Maternal Metabolic and Endocrine Imbalances

The Association of Aplasia Cutis Congenita with Therapy of Maternal Thyroid Disease

“…Although no specific fetal structural abnormalities have been associated with hypothyroidism or hyperthyroidism, one may postulate that methimazole has an adverse affect on normal development of the skin and neural tube in the cranial region. [Persons with cretinism are well developed except for moderate retardation of secondary epiphyseal ossification, and the mental deficiency is reversed with postnatal thyroid hormone replacement (21). ]…”