Maternal Iodine Intake and Neurodevelopment of Offspring: The Japan Environment and Children’s Study

Hisada, Aya; Takatani, Rieko; Yamamoto, Midori; Nakaoka, Hiroko; Sakurai, Kenichi; Mori, Chisato

doi:10.3390/nu14091826

Cited by 6 publications

(10 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…So that better iodine status contributes to improving thinking skills and agility in learning subjects at school. However, this is not in line with the research in school children aged 6-10 years that iodine status is not significantly related to cognitive school children (Hisada et al, 2022).…”

Section: Volcontrasting

confidence: 92%

Iodine Intake, UIE Levels, Nutritional Status and Academic Achievements in School-Age Children in Magelang, Central Java

Arika

2022

Contagion

View full text Add to dashboard Cite

<div><table cellspacing="0" cellpadding="0" align="left"><tbody><tr><td align="left" valign="top"><p><em>Iodine deficiency in school children is estimated at 25% worldwide. Complete brain development occurs at the age of 7 years and the development of cognitive function can be increased until 15 years with normally iodine status, namely adequate intake of iodine and Urinary Iodine Excretion (UIE). This study aims to analyze the relationship between iodine intake, UIE, height for age and academic achievements in school-age children. This research was an analytic observational study with a cross sectional design. This research was conducted in 4 elementary schools in Pakis District in March 2019. The samples were selected by random sampling, totaling 177 subjects. The dependent variable was the school's academic achievements in the form of midterm exam scores for maths, arts and sports. While the independent variables were iodine intake, UIE and height for age. The assessment of iodine intake was using a 24-hour recall form and interpreted using the 2007 Nutrisurvey application. The analysis method for UIE is the acid digestion method. Height for age is a child's nutritional status that can be determined based on anthropometric measurements. Academic achievements is learning outcomes as measured by midterm exam scores iin maths, arts, culture and sports. Data was analyzed by Linear Regression. Iodine intake increased math (b=0.01; p=0.014), art and sport (b=0.03; p=<0.001) scores. UIE levels increased math (b=0.01; p=0.001), art (b=0.01; p=0.002) and sport (b=0.01; p=0.003) scores. Height for age increased sport scores (b=1.58; p=0.010). The conclusion of this study is that height for age increase sports ability and iodine intake also UIE can increase academic achievements.</em></p><p> </p></td></tr></tbody></table></div><strong><em>Keyword: Academic Achievements, Height for Age, Iodine Intake, UIE </em></strong>

show abstract

Section: Volcontrasting

confidence: 92%

Iodine Intake, UIE Levels, Nutritional Status and Academic Achievements in School-Age Children in Magelang, Central Java

Arika

2022

Contagion

View full text Add to dashboard Cite

show abstract

“…In most regions, habitual diets provide a low normal iodine supply and are more prone to induce iodine deficiency than excess [ 52 ]. Nevertheless, people living in some regions could be exposed to extraordinary iodine overload due to their diet.…”

Section: Iodine Excessmentioning

confidence: 99%

Iodine Deficiency and Iodine Prophylaxis: An Overview and Update

et al. 2023

View full text Add to dashboard Cite

The thyroid gland requires iodine to synthesize thyroid hormones, and iodine deficiency results in the inadequate production of thyroxine and related thyroid, metabolic, developmental, and reproductive disorders. Iodine requirements are higher in infants, children, and during pregnancy and lactation than in adult men and non-pregnant women. Iodine is available in a wide range of foods and water and is susceptible to almost complete gastric and duodenal absorption as an iodide ion. A healthy diet usually provides a daily iodine consumption not exceeding 50% of the recommended intake. Iodine supplementation is usually necessary to prevent iodine deficiency disorders (IDDs), especially in endemic areas. The community-based strategy of iodine fortification in salt has eradicated IDDs, such as endemic goiter and cretinism, in countries providing adequate measures of iodine prophylaxis over several decades in the 20th century. Iodized salt is the cornerstone of iodine prophylaxis in endemic areas, and the continuous monitoring of community iodine intake and its related clinical outcomes is essential. Despite the relevant improvement in clinical outcomes, subclinical iodine deficiency persists even in Western Europe, especially among girls and women, being an issue in certain physiological conditions, such as pregnancy and lactation, and in people consuming unbalanced vegetable-based or salt-restricted diets. Detailed strategies to implement iodine intake (supplementation) could be considered for specific population groups when iodized salt alone is insufficient to provide adequate requirements.

show abstract

“…A 2017 Norwegian observational study in a MMID population found that low iodine intake from diet was associated with offspring language delay, behavioral problems, and fine motor skills at age three, but MIS did not affect outcomes [12]. A 2022 observational study in Japan evaluated iodine intake through diet along with kelp and seaweed in a marginally iodine-sufficient population and found an increased risk for delay in communication, fine motor, and problem solving at 1 and 3 years of age in those with the lower quintile for intake compared with those with the highest [74]. However, an observational study in India did not find an association between maternal UIC and mental and motor development, although in an iodine-sufficient population [75].…”

Section: Iodine and Child Neurodevelopmental Outcomesmentioning

confidence: 99%

An update: maternal iodine supplementation, thyroid function tests, and child neurodevelopmental outcomes

Nguyen

2023

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

View full text Add to dashboard Cite

Purpose of review The impact of maternal iodine supplementation (MIS) during pregnancy on thyroid function and child neurodevelopmental outcomes in areas of mild-to-moderate iodine deficiency (MMID) remains unclear. Recent findings Despite growing success of salt iodization programs, a 2022 meta-analysis found that 53% of pregnant patients worldwide continue to have insufficient iodine intake during pregnancy. A 2021 randomized controlled trial (RCT) found that MIS in women with mild iodine deficiency led to iodine sufficiency and positive effects on maternal thyroglobulin. A 2021 cohort study of MIS initiated prior to pregnancy was associated with lower thyroid-stimulating hormone (TSH), higher FT3, and FT4. Other cohort studies, however, found that neither salt iodization nor MIS were adequate to meet pregnancy iodine needs. Data have been mixed regarding maternal iodine status and pregnancy outcomes in patients of MMID. Meta-analyses have not shown any clear benefit on infant neurocognitive outcomes with MIS of MMID patients. A 2023 meta-analysis found that the prevalence of excess iodine intake in pregnancy was 52%. Summary MMID continues to exist during pregnancy. Salt iodization alone may be insufficient to ensure adequate iodine status during pregnancy. There is an absence of high-quality data to support routine MIS in areas of MMID. However, patients with specialized diets (vegan, nondairy, no seafood, noniodized salt, and so on) may be at risk for inadequate iodine status in pregnancy. Excess iodine intake can be detrimental to the fetus and should be avoided during pregnancy.

show abstract

Maternal Iodine Intake and Neurodevelopment of Offspring: The Japan Environment and Children’s Study

Cited by 6 publications

References 43 publications

Iodine Intake, UIE Levels, Nutritional Status and Academic Achievements in School-Age Children in Magelang, Central Java

Iodine Intake, UIE Levels, Nutritional Status and Academic Achievements in School-Age Children in Magelang, Central Java

Iodine Deficiency and Iodine Prophylaxis: An Overview and Update

An update: maternal iodine supplementation, thyroid function tests, and child neurodevelopmental outcomes

Contact Info

Product

Resources

About