Maternal Long-Term Outcomes after a Pregnancy Complicated by Gestational Diabetes Mellitus

Lauenborg, Jeannet; Crusell, Mie; Mathiesen, Elisabeth R.; Damm, Peter

doi:10.1159/000480177

Cited by 2 publications

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“…По мнению ряда авторов [2,47,48], беременность и диета с высоким содержанием жиров являются не моделями регенерации β-клеток, а моделями их физиологического компенсаторного роста. Изучение путей и механизмов, лежащих в основе этого процесса, может быть использовано в стратегиях регенерации островков при лечении диабета.…”

Section: физиологические модели компенсаторного роста β-клеток у грыз...unclassified

Regeneration of β-cells of the islet apparatus of the pancreas. Literature review

2022

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Diabetes of both type 1 and type 2 is characterized by a progressive loss of β-cell mass, which contributes to the disruption of glucose homeostasis. The optimal antidiabetic therapy would be simple replacement of lost cells, but at present, many researchers have shown that the pancreas (PZ) of adults has a limited regenerative potential. In this regard, significant efforts of researchers are directed to methods of inducing the proliferation of β-cells, stimulating the formation of β-cells from alternative endogenous sources and/or the generation of β-cells from pluripotent stem cells. Factors that regulate β-cell regeneration under physiological or pathological conditions, such as mediators, transcription factors, signaling pathways and potential pharmaceuticals, are also being intensively studied. In this review, we consider recent scientific studies carried out in the field of studying the development and regeneration of insulin-producing cells obtained from exogenous and endogenous sources and their use in the treatment of diabetes. The literature search while writing this review was carried out using the databases of the RSIC, CyberLeninka, Scopus, Web of Science, MedLine, PubMed for the period from 2005 to 2021. using the following keywords: diabetes mellitus, pancreas, regeneration, β-cells, stem cells, diabetes therapy.

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Section: физиологические модели компенсаторного роста β-клеток у грыз...unclassified

Regeneration of β-cells of the islet apparatus of the pancreas. Literature review

2022

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“…Pregnancies with GDM are considered high-risk, as they are associated with a series of adverse outcomes, such as caesarean delivery, preeclampsia, macrosomia, preterm birth, and stillbirth [ 3 ]. Moreover, the pathophysiologic dysregulation that occurs in GDM may also have an impact in later life for both the mother and the offspring; it is a crucial determinant of healthcare cost and influences the quality of life of those affected [ 4 , 5 , 6 , 7 , 8 ]. Additionally, due to the absence of unanimous consensus among guidelines on the diagnosis and management of GDM, a number of cases may escape the appropriate attention.…”

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confidence: 99%

Pre-Pregnancy Adherence to Mediterranean Diet and Risk of Gestational Diabetes Mellitus: A Prospective Cohort Study in Greece

et al. 2023

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Gestational Diabetes Mellitus (GDM) is a growing epidemic affecting pregnant women and their offspring. This study aimed to identify the relationship between adherence to a Mediterranean diet (MD) before conception and the risk of GDM in a contemporary Greek pregnant cohort. A prospective cohort of pregnant women was recruited at the routine first trimester visit. Nutritional intake was evaluated using a population specific validated food frequency questionnaire (FFQ). Pre-pregnancy adherence to MD was derived using two different scoring systems, the Mediterranean diet index score (MDS), and a modified version. Adjusted odds ratios (aOR) were computed using multiple logistic regression models for each score derived. Of 743 participating women, 112 (15.1%) developed GDM. The MDS index showed that scoring 5–9 points (high adherence) was associated with a lower GDM incidence (aOR: 0.57 95% CI (0.32, 0.90), p = 0.02), while the modified MDS index showed no significant association for any level of adherence. Pre-pregnancy consumption of “meat and derivatives” and “fatty meat and processed meat” was associated with a higher risk of GDM, with both scoring systems (p = 0.008, p = 0.004, respectively). A higher adherence to a MD pre-pregnancy, especially with less meat consumption, may have a protective effect on the occurrence of GDM.

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Maternal Long-Term Outcomes after a Pregnancy Complicated by Gestational Diabetes Mellitus

Cited by 2 publications

References 0 publications

Regeneration of β-cells of the islet apparatus of the pancreas. Literature review

Regeneration of β-cells of the islet apparatus of the pancreas. Literature review

Pre-Pregnancy Adherence to Mediterranean Diet and Risk of Gestational Diabetes Mellitus: A Prospective Cohort Study in Greece

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