Maternal-infant antibiotic resistance genes transference: what do we know?

Samarra, Anna; Esteban-Torres, María; Cabrera‐Rubio, Raúl; Bernabeu, Manuel; Arboleya, Silvia; Gueimonde, Miguel; Collado, María Carmen

doi:10.1080/19490976.2023.2194797

Cited by 18 publications

(14 citation statements)

References 147 publications

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Section: Discussionmentioning

confidence: 99%

“…gentamicin and streptomycin) and macrolides (e.g. azithromycin and erythromycin) are widely used in the perinatal period 40 , therefore resistance is potentially acquired via antibiotic exposure. Milk and infant stool samples at one month were characterized by higher prevalence and diversity in resistance classes, compared to later time points.…”

Section: Discussionmentioning

confidence: 99%

“…The infant gut and the maternal milk microbiomes harbor a diverse landscape of antimicrobial resistance genes The gut is a reservoir of antimicrobial resistance, yet its composition and longitudinal variability remain poorly characterized in infants 35,36 . Even less is known about the antimicrobial resistance genes (ARGs), collectively known as the resistome 37 , present in human breast milk, and their transmission to the infant during lactation 21,[38][39][40] . To investigate the resistome in the maternal 41 , which leverages deep learning to predict antimicrobial resistance genes from metagenomic data.…”

Section: Strain Sharing Is More Common Among Unrelated Infants Born I...mentioning

confidence: 99%

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Assembly, stability, and dynamics of the infant gut microbiome are linked to bacterial strains and functions in mother’s milk

Allert,

Ferretti,

Johnson

et al. 2024

Preprint

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The establishment of the gut microbiome in early life is critical for healthy infant development. Although human milk is recommended as the sole source of nutrition for the human infant, little is known about how variation in milk composition, and especially the milk microbiome, shapes the microbial communities in the infant gut. Here, we quantified the similarity between the maternal milk and the infant gut microbiome using 507 metagenomic samples collected from 195 mother-infant pairs at one, three, and six months postpartum. We found that the microbial taxonomic overlap between milk and the infant gut was driven by bifidobacteria, in particular byB. longum. Infant stool samples dominated byB. longumalso showed higher temporal stability compared to samples dominated by other species. We identified two instances of strain sharing between maternal milk and the infant gut, one involving a commensal (B. longum) and one a pathobiont (K. pneumoniae). In addition, strain sharing between unrelated infants was higher among infants born at the same hospital compared to infants born in different hospitals, suggesting a potential role of the hospital environment in shaping the infant gut microbiome composition. The infant gut microbiome at one month compared to six months of age was enriched in metabolic pathways associated with de-novo molecule biosynthesis, suggesting that early colonisers might be more versatile and metabolically independent compared to later colonizers. Lastly, we found a significant overlap in antimicrobial resistance genes carriage between the mother's milk and their infant's gut microbiome. Taken together, our results suggest that the human milk microbiome has an important role in the assembly, composition, and stability of the infant gut microbiome.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Strain Sharing Is More Common Among Unrelated Infants Born I...mentioning

confidence: 99%

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Assembly, stability, and dynamics of the infant gut microbiome are linked to bacterial strains and functions in mother’s milk

Allert,

Ferretti,

Johnson

et al. 2024

Preprint

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“…Similarly, Samarra et al’s study [ 40 ] brings to light the critical issue of antibiotic resistance in the context of maternal and newborn health. The authors highlighted the risk of vertical transmission of antibiotic resistance from mothers to infants, particularly at birth, a pivotal moment for the infant’s exposure to potentially resistant microorganisms.…”

Section: Discussionmentioning

confidence: 99%

Impact of Genital Infections and Antibiotic Use on Incidence of Preterm Birth: A Retrospective Observational Study

Marti,

Bratosin,

Rosca

et al. 2024

Antibiotics

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This study investigates the complex interplay among genital infections, antibiotic usage, and preterm birth. This study aims to identify common genital pathogens associated with preterm births, assess the impact of various antibiotic treatments on pregnancy outcomes, and understand antibiotic resistance patterns among these pathogens. This study included 71 pregnant women who experienced preterm birth and 94 women with genital infections who delivered at term. Various maternal characteristics, medical history, signs and symptoms, gestational weight, gestational age, type of birth, vaginal pH, Nugent scores, and vaginal flora were analyzed. Antibiotic resistance patterns of isolated microorganisms were also examined. The prevalence of sexually transmitted diseases (STDs) and genital herpes was significantly higher in the preterm group. Preterm births were associated with fever, pelvic pain, vaginal spotting, and fatigue. Vaginal pH levels and Nugent scores were significantly higher in the preterm group, indicating disturbed vaginal flora. The presence of Extended-Spectrum Beta-Lactamases (ESBLs) was a particularly strong risk factor, increasing by more than four times the odds of preterm birth (OR = 4.45, p = 0.001). Vancomycin-Resistant Enterococci (VRE) presence was another critical factor, with a four-fold increase in the odds of preterm birth (OR = 4.01, p = 0.034). The overall presence of Multidrug-Resistant (MDR) organisms significantly increased the odds of preterm birth (OR = 3.73, p = 0.001). Specific pathogens like Chlamydia trachomatis (OR = 3.12, p = 0.020) and Mycoplasma hominis (OR = 3.64, p = 0.006) were also identified as significant risk factors. Ureaplasma urealyticum also showed a significantly higher risk of preterm birth (OR = 2.76, p = 0.009). This study highlights the importance of screening for and treating genital infections during pregnancy, especially STDs and genital herpes, as they can significantly increase the risk of preterm birth. Additionally, the presence of specific microorganisms and antibiotic resistance patterns plays an essential role in preterm birth risk. Early detection and targeted antibiotic treatment may help mitigate this risk and improve pregnancy outcomes.

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“…In neonates, the intestinal environment offers lower colonisation resistance, potentially facilitating the establishment of antibiotic-resistant populations. Factors correlated with an increased ARG prevalence include antibiotic use during childbirth and in the neonatal period [ 78 ]. Conversely, breastfeeding and the administration of probiotics to neonates are linked with a reduced presence of ARGs [ 79 ].…”

Section: Impact Of Maternal Microbiota On Foetal Immune System Develo...mentioning

confidence: 99%

Maternal-Foetal/Infant Interactions—Gut Microbiota and Immune Health

Adamczak,

Werblińska,

Jamka

et al. 2024

Biomedicines

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In recent years, the number of scientific publications on the role of intestinal microbiota in shaping human health, as well as the occurrence of intestinal dysbiosis in various disease entities, has increased dynamically. However, there is a gap in comprehensively understanding the factors influencing a child’s gut microbiota. This review discusses the establishment of gut microbiota and the immunological mechanisms regulating children’s microbiota, emphasising the importance of prioritising the development of appropriate gut microbiota in a child from the planning stages of pregnancy. The databases PubMed, Web of Sciences, Cochrane, Scopus and Google Scholar were searched to identify relevant articles. A child’s gut microbiota composition is influenced by numerous factors, such as diet during pregnancy, antibiotic therapy, the mother’s vaginal microbiota, delivery method, and, later, feeding method and environmental factors. During pregnancy, the foetus naturally acquires bacterial strains from the mother through the placenta, thereby shaping the newborn’s immune system. Inappropriate maternal vaginal microbiota may increase the risk of preterm birth. Formula-fed infants typically exhibit a more diverse microbiota than their breastfed counterparts. These factors, among others, shape the maturation of the child’s immune system, impacting the production of IgA antibodies that are central to cellular humoral immune defence. Further research should focus on identifying specific microbiota–immune system interactions influencing a child’s immune health and developing personalised treatment strategies for immune-related disorders.

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Maternal-infant antibiotic resistance genes transference: what do we know?

Cited by 18 publications

References 147 publications

Assembly, stability, and dynamics of the infant gut microbiome are linked to bacterial strains and functions in mother’s milk

Assembly, stability, and dynamics of the infant gut microbiome are linked to bacterial strains and functions in mother’s milk

Impact of Genital Infections and Antibiotic Use on Incidence of Preterm Birth: A Retrospective Observational Study

Maternal-Foetal/Infant Interactions—Gut Microbiota and Immune Health

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