Maternal nutrition during pregnancy and risk of asthma, wheeze, and atopic diseases during childhood: a systematic review and meta‐analysis

Beckhaus, Andrea A.; García‐Marcos, Luis; Forno, Erick; Pacheco-Gonzalez, Rosa; Celedón, Juan C.; Castro-Rodriguez, José A.

doi:10.1111/all.12729

Cited by 163 publications

(161 citation statements)

References 57 publications

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“…The authors postulated that the protective effects that were found only for wheeze may be through reduced susceptibility to viral infections. There was no association with asthma, eczema, or allergic rhinitis [19].…”

Section: Key Pointsmentioning

confidence: 81%

Breastfeeding and perinatal exposure, and the risk of asthma and allergies

Lodge

Dharmage

2016

Current Opinion in Allergy &Amp; Clinical Immunology

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A diverse range of exposures were associated with allergic disease risk, highlighting the susceptibility of children during the perinatal period. Clinicians should reinforce public health messages concerning maternal obesity, smoking, and breastfeeding. The infant gut microbiome is emerging as an important hypothesis, which may mediate the relationship between many perinatal exposures and allergic disease.

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Section: Key Pointsmentioning

confidence: 81%

Breastfeeding and perinatal exposure, and the risk of asthma and allergies

Lodge

Dharmage

2016

Current Opinion in Allergy &Amp; Clinical Immunology

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“…The levels of prenatal vitamin D on wheeze/asthma susceptibility in offspring have been extensively investigated in observational studies [49,50,91,92]. There are two meta-analyses that have shown high dietary vitamin D intake during pregnancy to be associated with a reduced risk of wheeze in the offspring (Nurmatov et al [91] OR 0.56, 95% CI 0.42-0.73; Beckhaus et al [92] OR 0.58, 95% CI 0.38-0.88).…”

Section: Prenatal Vitamin D Status and Asthma Riskmentioning

confidence: 99%

“…There are two meta-analyses that have shown high dietary vitamin D intake during pregnancy to be associated with a reduced risk of wheeze in the offspring (Nurmatov et al [91] OR 0.56, 95% CI 0.42-0.73; Beckhaus et al [92] OR 0.58, 95% CI 0.38-0.88). However, the results of metaanalysis from observational studies but based on maternal serum 25(OH)D concentrations on asthma/wheeze outcome are controversial yet.…”

Section: Prenatal Vitamin D Status and Asthma Riskmentioning

confidence: 99%

Maternal and Foetal Health Implications of Vitamin D Status during Pregnancy

Larqué

Morales

Leis³

et al. 2018

Ann Nutr Metab

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Background: To what extent does the circulating 25-hydroxyvitamin D (25[OH]D) concentration help to meet the physiological needs of humans is an ongoing subject of debate. Remaining unexposed to the sun to reduce melanoma cancer risk, current lifestyle with less out door activities, and increasing obesity rates, which in turn increases the storage of vitamin D in the adipose tissue, are presumably factors that contribute to the substantial upsurge in the prevalence of vitamin D deficiency in humans. Since evidence is lacking regarding the appropriate cut-off points to define vitamin D status during pregnancy, references used to establish the intake recommendations and vitamin D content of prenatal vitamin supplements are quite conservative. Summary: The foetus depends fully on maternal 25(OH)D supply. 25(OH)D readily crosses the placenta and it is activated into 1,25(OH)₂D by foetal kidneys. Moreover, 1,25(OH)₂D can also be synthesized within the placenta to regulate placental metabolism. The importance of vitamin D during pregnancy for maintaining maternal calcium homeostasis and therefore for foetal bone development is well recognized; major discussions are in progress regarding the potential maternal detrimental effects on pregnancy outcomes, foetal development, and the long-term health of children. Interventional studies have also evaluated the effect of vitamin D for reduction on preterm birth and asthma programming. Key Messages: Clinically, by understanding the effects of vitamin D on perinatal outcomes, we could individualize antenatal counselling regarding vitamin D supplementation to ensure vitamin D repletion without increasing the risk of foetal hypercalcemia.

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“…Regarding maternal diet during pregnancy, a small number of cohort studies have highlighted associations between wheezing in the first years of life and reduced maternal intake of vitamins E and D, zinc, and omega-3 PUFAs during pregnancy [11,21]. The few longitudinal studies conducted on associations between maternal dietary patterns during pregnancy and wheeze/asthma in the offspring reported, overall, no association [21].…”

Section: Diet and Asthma: Primary Preventionmentioning

confidence: 99%

“…The few longitudinal studies conducted on associations between maternal dietary patterns during pregnancy and wheeze/asthma in the offspring reported, overall, no association [21]. Regarding diet during childhood, few longitudinal studies have been published.…”

Section: Diet and Asthma: Primary Preventionmentioning

confidence: 99%