Maternal IgA2 Recognizes Similar Fractions of Colostrum and Fecal Neonatal Microbiota

Sánchez‐Salguero, Erick; Corona-Cervantes, Karina; Guzmán-Aquino, Héctor; Borbolla-Cruz, María Fernanda de la; Contreras-Vargas, Víctor; Piña-Escobedo, Alberto; García‐Mena, Jaime; Santos‐Argumedo, Leopoldo

doi:10.3389/fimmu.2021.712130

Cited by 3 publications

(2 citation statements)

References 71 publications

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“…15 La leche materna no es solo una fuente de nutrimentos para el bebé; también es un vehículo para una amplia variedad de componentes bioactivos, incluidos los microorganismos, que contribuyen a la composición de la microbiota de la leche materna, incluidos los prebióticos, probióticos, inmunoglobulinas y otros factores que promueven el crecimiento y la colonización de bacterias beneficiosas en el intestino del bebé. [16][17][18][19][20][21][22] La composición de la microbiota de la leche materna puede variar entre mujeres y también a lo largo del tiempo. Se han detectado diferentes géneros bacterianos en la leche materna, como: Lactobacillus, Bifidobacterium, Streptococcus, Staphylococcus, y otros.…”

Section: La Microbiota Humanaunclassified

Establecimiento del microbiota intestinal del recién nacido durante la lactancia materna

Sanchez Salguero

2024

Acta Pediatr Mex

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El establecimiento de la microbiota intestinal del recién nacido es un proceso crucial que ocurre durante el nacimiento y la lactancia, jugando un papel fundamental en el desarrollo del sistema inmunológico y la salud del bebé a lo largo de su vida. En esta pequeña revisión exponemos los principales componentes de la microbiota neonatal y damos un panorama general de su efecto en el desarrollo de la respuesta inmunológica en el intestino del recién nacido.

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Section: La Microbiota Humanaunclassified

Establecimiento del microbiota intestinal del recién nacido durante la lactancia materna

Sanchez Salguero

2024

Acta Pediatr Mex

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“…It likely continues a protective role until breastfeeding is established on the second or third day of life ( Klein et al, 2017 ). Maternal factors in colostrum and early milk directly support the early establishment of a healthy microbiota ( Sánchez-Salguero et al, 2021 ).…”

Section: New Perspectives On Kmcmentioning

confidence: 99%

New policies on skin-to-skin contact warrant an oxytocin-based perspective on perinatal health care

Bergman

2024

Front. Psychol.

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BackgroundIn 2023, the World Health Organization (WHO) published a Global Position Paper on Kangaroo Mother Care (KMC), which is applicable to all countries worldwide: from the moment of birth, every “small and sick” newborn should remain with mother in immediate and continuous skin-to-skin contact (SSC), receiving all required clinical care in that place. This was prompted by the startling results of a randomized controlled trial published in 2021: in which 1,609 infants receiving immediate SSC were compared with 1,602 controls that were separated from their mothers but otherwise received identical conventional state-of-the-art care. The intervention infants showed a 25% reduction in mortality after 28 days.New perspectivesThe new WHO guidelines are a significant change from earlier guidance and common clinical practice. The author presents that separating mothers and babies is assumed to be “normal” (a paradigm) but actually puts newborns at increased risk for morbidity and mortality. The author presents arguments and ethical perspectives for a new perspective on what is “normal,” keeping newborns with their mothers is the infant’s physiological expectation and critical requirement for healthy development. The author reviews the scientific rationale for changing the paradigm, based on synchronous interactions of oxytocin on both mother and infant. This follows a critique of the new policies that highlights the role of immediate SSC.Actionable recommendationsThis critique strengthens the case for implementing the WHO guidelines on KMC for small and sick babies. System changes will be necessary in both obstetric and neonatal settings to ensure seamless perinatal care. Based on the role of oxytocin, the author identifies that many current routine care practices may actually contribute to stress and increased vulnerability to the newborn. WHO has actionable recommendations about family involvement and presence in newborn intensive care units.DiscussionThe concepts of resilience and vulnerability have specific definitions well known in perinatal care: the key outcome of care should be resilience rather than merely the absence of vulnerability. Newborns in all settings and contexts need us to re-evaluate our paradigms and adopt and implement the new WHO guidelines on KMC in perinatal care.

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IgA2 immune complexes selectively promote inflammation by human CD103+ dendritic cells

et al. 2023

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While immunoglobulin A (IgA) is well known for its neutralizing and anti-inflammatory function, it is becoming increasingly clear that IgA can also induce human inflammatory responses by various different immune cells. Yet, little is known about the relative role of induction of inflammation by the two IgA subclasses i.e. IgA1, most prominent subclass in circulation, and IgA2, most prominent subclass in the lower intestine. Here, we set out to study the inflammatory function of IgA subclasses on different human myeloid immune cell subsets, including monocytes, and in vitro differentiated macrophages and intestinal CD103+ dendritic cells (DCs). While individual stimulation with IgA immune complexes only induced limited inflammatory responses by human immune cells, both IgA subclasses strongly amplified pro-inflammatory cytokine production upon co-stimulation with Toll-like receptor (TLR) ligands such as Pam3CSK4, PGN, and LPS. Strikingly, while IgA1 induced slightly higher or similar levels of pro-inflammatory cytokines by monocytes and macrophages, respectively, IgA2 induced substantially more inflammation than IgA1 by CD103+ DCs. In addition to pro-inflammatory cytokine proteins, IgA2 also induced higher mRNA expression levels, indicating that amplification of pro-inflammatory cytokine production is at least partially regulated at the level of gene transcription. Interestingly, cytokine amplification by IgA1 was almost completely dependent on Fc alpha receptor I (FcαRI), whilst blocking this receptor only partially reduced cytokine induction by IgA2. In addition, IgA2-induced amplification of pro-inflammatory cytokines was less dependent on signaling through the kinases Syk, PI3K, and TBK1/IKKϵ. Combined, these findings indicate that IgA2 immune complexes, which are most abundantly expressed in the lower intestine, particularly promote inflammation by human CD103+ intestinal DCs. This may serve an important physiological function upon infection, by enabling inflammatory responses by this otherwise tolerogenic DC subset. Since various inflammatory disorders are characterized by disturbances in IgA subclass balance, this may also play a role in the induction or exacerbation of chronic intestinal inflammation.

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Maternal IgA2 Recognizes Similar Fractions of Colostrum and Fecal Neonatal Microbiota

Cited by 3 publications

References 71 publications

Establecimiento del microbiota intestinal del recién nacido durante la lactancia materna

Establecimiento del microbiota intestinal del recién nacido durante la lactancia materna

New policies on skin-to-skin contact warrant an oxytocin-based perspective on perinatal health care

IgA2 immune complexes selectively promote inflammation by human CD103+ dendritic cells

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