Maternal infection-induced white matter injury is reduced by treatment with interleukin-10

Rodts-Palenik, Sheryl; Pang, Yi; Thigpen, Brad; Cai, Zhengwei; Rhodes, Philip; Martin, James N.; Granger, Joey P.; Bennett, William A.

doi:10.1016/j.ajog.2003.10.026

Cited by 12 publications

(15 citation statements)

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“…Other studies have demonstrated an association between intrauterine infections, increased fetal blood and neural tissue concentrations of proinflammatory cytokines, and incidence of cerebral tissue damage (Yoon et al, 1997(Yoon et al, , 2003Duggan et al, 2001). Similar findings were observed in experimental studies with pregnant rats (Cai et al, 2000;Rodts-Palenik et al, 2004). Whereas several studies have reported a greater incidence of septicemia in neonatal foals born to mares with uterine infections (Raisis et al, 1996;Gayle et al, 1998;Stewart et al, 2002) and that foals with increased serum TNFa activity had greater mortality rates (Morris and Moore, 1991), no light-emitting bacteria were detected in the fetal foal brain (Ryan et al, 2010a).…”

Section: Figure 4 Photonic Emission Fromsupporting

confidence: 71%

HORSE SPECIES SYMPOSIUM: A novel approach to monitoring pathogen progression during uterine and placental infection in the mare using bioluminescence imaging technology and lux-modified bacteria1,2

Ryan¹,

Christiansen²,

Hopper³

et al. 2011

Journal of Animal Science

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Uterine and placental infections are the leading cause of abortion, stillbirth, and preterm delivery in the mare. Whereas uterine and placental infections in women have been studied extensively, a comprehensive examination of the pathogenic processes leading to this unsatisfactory pregnancy outcome in the mare has yet to be completed. Most information in the literature relating to late-term pregnancy loss in mares is based on retrospective studies of clinical cases submitted for necropsy. Here we report the development and application of a novel approach, whereby transgenically modified bacteria transformed with lux genes of Xenorhabdus luminescens or Photorhabdus luminescens origin and biophotonic imaging are utilized to better understand pathogen-induced preterm birth in late-term pregnant mares. This technology uses highly sensitive bioluminescence imaging camera systems to localize and monitor pathogen progression during tissue invasion by measuring the bioluminescent signatures emitted by the lux-modified pathogens. This method has an important advantage in that it allows for the potential tracking of pathogens in vivo in real time and over time, which was hitherto impossible. Although the application of this technology in domestic animals is in its infancy, investigators were successful in identifying the fetal lungs, sinuses, nares, urinary, and gastrointestinal systems as primary tissues for pathogen invasion after experimental infection of pregnant mares with lux-modified Escherichia coli. It is important that pathogens were not detected in other vital organs, such as the liver, brain, and cardiac system. Such precision in localizing sites of pathogen invasion provides potential application for this novel approach in the development of more targeted therapeutic interventions for pathogen-related diseases in the equine and other domestic species.

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Section: Figure 4 Photonic Emission Fromsupporting

confidence: 71%

HORSE SPECIES SYMPOSIUM: A novel approach to monitoring pathogen progression during uterine and placental infection in the mare using bioluminescence imaging technology and lux-modified bacteria1,2

Ryan¹,

Christiansen²,

Hopper³

et al. 2011

Journal of Animal Science

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“…Contrary to classical views, prenatal infection and inflammation appear to play a more important role in PVL than do hypoxia and acidosis [38,444,451]. Eighty percent of the offspring of rats inoculated with E. coli presented white matter lesions but only 6% had these lesions when IL-10 was administered concomitantly with E. coli [452]. The protective effect involves suppression of microglial activation and macrophage infiltration, decreased apoptosis, and restoration of oligodendrocyte function and myelinisation [453].…”

Section: Inflammation and Infant Outcomecontrasting

confidence: 51%

Preterm Birth: A Review

Schellenberg

2006

CWHR

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Preterm birth at less than 37 weeks gestation is a substantial burden to the community, representing a major source of infant death, severe handicap, and suffering for both victims and their families. Despite considerable research, little progress has been made in its prevention, partly because preterm birth is the endpoint of a silent multifactorial syndrome which begins long before labour starts. Infectious inflammation often plays a central role, but maternal susceptibility is probably also critical. Although progestogen treatment is preventive in some women with a prior history of preterm birth this will have little impact on the overall preterm birth rate unless effective treatment can be used in a much larger population of at risk women. An accurate screening test to identify such women is needed. The discovery of a screening test and of novel treatments requires a better understanding of the underlying biomolecular events. This paper gives an overview of the physiology and molecular biology of normal and abnormal pregnancy and parturition, the causes and consequences of preterm birth, and the difficulties of predicting and preventing preterm birth.

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“…In mouse astrocyte culture, IL-10 provides rapid onset suppression of IL-6 induction after IL-1␤ stimulation (32). In rats, maternal treatment with IL-10 prevented E. coli-related brain injury in the pups (34). Of particular interest for the present study, treatment with IL-10 within 24 h after LPS injection to pregnant rats prevented fetal growth retardation or death (37), whereas, in newborn mice, IL-10 attenuated both excitotoxic and IL-1␤-related neural injury (30).…”

Section: Discussionmentioning

confidence: 98%

Acute on chronic exposure to endotoxin in preterm fetal sheep

Mathai

Booth

Davidson

et al. 2013

American Journal of Physiology-Regulatory, Integrative and Comp

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Acute, high-dose exposure to endotoxin lipopolysaccharide (LPS) in preterm fetal sheep can trigger periventricular white matter lesions (PVL), in association with severe hypotension/hypoxemia and significant mortality. Intriguingly, however, chronic or repeated exposure to LPS can induce tachyphylaxis. We therefore tested the hypothesis that progressive, acute on chronic fetal infection would be associated with white matter injury with little fetal mortality. Chronically instrumented preterm (0.7 gestational age) fetal sheep were exposed to a continuous low-dose LPS infusion (100 ng over 24 h, followed by 250 ng/24 h for 96 h) or saline. Boluses of 1 μg LPS or saline were given at 48, 72, and 96 h; sheep were killed at day 10. Six of 11 fetal sheep exposed to saline infusion + LPS boluses died 4-7 h after the first bolus. In contrast, there was no fetal mortality after saline infusions alone (n = 9), low-dose LPS infusion + saline boluses (n = 5), or low-dose LPS + LPS boluses (n = 9). Low-dose LPS infusion + LPS boluses was associated with greater microglial induction than low-dose LPS + saline boluses but a similar area of periventricular white matter inflammation. One fetus developed severe focal white matter necrosis after LPS infusion + boluses. The acute cardiovascular compromise associated with high-dose, acute exposure to LPS is markedly attenuated by previous low-dose infusions, with limited apparent exacerbation of periventricular white matter injury compared with low-dose infusion alone.

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Maternal infection-induced white matter injury is reduced by treatment with interleukin-10

Cited by 12 publications

References 0 publications

HORSE SPECIES SYMPOSIUM: A novel approach to monitoring pathogen progression during uterine and placental infection in the mare using bioluminescence imaging technology and lux-modified bacteria1,2

HORSE SPECIES SYMPOSIUM: A novel approach to monitoring pathogen progression during uterine and placental infection in the mare using bioluminescence imaging technology and lux-modified bacteria1,2

Preterm Birth: A Review

Acute on chronic exposure to endotoxin in preterm fetal sheep

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