Maternal LC-PUFA status during pregnancy and child problem behavior: the Generation R Study

Graaff, Jolien C. J. Steenweg-de; Tiemeier, Henning; Basten, Maartje; Rijlaarsdam, Jolien; Demmelmair, Hans; Koletzko, Berthold; Hofman, Albert; Jaddoe, Vincent W. V.; Verhulst, Frank C.; Roza, Sabine J.

doi:10.1038/pr.2014.204

Cited by 41 publications

(40 citation statements)

References 29 publications

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“…Several cohort studies reported a negative relation between maternal n-6/n-3 PUFAs status and infant and child neurodevelopment assessed by various tests [4, 7–9] and these reports partly confirmed our results. The Seychelles Child Development Nutrition Study (SCDS) [4] reported that maternal n-6/n-3 PUFAs in serum was negatively associated with the BSID-II PDI at 9 months of age but not at 30 months.…”

Section: Discussionsupporting

confidence: 91%

“…The EDEN mother-child cohort in France showed that maternal dietary n-6/n-3 PUFAs intakes among never-breastfed children were negatively associated with the MacArthur Communicative Development Inventory (CDI) at 2 years of age and with the ASQ at 3 years of age [8], while the n-6/n-3 PUFAs in colostrum among breastfed children was negatively associated with the ASQ at 3 years of age [9]. Recently, the Generation R study in the Netherlands [7] demonstrated that a higher maternal plasma n-3/n-6 PUFAs was associated with fewer emotional problems in children at 6 years of age.…”

Section: Discussionmentioning

confidence: 99%

“…Cohort studies in Seychelles [4] and France [9], reported that maternal n-6/n-3 PUFAs, in serum and in colostrum, respectively, were negatively associated with the Bayley scales of infant development edition II (BSID-II) at 9 months of age and with the ages and stages questionnaire (ASQ) at 3 years of age, respectively. A recent cohort study in the Netherlands reported that higher maternal DHA and n-3/n-6 PUFAs were associated with fewer emotional problems in children at 6 years [7]. Recent experimental studies suggested that an imbalance in the maternal n-6/n-3 PUFAs and ratio of LA-to-ALA (LA/ALA), induced impaired neocortical neurogenesis in offspring and anxiety-related behavior in adulthood [13, 14].…”

Section: Introductionmentioning

confidence: 99%

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Association between maternal intake of n-6 to n-3 fatty acid ratio during pregnancy and infant neurodevelopment at 6 months of age: results of the MOCEH cohort study

Kim

Lee

et al. 2017

Nutr J

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Background & aimsLong-chain polyunsaturated fatty acids (LC-PUFAs) are essential for infant neurodevelopment. The nutritional adequacy of dietary LC-PUFAs depends not only on the LC-PUFAs intake but also on the n-6 to n-3 fatty acid ratio (n-6/n-3 PUFAs). This study aimed to identify the association between the maternal dietary n-6/n-3 PUFAs and motor and cognitive development of infants at 6 months of age.MethodsWe used data from 960 participants in the Mothers and Children's Environmental Health (MOCEH) study, which is a multi-center prospective cohort study. Dietary intake of pregnant women was assessed by a one-day 24-h recall method. Food consumption of infants was estimated based on the volume of breast milk and weaning foods. The duration of each feed was used to estimate the likely volume of milk consumed. Dietary intake of infants at 6 months was also assessed by a 24-h recall method. Cognitive and motor development of infants at 6 months of age was assessed by the Korean Bayley scales of infant development edition II (BSID-II) including the mental developmental index (MDI) and the psychomotor developmental index (PDI).ResultsMaternal intakes of n-6/n-3 PUFAs and linoleic acid (LA)-to-α-linolenic acid (ALA) ratio (LA/ALA) were 9.7 ± 6.3 and 11.12 ± 6.9, respectively. Multiple regression analysis, after adjusting for covariates, showed that n-6/n-3 PUFAs was negatively associated with both the MDI (β = −0.1674, P = 0.0291) and PDI (β = −0.1947, P = 0.0380) at 6 months of age. These inverse associations were also observed between LA/ALA and both the MDI and PDI (MDI; β = −0.1567; P = 0.0310, PDI; β = −0.1855; P = 0.0367). Multiple logistic regression analysis, with the covariates, showed that infants whose mother’s LA/ALA were ranked in the 2nd, 3rd, and 4th quartile were at approximately twice the risk with more than twice the risk of delayed performance on the PDI compared to the lowest quartile (1st vs. 2nd; OR = 2.965; 95% CI = 1.376 − 6.390, 1st vs. 3rd; OR = 3.047; 95% CI = 1.374 − 6.756 and 1st vs. 4th; OR = 2.551; 95% CI = 1.160 − 5.607).ConclusionsBoth the maternal dietary n-6/n-3 PUFAs and LA/ALA intake were significantly associated with the mental and psychomotor development of infants at 6 months of age. Thus, maintaining low n-6/n-3 PUFAs and LA/ALA is encouraged for women during pregnancy.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between maternal intake of n-6 to n-3 fatty acid ratio during pregnancy and infant neurodevelopment at 6 months of age: results of the MOCEH cohort study

Kim

Lee

et al. 2017

Nutr J

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“…Interventional studies failed to find evidence that prenatal fish-oil (and folic acid) supplementation may influence the cognitive development of children at 6.5 y of age, but a high DHA in maternal erythrocytes at delivery was associated with a Mental Processing Composite Score higher than the 50th percentile in the offspring [25]. Also, associations of maternal LC-PUFA status with child emotional and behavioral problems were found in an epidemiologic study [26]. Nowadays, special formulae for the treatment of CMA are not in line with these characteristics of HM (Table 1).…”

Section: –16: Many More Reasons For Considering Breastfeeding As mentioning

confidence: 99%

Cow’s milk allergy: towards an update of DRACMA guidelines

Fiocchi

Dahda

Dupont

et al. 2016

World Allergy Organization Journal

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BackgroundIn 2010, the diagnosis and treatment of IgE-mediated CMA were systematized in a GRADE guideline.Objectives & methodsAfter 6 years, the state of the knowledge in diagnosis and treatment of CMA has largely evolved. We summarize here the main advances, and exemplify indicating some specific points: studies aimed at better knowledge of the effects of breastfeeding and the production of new special formulae intended for the treatment of CMA. The literature (PubMed/MEDLINE) was searched using the following algorithms: (1) [milk allergy] AND diagnosis; (2) [milk allergy] AND [formul*] OR [breast*], setting the search engine [6-years] time and [human] limits. The authors drew on their collective clinical experience to restrict retrieved studies to those of relevance to a pediatric allergy practice.ResultsSeveral clinical studies did address the possibility to diagnose CMA using new tools in vitro and in vivo, or to diagnose it without any evaluation of sensitization. Some studies also addressed the clinical role of formulae based on milk hydrolysates, soy, or rice hydrolysates in the treatment of CMA. Many studies have elucidated the effects of selective nutrients in breastfed infants on their immunologic and neurologic characteristics.ConclusionsEvidence-based diagnostic criteria should be identified for non-IgE-mediated CMA. Debate is ongoing about the best substitute for infants with CMA. In particular, Hydrolyzed Rice Formulae have been widely assessed in the last six years. In the substitute choice, clinicians should be aware of recent studies that can modify the interpretation of the current recommendations. New systematic reviews and metanalyses are needed to confirm or modify the current DRACMA recommendations.

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“…According to the abovementioned study, higher AA levels were identified in children with behavioral problems. A high maternal DHA and w-3:w-6 ratio were associated with few children with emotional problems [5].…”

Section: Current Evidence Of N-3 Pufas In Health and Diseasementioning

confidence: 96%

The Role of Omega-3 Fatty Acids in Diets

Gómez-Candela¹,

Puchalt²,

Milla³

et al. 2015

Journal of the American College of Nutrition

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The article is a summary of Dra. Carmen Gómez Candela's presentation at the Science in Nutrition 3rd International Congress in Milan, March 2014. The article covers omega-3 fatty acids use in different medical areas and several institutions' opinions in relation to the topic. Omega-3 acids are essential fatty acids. A certain amount of omega-3 is needed in our daily diet; however, the usual consumption is generally less than the recommended amount. Changes in dietary patterns in the course of history have led to deficit levels of omega-3 in the human body. Currently, there is increasing evidence of the benefits of omega-3 in different medical specialities. There are still some gaps regarding its role in illnesses such as dementia, psychiatric disorders, and inflammatory diseases. Nevertheless, stronger evidence is being proved in cardiovascular diseases and cancer. This article provides a reflection on possible ways to increase omega-3 daily consumption and the constraints associated with food with high contents of heavy metals, which, in turn, are also rich in omega-3s.

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Maternal LC-PUFA status during pregnancy and child problem behavior: the Generation R Study

Cited by 41 publications

References 29 publications

Association between maternal intake of n-6 to n-3 fatty acid ratio during pregnancy and infant neurodevelopment at 6 months of age: results of the MOCEH cohort study

Association between maternal intake of n-6 to n-3 fatty acid ratio during pregnancy and infant neurodevelopment at 6 months of age: results of the MOCEH cohort study

Cow’s milk allergy: towards an update of DRACMA guidelines

The Role of Omega-3 Fatty Acids in Diets

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