Maternal longevity is associated with lower infant mortality

Caselli, Graziella; Lapucci, Enrica; Lipsi, Rosa Maria; Pozzi, Lucia; Baggio, Giovannella; Carru, Ciriaco; Deiana, Luca; Franceschi, Claudio; Vaupel, James W.

doi:10.4054/demres.2014.31.42

Cited by 7 publications

(5 citation statements)

References 36 publications

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“…These studies showed that: i) a non-random distribution of centenarians by place of birth and peculiar area (in the province of Nuoro) of exceptional male longevity were identified and called "blue zone" 83 ; ii) longevity clusters in families and occurs among the ascendants of a particular branch of the family 84 . A peculiar characteristic of Sardinian familial longevity is that children born from mothers who later became centenarians had significant lower infant mortality when compared to children born to those women belonging to the same cohorts but who did not became centenarians 85 . Thus, history of familial longevity contributes to increasing the odds for an individual's longevity, as reported in a study of 1,700 sibships from families of centenarians in the New England Centenarian Study 86 .…”

Section: Familial Ecology and The Genetic Of Longevitymentioning

confidence: 99%

Genetics of Human Longevity Within an Eco-Evolutionary Nature-Nurture Framework

Giuliani

Garagnani

Franceschi

2018

Circulation Research

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Genetics of human longevity within an eco-evolutionary nature-nurture framework. -Circulation Research 2018 ; 123(7) : 745-772.The final published version is available online at: https://www.ahajournals.org/ ABSTRACTHuman longevity is a complex trait, and to disentangle its basis has a great theoretical and practical consequence for biomedicine. The genetics of human longevity is still poorly understood, despite a number of investigations that used different strategies and protocols. Here we argue that such rather disappointing harvest is largely due to the extraordinary complexity of the longevity phenotype in humans. The capability to reach the extreme decades of human lifespan appears to be the result of an intriguing mixture of geneenvironment interactions. Accordingly, the genetics of human longevity is here described as a highly context-dependent phenomenon, within a new integrated, ecological and evolutionary perspective, and is presented as a dynamic process, both historically and individually. The available literature has been scrutinized within this perspective, paying particular attention to factors (sex, individual biography, family, population ancestry, social structure, economic status and education, among others) that have been relatively neglected. The strength and limitations of the most powerful and used tools, such as GWAS and whole-genome sequencing, have been discussed, focusing on prominently emerged genes and regions, such as APOE, FOXO3, IL-6, IGF-1, chromosome 9p21, 5q33.3 and somatic mutations among others. The major results of this approach suggest that: i) the genetics of longevity is highly population-specific; ii) small-effect alleles, pleiotropy and the "complex allele timing" likely play a major role; iii) genetic risk factors are age-specific and need to be integrated in the light of the geroscience perspective; iv) a close relationship between genetics of longevity and genetics of age-related diseases (especially cardiovascular diseases) do exist. Finally, the urgent need of a global approach to the largely unexplored interactions between the three genetics of human body, i.e. nuclear, mitochondrial and microbiomes, is stressed. We surmise that the comprehensive approach here presented will help in increasing the above-mentioned harvest.

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Section: Familial Ecology and The Genetic Of Longevitymentioning

confidence: 99%

Genetics of Human Longevity Within an Eco-Evolutionary Nature-Nurture Framework

Giuliani

Garagnani

Franceschi

2018

Circulation Research

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“…Moreover, CO allow to study both genetic and environmental/lifestyle determinants of healthy aging. In fact, human longevity seems to cluster in families enriched in long-lived parents and ancestors, and parents/mothers who later will become centenarians likely adopt more healthy lifestyle for their children [ 5 ]. An impressive and coherent series of epidemiological data from different populations (White Americans from New England, Mormons from Utah, Ashkenazi Jewish living in USA, Icelanders, Japanese from Okinawa, and Netherlanders from Leiden) points out the presence of a strong familiar and genetic component of human longevity.…”

Section: Introductionmentioning

confidence: 99%

Centenarians’ offspring as a model of healthy aging: a reappraisal of the data on Italian subjects and a comprehensive overview

Bucci

Ostan

Cevenini

et al. 2016

Aging

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Within the scenario of an increasing life expectancy worldwide it is mandatory to identify determinants of healthy aging. Centenarian offspring (CO) is one of the most informative model to identify trajectories of healthy aging and their determinants (genetic and environmental), being representative of elderly in their 70th whose lifestyle can be still modified to attain a better health. This study is the first comprehensive investigation of the health status of 267 CO (mean age: 70.2 years) and adopts the innovative approach of comparing CO with 107 age-matched offspring of non-long-lived parents (hereafter indicated as NCO controls), recruited according to strict inclusion demographic criteria of Italian population. We adopted a multidimensional approach which integrates functional and cognitive assessment together with epidemiological and clinical data, including pro- and anti-inflammatory cytokines and adipokines, lipid profile, and insulin resistance. CO have a lower prevalence of stroke, cerebral thrombosis-hemorrhage, hypertension, hypercholesterolemia, and other minor diseases, lower BMI and waist circumference, a better functional and cognitive status and lower plasma level of FT4 compared to NCO controls. We conclude that a multidimensional approach is a reliable strategy to identify the health status of elderly at an age when interventions to modify their health trajectory are feasible.

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“…Epidemiological data from different populations (American whites from New England, Mormons from Utah, Ashkenazi Jews residing in the United States, Icelanders, Japanese from Okinawa, and Dutch from Leiden) show how relatives (parents, siblings, and descendants) of long-lived people have significant survival advantage, an increased chance of being or becoming long-lived, have a lower risk of developing serious age-related diseases, such as cardiovascular and cerebrovascular diseases, diabetes, and cancer [32][33][34][35][36][37][38][39][40], and have a favorable lipoprotein profile [41,42]. Parents who later become NC probably adopt a healthier lifestyle for their children [43]. An interesting study of this type was conducted in the Italian population by Bucci [44].…”

Section: Discussionmentioning

confidence: 99%

Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes or CIAO)

Pizza

Antonini

Marino³

et al. 2020

Medicina

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Background and objectives: Nonagenarians and centenarians (NCs) are an extremely fragile population, particularly in regard to their physical and cognitive function. The aim of this study was to define the neurocognitive profiles among 29 NCs and their 49 younger cohabitants aged 50–75 years from The Cilento Initiative on Aging Outcomes (CIAO) Pilot study in the South of Italy that had provided initial hypotheses regarding positive psychological traits related to exceptional longevity. Materials and Methods: During the home visits, lifestyle information with specific questionnaires, functional autonomy and the neuropsychological Mini Mental Scale Examination (MMSE), and the Alzheimer’s Disease Assessment Scale-Cognitive (ADAS-Cog) scale were obtained by qualified study personnel. The total blood oxidative capacity was also determined by testing the reactive derivative of oxygen metabolites (d-ROM) and by the Biological Antioxidant Potential (BAP). In all individuals, the APOE genotype determination was also performed. Results: All the subjects in both groups showed high adherence to the Mediterranean Diet. None of the NCs had severe cognitive impairment, and a very low incidence of dementia was found. The data obtained on the Activities ed Instrumental Activities of Daily Living (ADL-IADL) scale showed that the majority of NCs (16/29) were autonomous in daily life activities. The comparative assessment of NCs and cohabitants showed no significant differences in the laboratory assessment of oxidative stress and APOE genotype. Conclusions: In the Cilento Region of Southern Italy, NCs seemed to have good cognitive status when compared to younger cohabitants aging 50–65 years without significant differences in oxidative stress markers or APOE genotype. These results might be related to optimal adherence to the Mediterranean diet, although other lifestyle factors and positive personality traits may also contribute to their healthy aging. Further studies on a larger population should be performed to confirm the results of this pilot study.

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Maternal longevity is associated with lower infant mortality

Cited by 7 publications

References 36 publications

Genetics of Human Longevity Within an Eco-Evolutionary Nature-Nurture Framework

Genetics of Human Longevity Within an Eco-Evolutionary Nature-Nurture Framework

Centenarians’ offspring as a model of healthy aging: a reappraisal of the data on Italian subjects and a comprehensive overview

Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes or CIAO)

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