Maternal hypertensive disorders and subtypes of hypospadias: A Dutch case‐control study

Jamaladin, Hussein; Rooij, Iris A. L. M. van; Zanden, Loes F M van der; Gelder, Marleen M.H.J. van

doi:10.1111/ppe.12683

Cited by 4 publications

(1 citation statement)

References 33 publications

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“…Sherrif et al observed notable positive associations between hypertension and hypospadias (OR 1.68; 95% CI 1.46–1.93) (Sheriff et al, 2019). However, a study by Jamaladin et al found no associations between maternal hypertensive disorders in general, chronic hypertension, or gestational hypertension and hypospadias or its subtypes (Jamaladin et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Potential risk factors for hypospadias and negative correlation with DICER1 (rs3742330) A>G variant in Algerian population: A case‐control study

Rania,

Djalila,

Brahim

et al. 2024

Birth Defects Research

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BackgroundHypospadias continues to be a prevalent congenital anomaly affecting the male external genitalia, characterized by an unclear origin and complex treatment approaches. This study aimed to investigate the risk factors associated with hypospadias and explore its genetic link with the DICER1 rs3742330 variant.MethodsThe study involved two groups: 105 male children with hypospadias and 111 healthy male children as matched controls. Detailed history and physical examinations were conducted for all patients and controls. PCR‐restriction fragment length polymorphism was utilized to identify the DICER1 rs3742330 variant, analyzing genotype distribution and allele frequency. Logistic regression analysis estimated the risk factors for hypospadias.ResultsThe mean age in the hypospadias group was 4.56 ± 2.50 years. The most prevalent type of hypospadias observed was the anterior type in 60 children (57.14%). Intrauterine growth restriction, advanced maternal age, and gestational hypertension were identified as significant risk factors for hypospadias (p = .011, p = .016, and p = .041, respectively). Regarding the genetic study, no significant difference was found in both genotype and allele frequencies of the DICER1 rs3742330 variant between case and control groups.ConclusionsThe rs3742330 variant in the DICER1 gene showed no association with hypospadias cases in the Algerian population. However, multivariate logistic regression analysis identified preterm birth, low birth weight, intrauterine growth restriction, advanced maternal age, gestational diabetes, and rural residence as the most significant independent predictors for hypospadias.

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Section: Discussionmentioning

confidence: 99%