Maternal HLA-G*01:01:01:04 protects from anti-HLA-class II immunization in pregnant women

Slimane, Mohamed Naceur; Picard, Christophe; Chiaroni, Jacques; Loundou, Anderson; Paganini, Julien; Tiberghien, Pierre; Rebibou, Jean-Michel; Cristofaro, Julie Di

doi:10.1016/j.humimm.2018.11.003

Cited by 2 publications

(2 citation statements)

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“…No HLA Ib genetic polymorphism or IgG4 expression was significantly associated with anti-HLA II immunization, suggesting that anti-HLA I and anti-HLA II immunization may be driven by different factors, as previously suggested ( 31 ). We could not investigate previous published data on the protective role of H03-UTR6-HLA-G*01:01:01:04 on anti-HLA II immunization during pregnancy ( 31 ) as this haplotype was not observed in the cohort under study.…”

Section: Discussionsupporting

confidence: 70%

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Maternal HLA Ib Polymorphisms in Pregnancy Allo-Immunization

Persson

Picard

Marin³

et al. 2021

Front. Immunol.

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During pregnancy the formation of alloreactive anti-human leukocyte antigen (HLA) antibodies are a major cause of acute rejection in organ transplantation and of adverse effects in blood transfusion. The purpose of the study was to identify maternal HLA class Ib genetic factors associated with anti-HLA allo-immunization in pregnancy and the degree of tolerance estimated by IgG4 expression. In total, 86 primiparous women with singleton pregnancies were included in the study. Maternal blood samples and umbilical cord samples were collected at delivery. Clinical data were obtained. Maternal blood serum was screened for HLA class I and II antibodies, identification of Donor Specific Antibody (DSA), activation of complement measured by C1q and IgG4 concentrations. Mothers were genotyped for HLA class Ib (HLA-E, -F and -G). Anti-HLA class I and II antibodies were identified in 24% of the women. The maternal HLA-E*01:06 allele was significantly associated with a higher fraction of anti-HLA I immunization (20.0% vs. 4.8%, p = 0.048). The maternal HLA-G 3’-untranslated region UTR4-HLA-G*01:01:01:05 haplotype and the HLA-F*01:03:01 allele were significantly associated with a low anti-HLA I C1q activation (16.7% vs. 57.1%, p = 0.028; 16.7% vs. 50.0%, p = 0.046; respectively). Both HLA‑G and HLA-F*01:03:01 showed significantly higher levels of IgG4 compared with the other haplotypes. The results support an association of certain HLA class Ib alleles with allo-immunization during pregnancy. Further studies are needed to elucidate the roles of HLA-E*01:06, HLA-F*01:03 and HLA‑G UTR4 in reducing the risk for allo-immunization.

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Section: Discussionsupporting

confidence: 70%

“…Different HLA-G alleles have been associated both to the HLA-G expression level (22)(23)(24)(25)(26) and a better tolerance in pregnancy (27)(28)(29)(30). A previous study on immunization in pregnancy suggested that the HLA-G*01:01:01:04 allele is protective against anti-HLA class II immunization (31).…”

Section: Introductionmentioning

confidence: 99%

Maternal HLA Ib Polymorphisms in Pregnancy Allo-Immunization

Persson

Picard

Marin³

et al. 2021

Front. Immunol.

Self Cite

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Immunological harmony: the dynamic influence of cellular and humoral immunity on pregnancy success

Pandey

2024

Discov. Immun.

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This study is a crucial step in understanding the dynamics of the maternal immune response directed at paternal human leukocyte antigen (HLA) molecules. HLA molecules are proteins on cell surfaces that play a critical role in immune system regulation. Our findings focus on the pivotal role of maternal antibodies targeting fetal HLA molecules in inhibiting antigen-induced activation of uterine immune cells, which is essential for successful pregnancies. Antibodies are proteins produced by the immune system that recognize and neutralize foreign substances. The primary focus is to unravel maternal anti-fetal rejection by drawing parallels to transplant rejection and emphasizing the role of allorecognition—the process by which an individual’s immune system recognizes and responds to antigens from another individual of the same species—in both cellular (involving immune cells) and humoral (involving antibodies) refusal. Although exploring anti-HLA antibodies in preventing fetal loss in patients with recurrent spontaneous abortion is captivating, there are still significant knowledge gaps that need to be addressed. Further studies are imperative to reveal the precise mechanism by which these antibodies generate and prevent maternal immune responses, critical determinants of pregnancy outcomes. It is vital to investigate the specificity of these antibodies and whether they exclusively target specific HLA molecules on trophoblasts (cells forming the outer layer of a blastocyst, providing nutrients to the embryo). This review paper not only offers insights into the development of these protective antibodies in pregnancy but also lays the foundation for future research on therapeutic implications, particularly in cases of recurrent spontaneous abortion.

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Maternal HLA-G*01:01:01:04 protects from anti-HLA-class II immunization in pregnant women

Cited by 2 publications

References 31 publications

Maternal HLA Ib Polymorphisms in Pregnancy Allo-Immunization

Maternal HLA Ib Polymorphisms in Pregnancy Allo-Immunization

Immunological harmony: the dynamic influence of cellular and humoral immunity on pregnancy success

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