Maternal immune activation induces autism-like behavior and reduces brain-derived neurotrophic factor levels in the hippocampus and offspring cortex of C57BL/6 mice

Dutra, Matheus Luchini; Dias, Paula; Freiberger, Viviane; Ventura, Luisa; Comim, Clarissa M.; Martins, Daniel Fernandes; Bobinski, Franciane

doi:10.1016/j.neulet.2022.136974

Cited by 10 publications

(5 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this regard Arutiunian et al, reported that reduced in grey matter volume of hippocampus is linked with the severity of ASD symptoms in children ( Arutiunian et al, 2023 ). Furthermore various studies have demonstrated role of neural and signaling alterations of the hippocampus in the pathophysiology of ASD ( Dutra et al, 2023 , Zohny et al, 2023 , Guo et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Anethole via increase in the gene expression of PI3K/AKT/mTOR mitigates the autistic-like behaviors induced by maternal separation stress in mice

Yadollahi-Farsani,

Vanani,

Lorigooini

et al. 2024

IBRO Neuroscience Reports

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Anethole via increase in the gene expression of PI3K/AKT/mTOR mitigates the autistic-like behaviors induced by maternal separation stress in mice

Yadollahi-Farsani,

Vanani,

Lorigooini

et al. 2024

IBRO Neuroscience Reports

View full text Add to dashboard Cite

“…Similarly, inducing seizure during pregnancy can prompt an increase in in ammatory factors in newborns [49]. These scenarios can lead to reduced BDNF levels, consequently impacting the behavioral functions [50,51].…”

Section: Discussionmentioning

confidence: 99%

Beneficial Impact of Aerobic Exercise During Pregnancy on Motor Coordination Deficits Induced by PTZ in Preadolescent Male Mice

Sabaghi,

Yousofvand

2024

Preprint

View full text Add to dashboard Cite

Objective Seizures during pregnancy have been linked to adverse outcomes for newborns and motor coordination (MC) defects in offspring. Physical activity has shown promise in reducing seizure severity and promoting positive outcomes for newborns. In this study, we investigated the impact of aerobic exercise during pregnancy on seizure activity in pregnant mice treated with pentylenetetrazole (PTZ) and the MC of preadolescence male mice.Methods Adult female ICR mice were divided into two groups and administered PTZ or saline for 30 days before mating. PTZ treatment continued throughout pregnancy for the experimental group, while the control group received saline. Active pregnant mice engaged in aerobic treadmill exercises from the first to the 20th day of pregnancy. MC in preadolescence male offspring was assessed using the rotarod test.Results Prenatal exposure to maternal seizures induced by PTZ resulted in MC deficiencies in preadolescence male offspring (P < 0.05). Aerobic exercise during pregnancy demonstrated beneficial effects on convulsive activity (P < 0.05) and was able to counteract the MC deficits caused by maternal seizures during pregnancy.Conclusion These findings suggest aerobic exercise during pregnancy may serve as a supplementary therapeutic approach to reduce convulsive activity and mitigate MC impairments in preadolescence male offspring.

show abstract

“…Another study has documented how maternal thyroid hormone deficiency affects neocortical cytoarchitecture and influences reelin expression in the offspring [ 41 , 42 ]. The role of maternal viral or bacterial infection in the first trimester of pregnancy in increasing the incidence of ASD has been largely documented in the literature [ 43 ]. Maternal mental distress [ 9 ] and malnutrition during pregnancy [ 16 ] have also been correlated with altered neurodevelopment in the offspring.…”

Section: Discussionmentioning

confidence: 99%

Maternal Epigenetic Dysregulation as a Possible Risk Factor for Neurodevelopmental Disorders

Lintas

Cassano

Azzarà

et al. 2023

Genes

View full text Add to dashboard Cite

Neurodevelopmental Disorders (NDs) are a heterogeneous group of disorders and are considered multifactorial diseases with both genetic and environmental components. Epigenetic dysregulation driven by adverse environmental factors has recently been documented in neurodevelopmental disorders as the possible etiological agent for their onset. However, most studies have focused on the epigenomes of the probands rather than on a possible epigenetic dysregulation arising in their mothers and influencing neurodevelopment during pregnancy. The aim of this research was to analyze the methylation profile of four well-known genes involved in neurodevelopment (BDNF, RELN, MTHFR and HTR1A) in the mothers of forty-five age-matched AS (Asperger Syndrome), ADHD (Attention Deficit Hyperactivity Disorder) and typically developing children. We found a significant increase of methylation at the promoter of the RELN and HTR1A genes in AS mothers compared to ADHD and healthy control mothers. For the MTHFR gene, promoter methylation was significantly higher in AS mothers compared to healthy control mothers only. The observed dysregulation in AS mothers could potentially contribute to the affected condition in their children deserving further investigation.

show abstract

Maternal immune activation induces autism-like behavior and reduces brain-derived neurotrophic factor levels in the hippocampus and offspring cortex of C57BL/6 mice

Cited by 10 publications

References 61 publications

Anethole via increase in the gene expression of PI3K/AKT/mTOR mitigates the autistic-like behaviors induced by maternal separation stress in mice

Anethole via increase in the gene expression of PI3K/AKT/mTOR mitigates the autistic-like behaviors induced by maternal separation stress in mice

Beneficial Impact of Aerobic Exercise During Pregnancy on Motor Coordination Deficits Induced by PTZ in Preadolescent Male Mice

Maternal Epigenetic Dysregulation as a Possible Risk Factor for Neurodevelopmental Disorders

Contact Info

Product

Resources

About