Maternal hepcidin: the only player on the field?

Fleming, Robert E.; Parrow, Nermi L.

doi:10.1182/blood.2020007569

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…Accurate diagnosis, treatment and maintenance of iron and haemoglobin levels in pregnant women are a work in progress. This is because current diagnostic tests are not nationally standardised [21], and interpretation is problematic in the presence of inflammation and infection [22]. Treatment is dependent on diagnosis; therefore, reviewing the limitations to interpretation of standard tests is necessary to assess their effectiveness.…”

Section: Diagnosismentioning

confidence: 99%

The Ferritin, Hepcidin and Cytokines Link in the Diagnoses of Iron Deficiency Anaemia during Pregnancy: A Review

Chibanda,

Brookes,

Churchill

et al. 2023

IJMS

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Following a diagnosis of iron deficiency anaemia in pregnancy, iron supplements are prescribed using UK guidelines; however, despite this, the condition remains highly prevalent, affecting up to 30% of pregnant women in the UK. According to the World Health Organisation, it globally accounts for 45% in the most vulnerable groups of pregnant women and infants (<5 years old). Recently, the efficacy of iron replacement therapy and the effectiveness of current standard testing of iron parameters have been reviewed in order to evaluate whether a more accurate diagnosis can be made using alternative and/or supplementary markers. Furthermore, many questions remain about the mechanisms involved in iron metabolism during pregnancy. The most recent studies have shed more light on serum hepcidin and raised questions on the significance of pregnancy related inflammatory markers including cytokines in iron deficiency anaemia. However, research into this is still scarce, and this review aims to contribute to further understanding and elucidating these areas.

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Section: Diagnosismentioning

confidence: 99%