2020
DOI: 10.3390/v12091003
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Maternal Influenza A Virus Infection Restricts Fetal and Placental Growth and Adversely Affects the Fetal Thymic Transcriptome

Abstract: Maternal influenza A viral infections in humans are associated with low birth weight, increased risk of pre-term birth, stillbirth and congenital defects. To examine the effect of maternal influenza virus infection on placental and fetal growth, pregnant C57BL/6 mice were inoculated intranasally with influenza A virus A/CA/07/2009 pandemic H1N1 or phosphate-buffered saline (PBS) at E3.5, E7.5 or E12.5, and the placentae and fetuses collected and weighed at E18.5. Fetal thymuses were pooled from each litter. Pl… Show more

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Cited by 15 publications
(10 citation statements)
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“…A link has been established between maternal influenza infections and pre-term birth, low birth weight, congenital defects of the heart, cardiovascular disease as adults, and neurological and behavioral abnormalities [ 137 ]. In mice, influenza virus infection impairs the development of the fetal immune system and causes the downregulation of the expression of the MAL gene in developing fetal thymus [ 138 ]. However, since MAL is expressed neither in adult thymus nor peripheral T cells in mice [ 45 ], it is not clear that this effect is related to the observed defects in immune system development.…”
Section: Mal In Other Cell Systems and Processesmentioning
confidence: 99%
“…A link has been established between maternal influenza infections and pre-term birth, low birth weight, congenital defects of the heart, cardiovascular disease as adults, and neurological and behavioral abnormalities [ 137 ]. In mice, influenza virus infection impairs the development of the fetal immune system and causes the downregulation of the expression of the MAL gene in developing fetal thymus [ 138 ]. However, since MAL is expressed neither in adult thymus nor peripheral T cells in mice [ 45 ], it is not clear that this effect is related to the observed defects in immune system development.…”
Section: Mal In Other Cell Systems and Processesmentioning
confidence: 99%
“…Fifth, our population was not compared with pregnant women with severe ARDS who did not receive ECMO. Lastly, 22 out of 24 cases were secondary to influenza or COVID-19 pneumonia, with potential direct fetal effects of the viruses [ 34 , 35 ].…”
Section: Discussionmentioning
confidence: 99%
“…Despite the fact that the genome of the SARS-COV-2 virus differs from that of influenza cases, some miRNAs are present in them as well, which are also prone to bind to the 5 UTR region of the SARS-COV-2 mRNA sequence. These interactions were discovered with the hsa-miR-6873–5p [ 28 ] and the hsa-miR-4276 [ 27 ]. Other types of miRNAs, such as the hsa-miR-7111–5p, which binds the HOXC8 gene and up-regulates it, are also found in diseases that could result in co-morbidity in SARS-COV virus scenarios [ 29 ].…”
Section: Discussionmentioning
confidence: 99%