and Infant Mortality: A Meta-Analysis

et al. 2014

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“…While it is generally accepted that obesity is associated with adverse health outcomes, studies have also shown that maternal obesity is specifically associated with a variety of pregnancy complications, including labor and delivery difficulties, fetal and neonatal death, maternal hypertension, preeclampsia, and gestational diabetes (Lu et al, 2001), (Bhattacharya et al, 2007), (Thompson et al, 2008). Furthermore, it is possible that maternal obesity might precipitate adverse outcomes that persist through adulthood in offspring.…”

Section: Introductionmentioning

confidence: 99%

Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: Contributions of maternal diet

White

Pistell

Purpera

et al. 2009

Neurobiology of Disease

211

163

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This study was undertaken to investigate the effects of prenatal and postnatal exposure to high fat diet on the brain. Female rats were divided into high fat diet (HFD) and control diet (CD) groups 4 weeks prior to breeding and throughout gestation and lactation. After weaning, male progeny were placed on a chow diet until 8 weeks old, and then segregated into HFD or CD groups. At 20 weeks old, rats were evaluated in the Morris water maze, and markers of oxidative stress and inflammation were documented in brain. In comparison to rats fed CD, cognitive decline in HFD progeny from HFD dams manifested as a decline in retention, but not acquisition, in the water maze. HFD was also associated with significant increases in 3-nitrotyrosine, inducible nitric oxide synthase, IL-6, and glial markers Iba-1 and GFAP, with the largest increases frequently observed in HFD animals born to HFD dams. Thus, these data collectively suggest that HFD increases oxidative and inflammatory signaling in brain, and further indicate that maternal HFD consumption might sensitize offspring to the detrimental effects of HFD.

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“…It is important to know this because a form of selection bias could be introduced if cases with missing BMI have different characteristics from controls. Stott-Miller et al [46] included only live birth of women, and it is known that obese women are at risk of fetal death [66]. Therefore, they may have differentially underestimated the true odds of birth defect amongst obese women and thus underestimated the risk.…”

Section: Discussionmentioning

confidence: 99%

What is the Risk of Having Offspring with Cleft Lip/Palate in Pre-Maternal Obese/Overweight Women When Compared to Pre-Maternal Normal Weight Women? A Systematic Review and Meta-Analysis

Izedonmwen¹,

Cunningham²,

Macfarlane

2015

JOMR

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Objectives: The purpose of the study was to identify the risk of orofacial cleft in the offspring of women with pre-maternal obesity/overweight when compared with pre-maternal normal weight women. Material and Methods: MEDLINE and EMBASE were searched from 1980 to July 2014 for cohort, case control and cross sectional studies. BMI were categorized according to WHO recommendation: normal weight (BMI 18.5 -24.9), overweight (BMI 25 -29.9) and obese (BMI ≥ 30). Results: Six studies were identified; three case control studies which were used for the meta-analysis and two cross sectional studies and one cohort study. Compared with women of recommended BMI, obese women were at increased odds of pregnancy affected by CLP (OR = 1.16; 95% CI 1, 1.34) and CP (OR = 1.14; 95% CI 0.95, 1.37). Overweight women were also at increased odds of pregnancy affected by CLP (OR = 1.06; 95% CI 0.93, 1.21) but not CP (OR = 0.89; 95% CI 0.75, 1.06). The results of the risk ratios reported in the cross sectional and cohort studies were similar to the results of the meta-analysis. Conclusions:The results of this study reveal that there is an increased risk of having offspring with orofacial cleft in obese/ overweight women. The reason for this association is not known. Although, the risk is small, it is important because of the increasing incidence of obesity.

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Maternal Obesity and Risk of Infant Death Based on Florida Birth Records for 2004

Cited by 22 publications

References 27 publications

Maternal Obesity and Infant Mortality: A Meta-Analysis

Maternal Obesity and Infant Mortality: A Meta-Analysis

Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: Contributions of maternal diet

What is the Risk of Having Offspring with Cleft Lip/Palate in Pre-Maternal Obese/Overweight Women When Compared to Pre-Maternal Normal Weight Women? A Systematic Review and Meta-Analysis

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