Maternal homocysteine and related B vitamins as risk factors for low birthweight

Hogeveen, Marije; Blom, Henk J.; Heijden, Elisabeth H. van der; Semmekrot, B.A.; Sporken, Jan; Ueland, Per Magne; Heijer, Martin den

doi:10.1016/j.ajog.2010.01.045

Cited by 34 publications

(42 citation statements)

References 44 publications

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“…Our findings that moderate folate levels in early pregnancy are associated with higher birth weight regardless of race/ethnicity are consistent with previous studies, [14][15][16][17][18][19][20][21][22][23][24]50 although an equally large number of studies from Europe, Asia and the US [25][26][27][28][29][30][31] have not confirmed these associations. Reasons for discordant findings are unclear.…”

Section: Discussionsupporting

confidence: 88%

“…13 In humans, evidence of associations between maternal folate concentrations and fetal growth is conflicting, as high levels have been linked to both low and high birth weight, [14][15][16][17][18][19][20][21][22][23][24] while other studies found no associations. [25][26][27][28][29][30][31] Extremes of the birth weight distribution have been associated with a wide range of childhood and adultonset chronic diseases and conditions including obesity, impaired glucose tolerance, type 2 diabetes, coronary artery disease, congestive heart failure and some cancers. [32][33][34][35][36] Periconceptional and perinatal exposure to FA supplements has also been linked to wheezing in mice 37 and humans, 38 as well as childhood asthma.…”

Section: Introductionmentioning

confidence: 99%

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Erythrocyte folate concentrations, CpG methylation at genomically imprinted domains, and birth weight in a multiethnic newborn cohort

et al. 2014

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Erythrocyte folate concentrations, CpG methylation at genomically imprinted domains, and birth weight in a multiethnic newborn cohort

et al. 2014

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“…Recently, a meta-analysis was done included eighteen studies observed no linear association between maternal B12 levels in pregnancy and birth weight, but B12 deficiency (<148 pmol/L) was associated with a higher risk of LBW in newborns (adjusted risk ratio = 1.15, 95% confidence interval (CI): 1.01, 1.31) [39]. However, several studies did not detect any association between maternal vitamin B12 levels and fetal growth restriction [3] [42]. Recently a systematic review and meta analysis done by Sukumar et al [7] they reviewed 57 reviews and 23 articles, showed non significantly lower maternal vitamin B12 concentrations in LBW than in ABW infants but higher odds of LBW with lower vitamin B12 values (adjusted OR: 1.70; 95% CI: 1.16, 2.50), and concluded that there was no significant effect of low maternal vitamin B12 level and LBW.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Third Trimester Maternal Serum Vitamin B12 and Folate Status on Fetal Birth Weight. Is Maternal Serum Homocysteine a Predictor of Low Birth Weight Infants?

Youssry¹,

Radwan²,

Gebreel³

et al. 2017

OJOG

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Objective: The aim of this study is to evaluate vitamin B12, folate, and homocysteine status in pregnant women in the third trimester of pregnancy and their relationship to fetal birth weight and their correlation to corresponding neonatal cord blood levels, and in addition, to evaluate the possibility of maternal serum homocysteine level as a predictor of low birth weight infants. Subjects and Methods: In this cross-sectional study, a total of two hundred pregnant women in third trimester (≥28 weeks) were recruited. After a detailed obstetrical and medical history, and clinical assessment, participants were subdivided into two groups: Group (A)-pregnant women who delivered average birth weight (ABW) infants and Group (B) for those who delivered low birth weight (LBW) infants between completed 37 and 42 weeks. Results: Vitamin B12 deficiency was observed in 24.1% of the total cohort. The mean vitamin B12 level was significantly lower in group (B) compared to group (A) (195.2 ± 38.9 vs. 225.9 ± 66.59 respectively P = 0.008). The mean level of homocysteine for women in group (B) was significantly higher than those determined from women in group (A) (9.10 ± 5.9 vs. 7.6 ± 3.83 respectively, P = 0.042). On the other hand, the mean folate levels showed statistically insignificant differences between both groups. The mean cord vitamin B12 level was significantly lower in LBW infants in comparison to ABW infants (277 ± 61.93 vs. 312.03 ± 81.87 respectively, P = 0.015), while the mean level of cord homocysteine for LBW infants was significantly higher than those levels determined from ABW infants (7.9 ± 3.79 vs. 6.6 ± 2.09 respec- deficiency could be significant risk for LBW infants. Hyperhomocysteinemia has been shown to be a predictor for adverse pregnancy outcomes particularly LBW.

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“…Patients were recruited as described before (27). In summary, patients were included in our study when visiting the outpatient clinic and/ or the delivery ward of the department of Obstetrics and Gynecology at the Canisius Wilhelmina Hospital in Nijmegen, the Netherlands.…”

Section: Participantsmentioning

confidence: 99%

Umbilical choline and related methylamines betaine and dimethylglycine in relation to birth weight

et al. 2013

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Background: Low birth weight (LBW) is associated with increased morbidity and mortality for the newborn and risk of chronic disease in adulthood. Choline plays an essential role in the integrity of cell membranes, methylation reactions, and memory development. We examined whether choline, betaine, and dimethylglycine (DMG) concentrations were associated with LBW in Dutch women. Methods: Blood was sampled from umbilical cords (UCs) at delivery in singleton pregnancies (n = 1,126). Maternal blood was sampled at 30-34 wk of gestational age (GA) (n = 366). We calculated birth weights standardized for GA and defined LBW as standardized birth weight ≤2,500 g. results: Maternal concentrations were lower as compared with UC concentrations and were not associated with birth weight. UC choline and betaine were inversely associated with birth weight (β = −60 (−89, −31) and β = −65 (−94, −36), respectively), whereas UC DMG was positively associated with birth weight (β = 35 (6.1, 63)). Odds ratios for LBW were 4.12 (1.15, 14.78), 5.68 (1.24, 25.91), and 0.48 (0.09, 2.65) for the highest UC choline, betaine, and DMG quartiles, respectively, as compared with the lowest quartiles. conclusion: We observed an increased risk of LBW with increased umbilical choline and betaine in venous UC blood. These results might reflect a change in choline consumption or metabolism or a disturbed placental function. l ow birth weight (LBW) poses the newborn an increased risk of morbidity and mortality (1). LBW also relates to an increased risk of chronic disease in adulthood, e.g., hypertension, coronary heart disease, stroke, and diabetes (2), underlining the importance of revealing possible and moreover treatable risk factors for LBW.Choline is an essential nutrient and is involved in several metabolic processes including lipid metabolism, methylation reactions, and synthesis of acetylcholine. It also plays a role in the structural integrity and signaling functions of cell membranes, brain development, and neurotransmission (Figure 1) (3,4).Pregnancy places a heavy burden on maternal choline stores, and choline is critical for the rapidly growing fetus (5,6).In utero, the fetus lives in a high-choline environment because of a system actively transporting choline against a concentration gradient across the placenta to the fetus (7,8). Variation in maternal choline status could possibly influence fetal outcome through disturbances in cell membrane synthesis, increase in homocysteine concentrations, and/or perturbation of methylation reactions and changes in acetylcholine production. Choline also influences stem cell proliferation, apoptosis in the brain, and the developing hippocampus (memory center) in rodents (9). Maternal choline supplementation in rats during critical periods in pregnancy causes lifelong changes in brain structure (10). In addition, perinatal choline supplementation attenuates behavioral alterations associated with fetal or neonatal alcohol exposure in rats (11).Clinically, low maternal choline concentrations or intake rel...

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Maternal homocysteine and related B vitamins as risk factors for low birthweight

Cited by 34 publications

References 44 publications

Erythrocyte folate concentrations, CpG methylation at genomically imprinted domains, and birth weight in a multiethnic newborn cohort

Erythrocyte folate concentrations, CpG methylation at genomically imprinted domains, and birth weight in a multiethnic newborn cohort

The Impact of Third Trimester Maternal Serum Vitamin B12 and Folate Status on Fetal Birth Weight. Is Maternal Serum Homocysteine a Predictor of Low Birth Weight Infants?

Umbilical choline and related methylamines betaine and dimethylglycine in relation to birth weight

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