Maternal intake of flaxseed-based diet (Linum usitatissimum) on hippocampus fatty acid profile: Implications for growth, locomotor activity and spatial memory

Fernandes, Flávia de Souza; Souza, Anderson Santos; Carmo, Maria das Graças Tavares do; Boaventura, Gilson Teles

doi:10.1016/j.nut.2010.11.001

Cited by 28 publications

(21 citation statements)

References 59 publications

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“…Memory acquisition is a process involving molecular and cellular events activated immediately after the training session and after a few hours to a few days of the task, occurring in specific brain regions such as the hippocampus (Bekinschtein et al, 2010;Medina et al, 2008;Bach et al, 2014). Neurogenesis especially occurs in the dentate gyrus of the hippocampus, where recently formed neurons are recruited to pre-existing neural circuits, being involved in the hippocampus-dependent learning processes (Drapeau et al, 2003;Fernandes et al, 2011). Thus, a deficiency in FA composition in the maternal diet is associated with cognitive impairment and mental illnesses such as Alzheimer's disease, attention-deficit hyperactivity disorder (ADHD), depression and schizophrenia (Haag, 2003;Ozias et al, 2007;Mucci et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, DHA levels (C22:6n3) were about 36% lower in this group compared to the other groups. The amount of DHA in the brain was increased in the offspring of animals treated with flaxseed diet, being correlated with better spatial memory performance (Fernandes at al., 2011). These fatty acids are essential for brain development and memory because they modulate synaptic plasticity, improving learning ability.…”

Section: Docasa-mentioning

confidence: 99%

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Maternal intake of cashew nuts accelerates reflex maturation and facilitates memory in the offspring

Melo

Pereira

Sousa

et al. 2017

Intl J of Devlp Neuroscience

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Essential fatty acids, being indispensable during the stages of pregnancy, lactation and infancy influence the transmission of nerve impulses and brain function, and cashew nuts are a good source of these fatty acids. The objective of this study was to evaluate the effects of cashew nut consumption on reflex development, memory and profile of fatty acids of rat offspring treated during pregnancy and lactation. The animals were divided into three groups: Control (CONT), treated with 7% lipid derived from soybean oil; Normolipidic (NL) treated with 7% lipids derived from cashew nuts; and Hyperlipidic (HL) treated with 20% lipids derived from cashew nuts. Reflex ontogeny, Open-field habituation test and the Object Recognition Test (ORT) were assessed. The profile of fatty acids in the brain was carried out when the animals were zero, 21 and 60days old. Accelerated reflex maturation was observed in animals treated with cashew nuts (p<0.05). NL presented better memory in the Open-field habituation test; the NL and HL showed improvement of short-term memory in the ORT, but long term damage in HL (p<0.05). The results of the lipid profile of the brain at the end of the experiment showed an increase in levels of saturated fatty acids and less Docosahexaenoic acid (DHA) in animals of the HL. The data showed that maternal consumption of cashew nuts can accelerate reflex maturation and facilitate memory in offspring when offered in adequate quantities.

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Section: Discussionmentioning

confidence: 99%

Section: Docasa-mentioning

confidence: 99%

Maternal intake of cashew nuts accelerates reflex maturation and facilitates memory in the offspring

Melo

Pereira

Sousa

et al. 2017

Intl J of Devlp Neuroscience

View full text Add to dashboard Cite

show abstract

“…Further understanding has been attempted by many suggested hypothesis on how a myriad of environmental factors can affect memory acquisition. Daily hours of sleep, diet composition, practice of physical activity and lifestyle are some of the factors that have been studied (Fernandes et al, 2011; Binder et al, 2012; Espinosa et al, 2013; Lee et al, 2013; Lovatel et al, 2013). Dysfunction in hippocampal neurogenesis has been correlated recently in the pathophysiology of cognitive disorders, such as depression, anxiety and even schizophrenia.…”

Section: The Hippocampus and The Olfactoy Bulb: General Anatomy Anmentioning

confidence: 99%

Novel functions of GABA signaling in adult neurogenesis

Pontes

Zhang

2013

Front. Biol.

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Neurotransmitter gamma-aminobutiric acid (GABA) through ionotropic GABAA and metabotropic GABAB receptors plays key roles in modulating the development, plasticity and function of neuronal networks. GABA is inhibitory in mature neurons but excitatory in immature neurons, neuroblasts and neural stem/progenitor cells (NSCs/NPCs). The switch from excitatory to inhibitory occurs following the development of glutamatergic synaptic input and results from the dynamic changes in the expression of Na+/K+/2Cl− co-transporter NKCC1 driving Cl− influx and neuron-specific K+/Cl− co-transporter KCC2 driving Cl− efflux. The developmental transition of KCC2 expression is regulated by Disrupted-in-Schizophrenia 1 (DISC1) and brain-derived neurotrophic factor (BDNF) signaling. The excitatory GABA signaling during early neurogenesis is important to the activity/experience-induced regulation of NSC quiescence, NPC proliferation, neuroblast migration and newborn neuronal maturation/functional integration. The inhibitory GABA signaling allows for the sparse and static functional networking essential for learning/memory development and maintenance.

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“…lignans, in addition to reduction of body mass reduces levels of lipid peroxide in the hippocampus. Studies on flax feed dam suggest that improvement in hippocampus ALA and DHA concentration results in reduction of spatial memory inhibitors thus increases learning ability of flaxseed feed dams [30]…”

Section: Prevention In Cancermentioning

confidence: 99%

Flaxseed- Bioactive compounds and health significance

Mishra¹

2013

IOSRJHSS

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Flaxseed is extensively consumed in three ways: whole seed, powder and flaxseed oil. In the last decade, flaxseed has garnered attention due to its reported health benefits. Studies have shown that the benefits of flaxseed are believed to be due three important components found in flaxseeds, α-linolenic acid (ALA), lignans, and fiber. The presence of these bioactive compounds helps in the prevention of cardiovascular diseases, diabetes, memory loss, and constipation. The phenolic compounds of flaxseed help in reduction of the fasting plasma glucose levels. Flaxseed contains biologically active estrogenic compounds called phytoestrogens which helps in decreasing cell proliferation and prevents cancer. Higher levels of flaxseed are associated with prevention of memory loss and constipation. Flaxseed also contains several non-nutritional compounds such as cyanogenic glycosides, cadmium, trypsin inhibitors and phytic acid that negatively influence health and well-being.

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Maternal intake of flaxseed-based diet (Linum usitatissimum) on hippocampus fatty acid profile: Implications for growth, locomotor activity and spatial memory

Abstract: Flaxseed during perinatal and postweaning periods improves spatial memory to the detriment of growth. These findings indicate that there must be caution in encouraging the maternal intake of flaxseed during pregnancy and lactation.

Cited by 28 publications

References 59 publications

Maternal intake of cashew nuts accelerates reflex maturation and facilitates memory in the offspring

Maternal intake of cashew nuts accelerates reflex maturation and facilitates memory in the offspring

Novel functions of GABA signaling in adult neurogenesis

Flaxseed- Bioactive compounds and health significance

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