Maternal high‐salt diet during pregnancy impairs synaptic plasticity and memory in offspring

Abstract

Sodium chloride is a major source of salt in human nutrition. It is well-known that long-term high-salt diet (HSD) was associated with the development of hypertension and cardiovascular disease, especially when sodium intake exceeds 5 g/day. 1 There is an emerging evidence that the consumptions of dietary sodium are usually excess of requirements in the form of salt in many countries among adults and childrens, and then, leading to the excess weight gain. 2 Strikingly, both experimental data from animal and epidemiological data from clinical investigations in human being demonstrated that long-term HSD may cause cognitive dysfunction and brain tissue damage in adult individuals. 3,4 Data from rodents reported that HSD impaired cognitive function without changing blood pressure. 5,6 Furthermore, HSD disturbed the short-and long-term memory of mouse with corresponding increases in hippocampal oxidative stress and deregulation of synaptic protein/neurotrophin. 6 The importance of adequate maternal nutrition during the development for offspring's long-term physical health has

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