Maternal intake of vitamin D during pregnancy and risk of advanced beta cell autoimmunity and type 1 diabetes in offspring

Marjamäki, Liisa; Niinistö, Sari; Kenward, Michael G.; Uusitalo, Liisa; Uusitalo, Ulla; Ovaskainen, Marja-Leena; Kronberg-Kippilä, Carina; Simell, Olli; Veijola, Riitta; Ilonen, Jorma; Knip, Mikael; Virtanen, Suvi Μ.

doi:10.1007/s00125-010-1734-8

Cited by 106 publications

(86 citation statements)

References 30 publications

(53 reference statements)

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“…Some evidence has also been reported for an association between vitamin D supplementation during pregnancy and a decreased risk of type 1 diabetes [9], or reduced development of beta cell-specific autoantibodies [7] in the offspring. In other studies, however, no association was seen between maternal intake of vitamin D during pregnancy and risk of advanced beta cell autoimmunity [10] or type 1 diabetes [6] in the offspring. In these studies, vitamin D status was estimated from calculated supply from the diet and vitamin D supplements, without information on serum vitamin D levels.…”

Section: Introductionmentioning

confidence: 76%

Serum 25-hydroxyvitamin D level during early pregnancy and type 1 diabetes risk in the offspring

et al. 2012

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Aims/hypothesis Vitamin D deficiency during the fetal period or infancy is one of the suggested environmental factors for type 1 diabetes and for its increasing incidence. To test this hypothesis we compared serum 25-hydroxyvitamin D (25(OH)D) levels during early pregnancy in mothers of children who subsequently developed type 1 diabetes (case mothers) with mothers of non-diabetic healthy children (control mothers) of the same age. Methods Children with type 1 diabetes were identified from the nationwide prescription register. 25(OH)D concentration was measured from serum samples collected during the first trimester of pregnancy from all Finnish women (Finnish Maternity Cohort). A total of 343 case mothers and 343 control mothers were included in the study. Samples were collected throughout the year. Samples from case and control mothers were matched on the day of collection. Results Mean 25(OH)D levels in case mothers (43.9 nmol/l) and control mothers (43.7 nmol/l) were not different. Of all mothers, 481 (70.1%) were vitamin D-deficient or -insufficient. Conclusions/interpretation No difference was found in serum 25(OH)D concentrations during first trimester of pregnancy between mothers whose children later on developed type 1 diabetes, and mothers of non-diabetic ' healthy' children of the same age. It is difficult to detect possible effects of mothers' vitamin D deficiency during early pregnancy on the development of type 1 diabetes in the offspring in this population, as such a large proportion of mothers were vitamin D-deficient or -insufficient.

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Section: Introductionmentioning

confidence: 76%

Serum 25-hydroxyvitamin D level during early pregnancy and type 1 diabetes risk in the offspring

et al. 2012

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“…However, more recently this has been expanded to include non-classical actions of vitamin D and childhood illness. These include brain development and adult mental health [203][204][205][206][207] , autoimmune disease [208][209][210] , and asthma [211][212][213] . At present the hypothesized role of vitamin D in fetal programming is based entirely on epidemiology.…”

Section: Maternalmentioning

confidence: 99%

Vitamin D and Human Pregnancy

Grayson¹,

Hewison

2011

Fet. Matern. Med. Rev.

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At the end of 2007, Time magazine listed the “benefits of vitamin D” as one of its top 10 medical breakthroughs for that year. Since then there has been a remarkable upsurge of interest in vitamin D, with new research advances seemingly published on a weekly basis. In particular, there has been increasing awareness of the variability of vitamin D status in populations across the globe and, significantly, a growing debate about the need for revised parameters for vitamin D supplementation. Although sub-optimal vitamin D is likely to be a widespread problem for 21stcentury societies, it is also clear that some groups are at much greater risk of low vitamin D status. Prominent amongst these are pregnant women and the aim of the following review article will be to discuss this problem in further detail with specific emphasis on its potential physiological and clinical impact.

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“…Cytochrome P450, family 27, subfamily (DIPP), in which the dietary habits of Finnish women were meticulously examined and linked to the onset of autoimmunity in their (genetically at risk) offspring [1]. The straightforward answer from this impressive study is that there was no correlation between the amount of vitamin D consumed by the mother and the appearance of islet autoantibodies in the blood of their offspring in the first year of life.…”

Section: Cyp27b1mentioning

confidence: 99%

“…One striking conclusion from the present study is the fact that recommendations on dietary intakes and supplements are very hard to implement, even in a special population such as pregnant women. In fact, only 15% stated that they took more than 10 µg (400 international units [IU]) of vitamin D per day, and only 30% of women actually took supplements [1].…”

Section: Cyp27b1mentioning

confidence: 99%

Vitamin D and diabetes: the devil is in the D-tails

Mathieu

2010

Diabetologia

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Maternal intake of vitamin D during pregnancy and risk of advanced beta cell autoimmunity and type 1 diabetes in offspring

Abstract: Aims/hypothesis We evaluated the intake of vitamin D by pregnant Finnish women and examined associations between maternal intake of vitamin D and the development of advanced beta cell autoimmunity and type 1 diabetes in their offspring.

Cited by 106 publications

References 30 publications

Serum 25-hydroxyvitamin D level during early pregnancy and type 1 diabetes risk in the offspring

Serum 25-hydroxyvitamin D level during early pregnancy and type 1 diabetes risk in the offspring

Vitamin D and Human Pregnancy

Vitamin D and diabetes: the devil is in the D-tails

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