Maternal obesity and dyslipidemia associated with gestational diabetes mellitus (GDM)

O’Malley, Eimer G.; Reynolds, Ciara; Killalea, Anne; O’Kelly, Ruth; Sheehan, Sharon R.; Turner, Michael J.

doi:10.1016/j.ejogrb.2020.01.007

Cited by 39 publications

(34 citation statements)

References 23 publications

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“…The only significant increase was observed in the triglycerides values, confirming the results already shown in literature [32,33]. Despite the stability of the standard glycemic parameters, this increase could reflect an obesogenic pathway [34] due to an inflammatory and metabolic effect on insulin resistance of PAF, TNF-alfa [35], MGO [36], and GA [37], that needs further investigation. (2) Maternal body weight increased after 12 weeks, while fat mass reduced.…”

Section: Discussionsupporting

confidence: 83%

Methylglyoxal, Glycated Albumin, PAF, and TNF-α: Possible Inflammatory and Metabolic Biomarkers for Management of Gestational Diabetes

Piuri¹,

Basello

Rossi

et al. 2020

Nutrients

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Background: In gestational diabetes mellitus (GDM), pancreatic β-cell breakdown can result from a proinflammatory imbalance created by a sustained level of cytokines. In this study, we investigated the role of specific cytokines, such as B-cell activating factor (BAFF), tumor necrosis factor α (TNF-α), and platelet-activating factor (PAF), together with methylglyoxal (MGO) and glycated albumin (GA) in pregnant women affected by GDM. Methods: We enrolled 30 women whose inflammation and metabolic markers were measured at recruitment and after 12 weeks of strict dietetic therapy. We compared these data to the data obtained from 53 randomly selected healthy nonpregnant subjects without diabetes, hyperglycemia, or any condition that can affect glycemic metabolism. Results: In pregnant women affected by GDM, PAF levels increased from 26.3 (17.4–47.5) ng/mL to 40.1 (30.5–80.5) ng/mL (p < 0.001). Their TNF-α levels increased from 3.0 (2.8–3.5) pg/mL to 3.4 (3.1–5.8) pg/mL (p < 0.001). The levels of methylglyoxal were significantly higher in the women with GDM (p < 0.001), both at diagnosis and after 12 weeks (0.64 (0.46–0.90) μg/mL; 0.71 (0.47–0.93) μg/mL, respectively) compared to general population (0.25 (0.19–0.28) μg/mL). Levels of glycated albumin were significantly higher in women with GDM (p < 0.001) only after 12 weeks from diagnosis (1.51 (0.88–2.03) nmol/mL) compared to general population (0.95 (0.63–1.4) nmol/mL). Conclusion: These findings support the involvement of new inflammatory and metabolic biomarkers in the mechanisms related to GDM complications and prompt deeper exploration into the vicious cycle connecting inflammation, oxidative stress, and metabolic results.

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Section: Discussionsupporting

confidence: 83%

Methylglyoxal, Glycated Albumin, PAF, and TNF-α: Possible Inflammatory and Metabolic Biomarkers for Management of Gestational Diabetes

Piuri¹,

Basello

Rossi

et al. 2020

Nutrients

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“…Physical activity protocols could improve the nursing and midwifery consultations as a support measure for pregnant patients. These protocols can prevent different problems associated with a sedentary lifestyle in pregnant women, e.g., excessive weight gain during pregnancy [14], GDM [7], high blood pressure, respiratory distress syndrome, and hypocalcaemia [21][22][23][24]. These protocols can also prevent fetus-related complications, e.g., macrosomia, impaired intrauterine growth, obstetric trauma, hyperbilirubinemia, hypoglycemia, intection, and length of stay in the intensive care unit [12].…”

Section: Implications For Clinical Practicementioning

confidence: 99%

“…There is also the possibility that the child will suffer complications as macrosomia, impaired intrauterine growth, obstetric trauma, hyperbilirubinemia, hypoglycemia, intection, and a length of stay in the intensive care unit [12]. A combination of diet and exercise reduces excessive weight gain during pregnancy and GDM because weight gain is directly related to GDM development [13,14]. In addition, obese women tend to have an unbalanced glucose tolerance and higher insulin resistance during pregnancy than those with a healthy weight [7].…”

Section: Introductionmentioning

confidence: 99%

Physical Activity Programs during Pregnancy Are Effective for the Control of Gestational Diabetes Mellitus

Laredo-Aguilera

Gallardo-Bravo

Rabanales-Sotos

et al. 2020

IJERPH

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Gestational diabetes mellitus has an incidence of 14% worldwide and nursing is responsible for its monitoring during pregnancy. Excessive weight gain during pregnancy is directly related to gestational diabetes mellitus development. Gestational diabetes mellitus (GDM) has negative repercussions on the evolution of the pregnancy and the fetus. The objective of this systematic review is to establish how physical activity influences pregnant women with gestational diabetes mellitus and to analyze what benefits physical activity has in the control of gestational diabetes mellitus. A systematic search was carried out in different databases (Cochrane, Superior Council of Scientific Investigations (CSIC), EBSCOhost, Pubmed, Scopus, Web os Science, and Proquest) for papers published within the last 12 years, taking into account different inclusion and exclusion criteria. Six randomized controlled studies and one observational case-control study of a high quality were selected. Fasting, postprandial glucose and HbcA1 were assessed, as well as the requirement and amount of insulin used. Thus, there is a positive relationship between the performance of physical activity and the control of gestational diabetes mellitus. Resistance, aerobic exercise, or a combination of both are effective for the control of glucose, HbcA1, and insulin. Due to the variability of the exercises of the analyzed studies and the variability of the shape of the different pregnant women, it does not permit the recommendation of a particular type of exercise. However, any type of physical activity of sufficient intensity and duration can have benefits for pregnant women with GDM. Pregnant women with gestational diabetes mellitus should exercise for at least 20–50 min a minimum of 2 times a week with at a least moderate intensity.

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“…However, the etiology of GDM has not been clear yet so far, and the pathogenesis needs further study. At present, it is generally believed that maternal obesity and lipid metabolism disorder are related to the occurrence of GDM [ 4 , 5 ]. Nowadays, many specialists focus their eyes on the role of adipokines, which contributes to the metabolic abnormalities in the mother.…”

Section: Introductionmentioning

confidence: 99%

Changes of Serum Zinc-α2-Glycoprotein Level and Analysis of Its Related Factors in Gestational Diabetes Mellitus

You

Chen

et al. 2021

Journal of Diabetes Research

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Previous studies have discovered that zinc-α2-glycoprotein (ZAG) is related to insulin resistance and lipid metabolism. The aim of the study is to explore the change of serum ZAG and its related factors in gestational diabetes mellitus (GDM). Eighty newly diagnosed GDM patients were enrolled in the case group, and 80 normal pregnant women were selected as the control group. The differences of baseline data between the two groups were compared, and the change of serum ZAG level and its relationship with related indexes was analyzed. Compared to the control group, the level of serum ZAG in GDM women decreased ( P < 0.001 ). What is more, the serum ZAG level of overweight and normal subjects in two groups was also found to have statistical differences. The Pearson correlation (or Spearman correlation) analysis showed that serum ZAG level was negatively correlated with FPG, FINS, HOMA-IR, and TG (all P < 0.05 ) and positively correlated with HDL ( P < 0.05 ). Multiple linear regression showed that HDL and HOMA-IR were independent factors of serum ZAG ( P < 0.05 ). The level of serum ZAG in patients with gestational diabetes mellitus decreased, and HDL and HOMA-IR are the influencing factors in the case group.

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Maternal obesity and dyslipidemia associated with gestational diabetes mellitus (GDM)

Cited by 39 publications

References 23 publications

Methylglyoxal, Glycated Albumin, PAF, and TNF-α: Possible Inflammatory and Metabolic Biomarkers for Management of Gestational Diabetes

Methylglyoxal, Glycated Albumin, PAF, and TNF-α: Possible Inflammatory and Metabolic Biomarkers for Management of Gestational Diabetes

Physical Activity Programs during Pregnancy Are Effective for the Control of Gestational Diabetes Mellitus

Changes of Serum Zinc-α2-Glycoprotein Level and Analysis of Its Related Factors in Gestational Diabetes Mellitus

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