Maternal low-protein diet during lactation programmes body composition and glucose homeostasis in the adult rat offspring

Fagundes, A. T. S.; Moura, Egberto Gaspar de; Passos, M. C. F.; Oliveira, Elaine de; Toste, Fabiane Pereira; Bonomo, I; Trevenzoli, Isis Hara; García, Raúl; Lisboa, Patrícia Cristina

doi:10.1017/s0007114507750924

Cited by 90 publications

(93 citation statements)

References 43 publications

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“…After weaning, even with an adequate supply of a commercial diet (23% protein) until 120 days of age, the programming of PR offspring resulted in a lower mean body weight, whereas CR programming resulted in overweight offspring. These findings corroborate our previous data using programmed rats (Passos et al 2000, 2004, Fagundes et al 2007, 2009. These alterations of body mass can be explained by hypophagia (PR mice) and hyperphagia (CR mice), which is a different conclusion than can be drawn from the rat model, in which food intake was unchanged.…”

Section: Discussionsupporting

confidence: 89%

“…The visceral fat mass (VFM) (mesenteric, epididymal and retroperitoneal adipose tissue) was excised and weighed for the evaluation of central adiposity. Fat mass was determined by carcass analysis as reported previously (Fagundes et al 2007). …”

Section: Methodsmentioning

confidence: 99%

“…Among children, protein-energy malnutrition is the most prevalent nutritional disorder and often occurs during gestation, lactation and the first two years of life (Desai et al 2000). In fact, experimental data have reported that maternal malnutrition during the critical period of lactation may have deleterious effects during the adult life of the offspring, even if the animal had free access to a normal diet after weaning (Passos et al 2000, 2004, Fagundes et al 2007, 2009.…”

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confidence: 99%

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The outcome of acute schistosomiasis infection in adult mice with postnatal exposure to maternal malnutrition

Corrêa

Lisboa

Oliveira

et al. 2011

Mem. Inst. Oswaldo Cruz

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Section: Discussionsupporting

confidence: 89%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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The outcome of acute schistosomiasis infection in adult mice with postnatal exposure to maternal malnutrition

Corrêa

Lisboa

Oliveira

et al. 2011

Mem. Inst. Oswaldo Cruz

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“…low protein, restricted energy intake) on pregnancy outcome in humans (Godfrey et al, 1996) and animals (Ozanne et al, 2004;Rees et al, 2006;Fagundes et al, 2007). High-protein (HP) diets have been shown to cause weight loss by inducing longer postprandial satiety and increase dietary thermogenesis that led to a lower subsequent energy intake (Johnston et al, 2002;Halton and Hu, 2004).…”

Section: Introductionmentioning

confidence: 99%

“…Reports on the impact of an increased dietary protein intake during gestation and lactation on maternal and foetal/offspring health and development are scarce and the results obtained are inconsistent (Daenzer et al, 2002;Zhang et al, 2005;Thone-Reineke et al, 2006). However, there seems to be a similarity with the effects of a low-protein diet that also causes decreased birth weight and altered body mass (BM) development of the offspring during lactation (Fagundes et al, 2007;Desai et al, 1996and 1997. Excess of nutrients can lead to altered milk volume (King et al, 1993;Del Prado et al, 1997), lactose (Pine et al, 1994) as well as milk fat concentrations (Aoki et al, 1999;Tilton et al, 1999) subsequent to changes in mammary gland (MG) structure and gene expression (Flint et al, 2005;Rudolph et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

High-protein diet during gestation and lactation affects mammary gland mRNA abundance, milk composition and pre-weaning litter growth in mice

Kucia

Langhammer

Görs

et al. 2011

Animal

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We evaluated the effect of a high-protein diet (HP) on pregnancy, lactational and rearing success in mice. At the time of mating, females were randomly assigned to isoenergetic diets with HP (40% w/w) or control protein levels (C; 20%). After parturition, half of the dams were fed the other diet throughout lactation resulting in four dietary groups: CC (C diet during gestation and lactation), CHP (C diet during gestation and HP diet during lactation), HPC (HP diet during gestation and C diet during lactation) and HPHP (HP diet during gestation and lactation). Maternal and offspring body mass was monitored. Measurements of maternal mammary gland (MG), kidney and abdominal fat pad masses, MG histology and MG mRNA abundance, as well as milk composition were taken at selected time points. HP diet decreased abdominal fat and increased kidney mass of lactating dams. Litter mass at birth was lower in HP than in C dams (14.8 v. 16.8 g). Dams fed an HP diet during lactation showed 5% less food intake (10.4 v. 10.9 g/day) and lower body and MG mass. On day 14 of lactation, the proportion of MG parenchyma was lower in dams fed an HP diet during gestation as compared to dams fed a C diet (64.8% v. 75.8%). Abundance of MG a-lactalbumin, b-casein, whey acidic protein, xanthine oxidoreductase mRNA at mid-lactation was decreased in all groups receiving an HP diet either during gestation and/or lactation. Milk lactose content was lower in dams fed an HP diet during lactation compared to dams fed a C diet (1.6% v. 2.0%). On days 14, 18 and 21 of lactation total litter mass was lower in litters of dams fed an HP diet during lactation, and the pups' relative kidney mass was greater than in litters suckled by dams receiving a C diet. These findings indicate that excess protein intake in reproducing mice has adverse effects on offspring early in their postnatal growth as a consequence of impaired lactational function.

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Baseline glucose level is an individual trait that is negatively associated with lifespan and increases due to adverse environmental conditions during development and adulthood

et al. 2018

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High baseline glucose levels are associated with pathologies and shorter lifespan in humans, but little is known about causes and consequences of individual variation in glucose levels in other species. We tested to what extent baseline blood glucose level is a repeatable trait in adult zebra finches, and whether glucose levels were associated with age, manipulated environmental conditions during development (rearing brood size) and adulthood (foraging cost), and lifespan. We found that: (1) repeatability of glucose levels was 30%, both within and between years. (2) Having been reared in a large brood and living with higher foraging costs as adult were independently associated with higher glucose levels. Furthermore, the finding that baseline glucose was low when ambient temperature was high, and foraging costs were low, indicates that glucose is regulated at a lower level when energy turnover is low. (3) Survival probability decreased with increasing baseline glucose. We conclude that baseline glucose is an individual trait negatively associated with survival, and increases due to adverse environmental conditions during development (rearing brood size) and adulthood (foraging cost). Blood glucose may be, therefore, part of the physiological processes linking environmental conditions to lifespan.

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Maternal low-protein diet during lactation programmes body composition and glucose homeostasis in the adult rat offspring

Cited by 90 publications

References 43 publications

The outcome of acute schistosomiasis infection in adult mice with postnatal exposure to maternal malnutrition

The outcome of acute schistosomiasis infection in adult mice with postnatal exposure to maternal malnutrition

High-protein diet during gestation and lactation affects mammary gland mRNA abundance, milk composition and pre-weaning litter growth in mice

Baseline glucose level is an individual trait that is negatively associated with lifespan and increases due to adverse environmental conditions during development and adulthood

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