Maternal high-fat diet during suckling programs visceral adiposity and epigenetic regulation of adipose tissue stearoyl-CoA desaturase-1 in offspring

Butruille, Laura; Marousez, Lucie; Pourpe, Charlène; Oger, Frédérik; Lecoutre, Simon; Catheline, Daniel; Görs, Solvig; Metges, C. C.; Guinez, Céline; Laborie, Christine; Deruelle, Philippe; Eeckhoute, Jérôme; Breton, Christophe; Legrand, Philippe; Lésage, Jean; Eberlé, Delphine

doi:10.1038/s41366-018-0310-z

Cited by 50 publications

(42 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, it remains to be explored how the offspring response is further modulated by a combined effect of changes in dietary ALA and EPA/DHA levels, affecting liver but also other target tissues. For instance, in rats, maternal high-fat feeding during suckling alters the DNA methylation of Scd1 promoter in adipose tissue and programs visceral adiposity [81].…”

Section: Discussionmentioning

confidence: 99%

Stearoyl-CoA desaturase (scd1a) is epigenetically regulated by broodstock nutrition in gilthead sea bream (Sparus aurata)

et al. 2019

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Stearoyl-CoA desaturase (scd1a) is epigenetically regulated by broodstock nutrition in gilthead sea bream (Sparus aurata)

et al. 2019

View full text Add to dashboard Cite

“…These same authors further demonstrated that in newborn mice lactation keeps Fgf21 methylation to low levels. In a further recent study, Butruille et al [63] showed that maternal high-fat feeding during lactation induced qualitative changes in breast milk fatty acid (FA) composition (high n-6/n-3 polyunsaturated FA ratio and low medium-chain FA content). As a consequence, the offspring of adults fed HFD were predisposed to weight gain and showed increased visceral adipose tissue growth.…”

Section: Nutritional Factors Affecting Dna Methylationmentioning

confidence: 99%

Nutritional Factors, DNA Methylation, and Risk of Type 2 Diabetes and Obesity: Perspectives and Challenges

Parrillo

Spinelli

Nicolò

et al. 2019

IJMS

View full text Add to dashboard Cite

A healthy diet improves life expectancy and helps to prevent common chronic diseases such as type 2 diabetes (T2D) and obesity. The mechanisms driving these effects are not fully understood, but are likely to involve epigenetics. Epigenetic mechanisms control gene expression, maintaining the DNA sequence, and therefore the full genomic information inherited from our parents, unchanged. An interesting feature of epigenetic changes lies in their dynamic nature and reversibility. Accordingly, they are susceptible to correction through targeted interventions. Here we will review the evidence supporting a role for nutritional factors in mediating metabolic disease risk through DNA methylation changes. Special emphasis will be placed on the potential of using DNA methylation traits as biomarkers to predict risk of obesity and T2D as well as on their response to dietary and pharmacological (epi-drug) interventions.

show abstract

“…The metabolic imprinting during those periods, might influence the future development of obesity from infancy to the onset of adulthood. Epidemiological studies in humans have shown that maternal obesity and diabetes during fetal life and lactation are risk factors for the future development of obesity [22–24]. Likewise, maternal undernutrition was also shown to influence offspring predisposition to metabolic disorders [25, 26].…”

Section: Obesity Is At the Interplay Between Genetic And Environmentamentioning

confidence: 99%

The role of epigenetics in hypothalamic energy balance control: implications for obesity

Obri¹,

Claret²

2019

CST

View full text Add to dashboard Cite

Despite enormous social and scientific efforts, obesity rates continue to increase worldwide. While genetic factors contribute to obesity development, genetics alone cannot explain the current epidemic. Obesity is essentially the consequence of complex genetic-environmental interactions. Evidence suggests that contemporary lifestyles trigger epigenetic changes, which can dysregulate energy balance and thus contribute to obesity. The hypothalamus plays a pivotal role in the regulation of body weight, through a sophisticated network of neuronal systems. Alterations in the activity of these neuronal pathways have been implicated in the pathophysiology of obesity. Here, we review the current knowledge on the central control of energy balance with a focus on recent studies linking epigenetic mechanisms in the hypothalamus to the development of obesity and metabolic disorders.

show abstract

Maternal high-fat diet during suckling programs visceral adiposity and epigenetic regulation of adipose tissue stearoyl-CoA desaturase-1 in offspring

Cited by 50 publications

References 58 publications

Stearoyl-CoA desaturase (scd1a) is epigenetically regulated by broodstock nutrition in gilthead sea bream (Sparus aurata)

Stearoyl-CoA desaturase (scd1a) is epigenetically regulated by broodstock nutrition in gilthead sea bream (Sparus aurata)

Nutritional Factors, DNA Methylation, and Risk of Type 2 Diabetes and Obesity: Perspectives and Challenges

The role of epigenetics in hypothalamic energy balance control: implications for obesity

Contact Info

Product

Resources

About