Maternal inheritance of glucose intolerance via oocyte TET3 insufficiency

Chen, Bin; Du, Yongsheng; Zhu, Hong; Sun, Meiling; Wang, Chao; Cheng, Yi; Pang, Haijun; Ding, Guo-Hui; Gao, Juan; Tan, Ya‐Jing; Tong, Xiaomei; Lv, Peng; Zhou, Feng; Zhan, Qiwei; Xu, Zhi-Mei; Wang, Li; Luo, Donghao; Ye, Yinghui; Jin, Li; Zhang, Songying; Zhu, Yu; Lin, Xiaona; Wu, Yanting; Jin, Long-Fei; Zhou, Yin; Yan, Caochong; Sheng, Jian‐Zhong; Flatt, Peter; Xu, Guoliang; Huang, He‐Feng

doi:10.1038/s41586-022-04756-4

Cited by 55 publications

(70 citation statements)

References 75 publications

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“…Taken together, the study by Chen et al 5 . revealed the unequivocal association between pregestational hyperglycemia and the susceptibility of offspring to metabolic disorders.…”

Section: Figurementioning

confidence: 78%

“…The research article 5 suggested and verified the concept of pregestational hyperglycemia sensitizing the progeny to metabolic diseases in humans and mice, and further exposed the critical epigenetic regulator TET3 for the first time. The IVF‐ET and pronucleus track mainly avoids the influence of gestation and maternal metabolism, highlighting the effect of pre‐pregnancy and ensuring full‐chain traceability.…”

Section: Figurementioning

confidence: 90%

“…A recent study in Nature has reported that preconception hyperglycemia is likely to render offspring susceptible to metabolic abnormities via maternal germline‐dependent epigenetic inheritance 5 . To distinguish the oocyte‐derived phenotypic transition, the authors performed in vitro fertilization (IVF) from a normal male mouse with hyperglycemic females (HG mice) and embryo transfer (ET) to normal acceptors to exclude the influence of gestational hyperglycemia on the health of progeny.…”

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confidence: 99%

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Hyperglycemia‐mediated oocyte TET3 insufficiency predisposes offspring to glucose intolerance

Weng

2022

J of Diabetes Invest

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“…Taken together, the study by Chen et al 5 . revealed the unequivocal association between pregestational hyperglycemia and the susceptibility of offspring to metabolic disorders.…”

Section: Figurementioning

confidence: 78%

Section: Figurementioning

confidence: 90%

mentioning

confidence: 99%

See 1 more Smart Citation

Hyperglycemia‐mediated oocyte TET3 insufficiency predisposes offspring to glucose intolerance

Weng

2022

J of Diabetes Invest

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“…It has been shown that pregestational hyperglycemia renders the offspring more vulnerable to glucose intolerance. The expression of TET3 dioxygenase, responsible for 5-methylcytosine oxidation and DNA demethylation in the zygote, is decreased in oocytes from a mouse model of hyperglycaemia (HG mice) and in people with diabetes [ 318 ].…”

Section: Fetal Epigenetics Dependence On Maternal Lifestyle and Envir...mentioning

confidence: 99%

An Interplay between Epigenetics and Translation in Oocyte Maturation and Embryo Development: Assisted Reproduction Perspective

2022

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Germ cell quality is a key prerequisite for successful fertilization and early embryo development. The quality is determined by the fine regulation of transcriptomic and proteomic profiles, which are prone to alteration by assisted reproduction technology (ART)-introduced in vitro methods. Gaining evidence shows the ART can influence preset epigenetic modifications within cultured oocytes or early embryos and affect their developmental competency. The aim of this review is to describe ART-determined epigenetic changes related to the oogenesis, early embryogenesis, and further in utero development. We confront the latest epigenetic, related epitranscriptomic, and translational regulation findings with the processes of meiotic maturation, fertilization, and early embryogenesis that impact the developmental competency and embryo quality. Post-ART embryo transfer, in utero implantation, and development (placentation, fetal development) are influenced by environmental and lifestyle factors. The review is emphasizing their epigenetic and ART contribution to fetal development. An epigenetic parallel among mouse, porcine, and bovine animal models and human ART is drawn to illustrate possible future mechanisms of infertility management as well as increase the awareness of the underlying mechanisms governing oocyte and embryo developmental complexity under ART conditions.

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“…In a recent paper published in Nature , Chen et al provide a new perspective on how glucose tolerance of the offspring is affected by pregestational hyperglycaemia. 1 They showed that oocytes isolated from hyperglycemic mice transmit the impaired glucose homeostasis to the offspring via epigenetic modifications, and insufficiency of oocyte TET3 dioxygenase is indispensable for this process.…”

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confidence: 99%

Oocyte TET3: an epigenetic modifier responsible for maternal inheritance of glucose intolerance

Jiang

Xiao

Guo

2022

Sig Transduct Target Ther

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Maternal inheritance of glucose intolerance via oocyte TET3 insufficiency

Cited by 55 publications

References 75 publications

Hyperglycemia‐mediated oocyte TET3 insufficiency predisposes offspring to glucose intolerance

Hyperglycemia‐mediated oocyte TET3 insufficiency predisposes offspring to glucose intolerance

An Interplay between Epigenetics and Translation in Oocyte Maturation and Embryo Development: Assisted Reproduction Perspective

Oocyte TET3: an epigenetic modifier responsible for maternal inheritance of glucose intolerance

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