Maternal influences on milk intake in SHR and WKY pups

Rose, James L.; McCarty, Richard

doi:10.1016/0031-9384(94)90321-2

Cited by 25 publications

(15 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite spending more time with their litters, SHR dams delivered less milk to SHR and WKY pups during the early part of the preweanling phase, compared with WKY dams. This pattern of milk delivery to SHR and WKY pups in the present study is in agreement with the only other, limited, report on pup feeding, which estimated milk delivery on postnatal days 7 and 14 alone ( Rose & McCarty 1994). However, this study had a number of methodological problems, which included fasting of the pups prior to feeding, failure to induce micturition prior to the test feed and repeated disturbance of the litter to weigh the pups, which we have controlled for in the present study.…”

Section: Discussionsupporting

confidence: 93%

Maternal nursing behaviour and the delivery of milk to the neonatal spontaneously hypertensive rat

Gouldsborough

Black

Johnson

et al. 1998

Acta Physiologica Scandinavica

View full text Add to dashboard Cite

Fostering spontaneously hypertensive rat (SHR) pups to Wistar-Kyoto (WKY) dams permanently lowers their adult blood pressure. SHR dams show increased nursing behaviour and the SHR pup displays an exaggerated pressor response to milk ingestion. We have therefore measured pup feeding rates and dam milk secretion rates in SHR and WKY dams nursing natural and foster litters. Maternal behaviour displayed by SHR and WKY dams nursing natural or foster litters and the milk delivery rate to non-fasted pups were measured over postnatal days 1-21. Total milk yield by SHR and WKY dams at postnatal day 6 was measured by comparing the relative weights of milk filled and empty mammary tissue. Fostering SHR pups to WKY dams significantly lowered their mean arterial blood pressure compared with naturally reared SHR pups. SHR dams nursing their natural litters spent more time nursing and less time away from their litters than WKY dams. This difference in behaviour was reduced when dams nursed pups of the opposite strain. SHR dams delivered less milk compared with WKY dams, regardless of pup strain. Total milk yield by SHR dams was significantly lower than that of WKY dams at postnatal day 6, despite comparable mammary tissue mass, suggesting that milk intake by the SHR pup is limited by milk availability, rather than an attenuated maternal response to pup suckling stimuli. The antihypertensive effect of fostering SHR pups to WKY dams may therefore reflect an increase in milk intake during a critical period of growth and development.

show abstract

Section: Discussionsupporting

confidence: 93%

Maternal nursing behaviour and the delivery of milk to the neonatal spontaneously hypertensive rat

Gouldsborough

Black

Johnson

et al. 1998

Acta Physiologica Scandinavica

View full text Add to dashboard Cite

show abstract

“…In an analysis of line differences in the 13th generation colony group, High-USV-line pups weighed signi®cantly more than Random-line pups (p`0X05), and tended to weigh more than Low-line pups (p 0X10). This is a trend seen in cross-fostering studies in both mice and rats, in that maternal strain effects seem to be important to pup weight gain, accounted for behaviorally or in terms of milk content (e.g., in mice: Carlier et al, 1982;Ragueneau, 1987;in rats: McCarty, Tong, & Forsythe, 1992;Rose & McCarty, 1994), although differences in these effects are, at least in part, driven by differences in pup characteristics (Cierpal, Murphy, & McCarty, 1990). Taken together, these ®ndings suggest that High-line dams contribute more to the weight gain of their pups than mothers of the other two lines, but only if they are nursing High-line pups (for Low-line pups reared by High-line dams did not weigh more than when fostered in-line).…”

Section: Discussionmentioning

confidence: 93%

Selective breeding for infant vocal response: A role for postnatal maternal effects?

Brunelli

Hofer

Weller

2001

Developmental Psychobiology

View full text Add to dashboard Cite

N:NIH rats were selectively bred on the basis of high or low rates of ultrasonic vocalization (USV) response to isolation at 10 days of age (Brunelli et al., 1997: Dev Psychobiol 31:255-265). To examine the possibility of postnatal maternal effects in the generational transmission of divergent traits, pups were cross-fostered shortly after birth between dams of the two lines (Low- and High-USV). Controls were fostered to dams of the same line (in-fostered). Additional (population) control data were obtained from the entire 13th generation of the selectively bred lines. USV rates of cross-fostered pups in each line were not significantly different from rates of in-fostered pups of the same line. High USV line pups cross-fostered to Low USV line dams weighed significantly less than in-fostered pups, on the day of testing. The results provide no evidence for a postnatal maternal contribution to the USV phenotype. Prenatal and/or perinatal maternal effects have not been ruled out.

show abstract

“…10,11 Different maternal nutritional environments may play a role in determining growth rate, BP and subsequent pathophysiology. 12,13 Maternal nursing behavior and nutritional delivery can be factors in SHR rats.…”

Section: Introductionmentioning

confidence: 99%

Wistar-Kyoto and spontaneously hypertensive rat blood pressure after embryo transfer into different wombs and cross-suckling

Lee

Azar

2010

Exp Biol Med (Maywood)

View full text Add to dashboard Cite

Blood pressure (BP) varies based on genetic and environmental factors. To test genetic and environmental influences on body weight (BW) and BP, one-cell homozygous embryos were transferred into spontaneously hypertensive (SHR, pup:shr) or (Wistar-Kyoto normotensive [WKY], pup:wky) normotensive rats' oviducts (embryos: s,w; oviduct-uterine: S,W), cross-suckled at birth (nurses S,W) and weaned to normal diets at day-21. BP at day-120 was measured by radiotelemetry and analyzed by methods of linear least square rhythmometry and analysis of variance. Genetics dominantly affected shr BP, causing it to be significantly higher at birth (24.6 ± 1.8 in sS versus 21.8 ± 1.7 mmHg in wW, P < 0.005), and at day-120 (198 ± 0.5 in sSS versus 127 ± 0.2 mmHg in wWW, P < 0.001), with lower BW than those of wky (5.3 ± 0.2 versus 5.7 ± 0.2 g at birth, 332 ± 5 versus 404 ± 6 g at day-120, both P < 0.001). Surprisingly, uterine-suckling milieus lowered shr BP significantly at day-120 (198 ± 0.5 in sSS versus 178 ± 0.5, 147 ± 0.6, 179 ± 0.5 mmHg in sSW, sWS, sWW, respectively, all P < 0.01). BP was slightly elevated when wky-genetics were implanted into the S-uterine by 4 mmHg (wSW, P < 0.05), whereas implanting shr embryos into the W-uterine environment (sWS) lowered BP by 51 mmHg (P < 0.001). In summary, the hypertensive shr-strain showed significantly lower BP when provided with an WKY-uterine environment and/or by WKY-nursing mothers, indicating that environment can modify genetic influences; yet the shr MESORs (rhythm-adjusted 24-h mean: midline estimating statistic of rhythm) lowered by WKY environments remained above MESORs encountered in wky-donors.

show abstract

Maternal influences on milk intake in SHR and WKY pups

Cited by 25 publications

References 27 publications

Maternal nursing behaviour and the delivery of milk to the neonatal spontaneously hypertensive rat

Maternal nursing behaviour and the delivery of milk to the neonatal spontaneously hypertensive rat

Selective breeding for infant vocal response: A role for postnatal maternal effects?

Wistar-Kyoto and spontaneously hypertensive rat blood pressure after embryo transfer into different wombs and cross-suckling

Contact Info

Product

Resources

About