Maternal neglect with reduced depressive-like behavior and blunted c-fos activation in Brattleboro mothers, the role of central vasopressin

Fodor, Anna; Klausz, Barbara; Pintér, Ottó; Daviu, Núria; Rabasa, Cristina; Rotllant, David; Balázsfi, Diána; Kovács, Katalin; Nadal, Roser; Zelena, Dóra

doi:10.1016/j.yhbeh.2012.09.003

Cited by 37 publications

(30 citation statements)

References 103 publications

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“…Similar lactation-dependent effects of AVP on impulsivity have not been reported previously, but our findings are consistent with studies showing that the behavioral effects of AVP deficiency (e.g. reduced depressive-like behavior) occur in a lactation-dependent manner in rats (Fodor et al, 2012).…”

Section: Discussionsupporting

confidence: 93%

“…Brattleboro rats develop a unique physiological and behavioral profile as a result of lacking a functioning AVP system. Among other things, these rats show normal baseline hypothalamus-pituitary-adrenal (HPA) axis activity and decreased HPA axis reactivity to a variety of stressors (Zelena et al, 2009), slightly reduced anxiety (Fodor et al, 2012) and depression-like behavior (Fodor et al, 2012;Mlynarik et al, 2007). Additionally, they display social deficits (Engelmann and Landgraf, 1994;Feifel et al, 2009;Schank, 2009) and impairments in cognitive performance (Aarde and Jentsch, 2006;Colombo et al, 1992;Varga et al, 2013).…”

Section: Introductionmentioning

confidence: 98%

“…in several cases on the specific physiological conditions during lactation. For example, AVP deficiency does not alter baseline HPA axis activity in virgin females, while it dampens chronic hyperactivity of the HPA axis in lactating female rats (Fodor et al, 2013), an effect that contributes to maternal neglect and mild anxiolysis (Fodor et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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The effects of lactation on impulsive behavior in vasopressin-deficient Brattleboro rats

Aliczki

Fodor

Balogh

et al. 2014

Hormones and Behavior

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Vasopressin (AVP)-deficient Brattleboro rats develop a specific behavioral profile, which-among other things-23 include altered cognitive performance. This profile is markedly affected by alterations in neuroendocrine state 24 of the animal such as during lactation. Given the links between AVP and cognition we hypothesized that AVP de-25 ficiency may lead to changes in impulsivity that is under cognitive control and the changes might be altered by 26 lactation. Comparing virgin and lactating AVP-deficient female Brattleboro rats to their respective controls, we 27 assessed the putative lactation-dependent effects of AVP deficiency on impulsivity in the delay discounting par-28 adigm. Furthermore, to investigate the basis of such effects, we assessed possible interactions of AVP deficiency 29 with GABAergic and serotonergic signaling and stress axis activity, systems playing important roles in impulse 30 control. Our results showed that impulsivity was unaltered by AVP deficiency in virgin rats. In contrast a 31 lactation-induced increase in impulsivity was abolished by AVP deficiency in lactating females. We also found 32 that chlordiazepoxide-induced facilitation of GABAergic and imipramine-induced enhancement of serotonergic 33 activity in virgins led to increased and decreased impulsivity, respectively. In contrast, during lactation these ef-34 fects were visible only in AVP-deficient rats. These rats also exhibited increased stress axis activity compared to 35 virgin animals, an effect that was abolished by AVP deficiency. Taken together, AVP appears to play a role in the 36 regulation of impulsivity exclusively during lactation: it has an impulsivity increasing effect which is potentially 37 mediated via stress axis-dependent mechanisms and fine-tuning of GABAergic and serotonergic function. Fodor et al., 2012; Mlynarik et al., 2007). Additionally, they display so-61 cial deficits (Engelmann and Landgraf, 1994; Feifel et al., 2009; Schank, 62 2009) and impairments in cognitive performance (Aarde and Jentsch, 63 2006; Colombo et al., 1992; Varga et al., 2013 71Prior work has shown that cognitive performance can be altered by 72 changes in impulsivity (Bizot and Thiebot, 1996). Impulsivity is general-

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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The effects of lactation on impulsive behavior in vasopressin-deficient Brattleboro rats

Aliczki

Fodor

Balogh

et al. 2014

Hormones and Behavior

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“…We recorded the biological mother's spontaneous maternal behaviour 3 times per day (8:15, 17:30 and 20:15) from PD1 to PD16 according to an adapted version of a previously described protocol (Dimitsantos et al, 2007;Fodor et al, 2012). The long break between the morning and afternoon maternal care evaluation session was consistent with the 8 h maternal separation period performed during .…”

Section: Maternal Carementioning

confidence: 99%

Maternal separation induces neuroinflammation and long-lasting emotional alterations in mice

Gracia-Rubio

Moscoso-Castro

Pozo

et al. 2016

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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112

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“…Radiograms were evaluated using the ImageJ program (http://rsbweb.nih.gov/ij/). The average grayness density of three sections on both hemispheres (Crh) or six sections (Pomc) taken at 80 mm intervals was used for analysis (Zelena et al 2007, Fodor et al 2012.…”

Section: In Situ Hybridizationmentioning

confidence: 99%

Blunted HPA axis response in lactating, vasopressin-deficient Brattleboro rats

Fodor¹,

Pintér²,

Domokos³

et al. 2013

Journal of Endocrinology

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Adaptation to stress is a basic phenomenon in mammalian life that is mandatorily associated with the activity of the hypothalamic-pituitary-adrenal (HPA) axis. An increased resting activity of the HPA axis can be measured during pregnancy and lactation, suggesting that these reproductive states lead to chronic load in females. In this study, we examined the consequences of the congenital lack of vasopressin on the activity of the HPA axis during lactation using vasopressindeficient Brattleboro rats. Virgin and lactating, homozygous vasopressin-deficient rats were compared with control, heterozygous rats. In control dams compared with virgins, physiological changes similar to those observed in a chronic stress state (thymus involution, adrenal gland hyperplasia, elevation of proopiomelanocortin mRNA levels in the adenohypophysis, and resting plasma corticosterone levels) were observed. In vasopressin-deficient dams, adrenal gland hyperplasia and resting corticosterone level elevations were not observed. Corticotropinreleasing hormone (Crh) mRNA levels in the hypothalamic paraventricular nucleus were elevated in only the control dams, while oxytocin (OT) mRNA levels were higher in vasopressin-deficient virgins and lactation induced a further increase in both the genotypes. Suckling-induced ACTH and corticosterone level elevations were blunted in vasopressin-deficient dams. Anaphylactoid reaction (i.v. egg white) and insulin-induced hypoglycemia stimulated the HPA axis, which were blunted in lactating rats compared with the virgins and in vasopressin-deficient rats compared with the controls without interaction of the two factors. Vasopressin seems to contribute to the physiological changes observed during lactation mimicking a chronic stress state, but its role in acute HPA axis regulation during lactation seems to be similar to that observed in virgins. If vasopressin is congenitally absent, OT, but not the CRH, compensates for the missing vasopressin; however, the functional restitution remains incomplete.

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Maternal neglect with reduced depressive-like behavior and blunted c-fos activation in Brattleboro mothers, the role of central vasopressin

Cited by 37 publications

References 103 publications

The effects of lactation on impulsive behavior in vasopressin-deficient Brattleboro rats

The effects of lactation on impulsive behavior in vasopressin-deficient Brattleboro rats

Maternal separation induces neuroinflammation and long-lasting emotional alterations in mice

Blunted HPA axis response in lactating, vasopressin-deficient Brattleboro rats

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