Maternal high salt-diet increases offspring's blood pressure with dysfunction of NO/PKGI signaling pathway in heart tissue

Huang, Minshan; Li, Xiuying; Ren, Lihua; Huang, Lin; Pan, Jiahong; Yao, Jinlin; Li, Du; Chen, Dunjin; Chen, Jingsi

doi:10.1016/j.gocm.2022.03.001

Cited by 3 publications

(2 citation statements)

References 39 publications

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“…42 Conversely, the Ca 2+ level in ISF was reduced by HSD and completely recovered by subsequent LSD. This is because hypernatremia causes hypertension 43 and excretion of excess sodium ions through the kidney, which in turn causes the loss of Ca 2+ ions. 44 Previous studies in humans have shown that every 0.6 mM increase in ISF K + reduces pH by ∼0.1 unit.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Microneedle-Coupled Epidermal Sensors for In-Situ-Multiplexed Ion Detection in Interstitial Fluids

Zhu

Tan

Zheng

et al. 2023

ACS Appl. Mater. Interfaces

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Maintaining the concentrations of various ions in body fluids is critical to all living organisms. In this contribution, we designed a flexible microneedle patch coupled electrode array (MNP-EA) for the in situ multiplexed detection of ion species (Na+, K+, Ca2+, and H+) in tissue interstitial fluid (ISF). The microneedles (MNs) are mechanically robust for skin or cuticle penetration (0.21 N/needle) and highly swellable to quickly extract sufficient ISF onto the ion-selective electrochemical electrodes (∼6.87 μL/needle in 5 min). The potentiometric sensor can simultaneously detect these ion species with nearly Nernstian response in the ranges wider enough for diagnosis purposes (Na+: 0.75–200 mM, K+: 1–128 mM, Ca2+: 0.25–4.25 mM, pH: 5.5–8.5). The in vivo experiments on mice, humans, and plants demonstrate the feasibility of MNP-EA for timely and convenient diagnosis of ion imbalances with minimal invasiveness. This transdermal sensing platform shall be instrumental to home-based diagnosis and health monitoring of chronic diseases and is also promising for smart agriculture and the study of plant biology.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Microneedle-Coupled Epidermal Sensors for In-Situ-Multiplexed Ion Detection in Interstitial Fluids

Zhu

Tan

Zheng

et al. 2023

ACS Appl. Mater. Interfaces

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“…In experimental studies, high salt intake affects health negatively and increases body weight, blood insulin and glucose levels namely metabolic syndrome in rats (8). Excessive salt intake during the fetal period may adversely affect the fetus (9). High salt intake during pregnancy and lactation may also exacerbate the detrimental impact of the Western diet on the offspring (2).…”

Section: Introductionmentioning

confidence: 99%

The Investigation of The Metabolic Effect of High Salt or Western Diet During Pregnancy and Lactation on Rat Dams and Postnatal Offspring Rats

Öztürk,

Yabancı Ayhan

2024

Clinical and Experimental Health Sciences

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Objective: This study investigated the metabolic effect of maternal high-salt and western low-protein diets during pregnancy and lactation periods on rat dams and adult offspring. Methods: Female rat dams were divided into four groups and fed with a 1% high salt diet, a Western low-protein diet (high fat and sugar and low protein), or a 1% high salt/western low-protein combined diet (WS) during pregnancy and lactation. Afterward, 95 female and male offspring were divided into groups and fed with those diets until 18 weeks of age. The mothers’ and offspring rats' body weights and chow intake were recorded periodically. At 18 weeks of age, blood samples were collected from the offspring. Their blood lipid profiles, leptin, and insulin levels were analyzed. Results: Rat dams had similar weight changes during pregnancy and lactation. Rats exposed to the Western low-protein and WS diet during pregnancy, lactation, and/or postweaning had lower body weights than the control group. Male adult offspring from control dams and fed high salt were heavier and had higher LDL cholesterol than controls. However, rats from high salt dams and fed a high salt diet had lower body weights than the control group. Plasma insulin and leptin of male rats were not significantly different. Female offspring fed Western low-protein and WS diet in the fetal period or in early childhood had significantly low insulin. However, female rats exposed to Western low-protein and WS diets during pregnancy, lactation, and postweaning had similar insulin to control rats. Conclusion: Maintaining the maternal diet after lactation prevents the detrimental effect of a low-protein diet on insulin levels. Anti-obesity mechanism may develop in offspring exposed to a high salt diet during the fetal period against salt intake in later life.

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Risk factors for hypertension in pregnant women in Indonesia: A cross-sectional study

Oktarina,

Nantabah,

Nyoman

et al. 2024

Asian Pacific Journal of Tropical Medicine

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Objective: To determine the risk factors for hypertension in pregnant women, which is a significant cause of maternal and newborn morbidity and mortality in Indonesia. Methods: This was a cross-sectional study used secondary data from the 2018 Indonesian Basic Health Research. Pregnant women aged 15-54 years in the second and third trimesters were eligible. The history of hypertension in pregnant women was the dependent variable. The independent variables consisted of the demographic characteristics of pregnant women including pregnancy age, gestational age, education, occupation, place of residence, and region of residence. This study used multivariate logistic regression to determine the risk factors for hypertension in pregnant women in Indonesia. Results: Among 6479 respondents included in this study, 11 (7.0%) had a history of diabetes mellitus (DM) and hypertension compared to pregnant women who did not have a history of DM (0.1%). The dominant risk factors for hypertension in pregnant women in Indonesia include maternal age above 35 years (OR 3.67, 95% CI 2.54-5.32), third-trimester pregnancy (OR 2.40, 95% CI 1.72-3.35), primigravida (OR 1.78, 95% CI 1.19-2.68), excessive consumption of salty foods (OR 1.44, 95% CI 1.03-2.03), and diabetes mellitus (OR 10.20, 95% CI 3.04-32.23). Conclusions: Great efforts must be made to increase public awareness about the dangers of hypertension in pregnant women through early diagnosis and treatment, education on sodium intake, and appropriate care for pregnant women with DM.

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Maternal high salt-diet increases offspring's blood pressure with dysfunction of NO/PKGI signaling pathway in heart tissue

Cited by 3 publications

References 39 publications

Microneedle-Coupled Epidermal Sensors for In-Situ-Multiplexed Ion Detection in Interstitial Fluids

Microneedle-Coupled Epidermal Sensors for In-Situ-Multiplexed Ion Detection in Interstitial Fluids

The Investigation of The Metabolic Effect of High Salt or Western Diet During Pregnancy and Lactation on Rat Dams and Postnatal Offspring Rats

Risk factors for hypertension in pregnant women in Indonesia: A cross-sectional study

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