Maternal, neonatal and placental characteristics of SARS-CoV-2 positive mothers

Zhang, Peilin; Heyman, Taryn; Greechan, Marisa; Dygulska, Beata; Sayyed, Farah Al; Narula, Pramod; Lederman, Sanford

doi:10.1080/14767058.2021.1892637

Cited by 25 publications

(28 citation statements)

References 33 publications

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“…We identified a total of 1452 cases from 30 publications [ [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] ] ( Table 1 ). It should be taken into consideration that histological changes were not graded in all publications and even minor changes could have been summarized as “pathology”.…”

Section: Resultsmentioning

confidence: 99%

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Meta-analysis on COVID-19-pregnancy-related placental pathologies shows no specific pattern

et al. 2022

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Section: Resultsmentioning

confidence: 99%

“… 3 [ 35 ] 9 0 0 0 3 n.a. [ 36 ] 8 0 0 0 0 4 [ 37 ] 47 22 0 6 40 30 [ 38 ] 16 19 0 0 18 11 [ 39 ] 2 4 4 n.a. n.a.…”

Section: Resultsunclassified

Meta-analysis on COVID-19-pregnancy-related placental pathologies shows no specific pattern

et al. 2022

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“…These findings corroborate the results of recent studies of SARS-CoV-2-exposed infants that have found a low rate of symptomatology and positive testing after the perinatal period [ 5–7 ]. A recent article reported two infants born to SARS-CoV-2 positive mothers who tested positive for SARS-CoV-2 at seven days and one month of life [ 19 ]. Both infants were asymptomatic with normal development at follow-up clinic visits.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, as we did not conduct follow-up PCR testing on infants, we cannot say with certainty whether they acquired infection. However, we reasoned that other studies have already investigated rates of positive testing among exposed infants, and thus we purposefully selected clinically significant COVID-19 disease as our outcome of interest rather than positive SARS-CoV-2 testing in general [ 6 , 7 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

Short-term outcomes of infants born to mothers with SARS-CoV-2 infection

Moffat

Dessie

O’Leary

et al. 2021

The Journal of Maternal-Fetal & Neonatal Medicine

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Objective The rate of transmission of SARS-CoV-2 from mothers to infants in the peri- and post-natal period remains an area of ongoing investigation. This study aims to determine rates of development of clinically significant COVID-19 disease within 1 month among infants born to symptomatic and asymptomatic SARS-CoV-2 positive mothers. Materials and methods This was a single-center, retrospective cohort study of all infants born to SARS-CoV-2 positive mothers who were admitted to the Well Baby Nursery (WBN) at New York University Langone Hospital-Brooklyn from 23 March–23 September 2020. Infants born to asymptomatic mothers were allowed to room-in, while infants born to mothers with symptoms of SARS-CoV-2 were isolated and discharged home to an alternate primary caregiver. A phone follow-up program contacted mothers at 2 weeks and 1 month post discharge to inquire about newborn symptoms, maternal symptoms, personal protective equipment (PPE) usage, and any presentations to care. Medical records were also reviewed for clinic and hospital visits to determine if exposed infants developed any symptoms following discharge. Results Of 1903 deliveries during the study period, 131 mothers (21 symptomatic, 110 asymptomatic) tested positive for SARS-CoV-2 and had infants admitted to the WBN. 57 infants (21 born to symptomatic mothers, 36 born to asymptomatic mothers) were tested prior to discharge, and none were positive. 121 of 133 infants had at least 1 follow up call in the study period. Of these, 31 had symptoms potentially concerning for SARS-CoV-2 infection or Multisystem Inflammatory Syndrome in Children, and 19 presented to medical care for these symptoms. 4 infants had SARS- CoV-2 testing after discharge, and none were positive. 2 infants were admitted to the hospital for fever but neither had a positive SARS-CoV-2 result. 65% of mothers reported always adhering to PPE recommendations. Conclusion Our results suggest that infants born both to symptomatic and asymptomatic mothers are unlikely to develop clinically significant COVID-19 disease in the peri- and post-natal periods.

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“…In addition, the risk of vertical transmission after COVID-19 infection was reported as negligible. [20,22,23] In other studies, the risk of transmission from mother-toinfant was reported as 1.5-5%. On the other hand, the positivity rate was not higher in infants who stayed in the same room with the mother than infants initially separated and cared for in a SARS-CoV-2-free environment.…”

Section: Perinatal Journalmentioning

confidence: 91%

Comparison of the pregnancy outcomes of the patients with severe symptoms who received medical treatment for COVID-19 versus the patients with mild-moderate symptoms

Yüksel¹,

Tuna²,

Gencer³

et al. 2021

Perinatal J

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Objective COVID-19 has spread all over the world since December 2019. There is little evidence concerning maternal or perinatal outcomes up to now. The present study aimed to compare pregnant women with severe and mild-moderate COVID-19 symptoms in terms of maternal and perinatal outcomes. Methods The study group was composed of pregnant patients admitted to our tertiary center with symptoms and diagnosed with severe acute respiratory syndrome Coronavirus 2 (SARS-Cov-2). The patients were categorized into two groups: severe and not severe, and women determined as in the severe disease group were hospitalized. The patients were continued to their routine follow-up, their maternal and perinatal outcomes were recorded. Results A total of 52 patients were enrolled in the study: 59.6% presented mild-moderate disease and 40.4% presented severe disease. The gestational age at diagnosis of COVID-19 was higher in the patients with severe symptoms than in patients with mild-moderate symptoms (median 20.5 vs 28.0, respectively, p=0.048). There was no difference between those two groups in terms of maternal and perinatal outcomes. Conclusion Despite the growing number of published studies on COVID-19 in pregnancy, there are insufficient quality data to draw conclusions about the severity of COVID-19 in symptomatic pregnant women and its maternal and neonatal consequences. In our study, there is no difference between mild-moderate and severe groups in terms of maternal and perinatal outcomes.

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Maternal, neonatal and placental characteristics of SARS-CoV-2 positive mothers

Cited by 25 publications

References 33 publications

Meta-analysis on COVID-19-pregnancy-related placental pathologies shows no specific pattern

Meta-analysis on COVID-19-pregnancy-related placental pathologies shows no specific pattern

Short-term outcomes of infants born to mothers with SARS-CoV-2 infection

Comparison of the pregnancy outcomes of the patients with severe symptoms who received medical treatment for COVID-19 versus the patients with mild-moderate symptoms

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