Maternal Hyperthermia as a Possible Cause of Anencephaly

Miller, P. L.; Smith, Dale E.; Shepard, T. H.

doi:10.1016/s0140-6736(78)90549-4

Cited by 184 publications

(55 citation statements)

References 5 publications

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“…Maternal hyperthermia during pregnancy has been implicated in human birth defects, with particularly damaging effects on the central nervous system (CNS) of the embryo [1][2][3][4][5][6][7]. In experimental animals, neural tube defects, microcephaly, and other defects have been produced in various animal spe cies following prenatal heat stress [8].…”

Section: Introductionmentioning

confidence: 99%

Effects of Prenatal Heat Stress on Postnatal Growth, Behavior and Learning Capacity in Mice

Shiota

Kayamura²

1989

Neonatology

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Pregnant ICR mice were immersed in water at 42 or 43 °C for 10 min once or twice daily on days 12 through 15 of gestation and the postnatal development of their offspring was observed. Postnatal weight gain of the offspring and their brain weight at 11 weeks of age were smaller than the values for control animals. As compared with controls, prenatally heated mice were less active in an open field and learned slower in a water-filled multiple T-maze and in a shuttle box. Thus, prenatal brief hyperthermia in mice was shown to suppress the body and brain growth during the postnatal period and adversely affect their emotionality and learning capacity.

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Section: Introductionmentioning

confidence: 99%

Effects of Prenatal Heat Stress on Postnatal Growth, Behavior and Learning Capacity in Mice

Shiota

Kayamura²

1989

Neonatology

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“…Smith and his co-workers retrospectively evaluated the effects of hyperthermia in hu man pregnancy and showed that maternal fever over 38.9 °C was often associated with malformations of the central nervous system including anencephaly [Miller et al, 1978], encephalocele [Fisher and Smith, 1981], me ningomyelocele [Chance and Smith, 1978] and less-specific midfacial dysmorphogenesis and CNS dysfunction [Pleet et al, 1981]. A significant increase in fever episodes was mentioned in mothers who delivered infants with spina bifida [Layde et al, 1980] and in mothers of therapeutically aborted embryos with exencephaly which is an embryonic forerunner of anencephaly [Shiota, 1982].…”

Section: Introductionmentioning

confidence: 99%

Induction of Neural Tube Defects and Skeletal Malformations in Mice following Brief Hyperthermia in utero

Shiota¹

1988

Neonatology

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Hyperthermia was induced in ICR mice on day 8.5 of gestation by immersing them in hot water. Control mice were immersed in water at 38°C for 15 min. In dams exposed to 42°C for 12.5–15 min or to 43°C for 7.5–10 min, externally malformed fetuses increased significantly and in a dose-related manner. Anterior neural tube defects (exencephaly, anencephaly, encephalocele, and cranial neural tube defect with facial cleft) were induced most frequently. Embryonic and fetal death and skeletal malformations also increased following heat stress. At intervals after heat exposure, sections of embryonic prosencephalon were prepared for light microscopy. At 2 h after heat stress, mitotic figures disappeared almost completely in embryonic tissues. Mitotic activity was inhibited for at least 3 h. At 6 h, there was a burst of new mitotic activity. Some damaged cells became pyknotic and abnormal cells were encountered in the neuroepithelial tissue after 3–12 h. Thus, neural tube defects in mouse embryos following maternal hyperthermia may result from a temporary cessation of cell proliferation and partial necrosis of the embryonic neuroepithelium.

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“…It is also possible that exposure to febrile illness or high temperatures in the early stages of pregnancy may induce fetal deformities. For example, seven out of sixty-three mothers who gave birth to have used a high temperature sauna or suffered a anencephalic infants were found to febrile illness with a temperature over 38.9 °C between 23 to 26 days post-gestation, which is the period of anterior neural-groove closure 113) . Additionally, mothers who gave birth to deformed infants were reported to have suffered from influenza during the first trimester of pregnancy 114) .…”

Section: (3) Hsps and Their Usefulness In Physical Therapymentioning

confidence: 99%

A Review of Signal Transduction in Mechanisms of Smooth Muscle Contraction and Its Relevance for Specialized Physical Therapy

Kim

Lee

et al. 2013

J Phys Ther Sci

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Abstract.[Purpose] An understanding of smooth muscle contraction is important in the study of specialized physical therapy. In this paper, we summarize the contraction mechanisms of smooth muscle and suggest their applications in physical therapy. [Method] This review focuses on the signaling pathways that control smooth muscle contraction and its mechanisms. We include results reported by our laboratory in a wider literature review. [Results] Our results and the literature show that various mechanisms of smooth muscle contraction exist. [Conclusions] In this review article, we carefully discuss the signal transduction in smooth muscle contraction based on our studies and with reference to physical therapy.

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Maternal Hyperthermia as a Possible Cause of Anencephaly

Cited by 184 publications

References 5 publications

Effects of Prenatal Heat Stress on Postnatal Growth, Behavior and Learning Capacity in Mice

Effects of Prenatal Heat Stress on Postnatal Growth, Behavior and Learning Capacity in Mice

Induction of Neural Tube Defects and Skeletal Malformations in Mice following Brief Hyperthermia in utero

A Review of Signal Transduction in Mechanisms of Smooth Muscle Contraction and Its Relevance for Specialized Physical Therapy

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