Maternal hepatitis B infection status and adverse pregnancy outcomes: a retrospective cohort analysis

Wu, Kaiqi; Wang, Hong; Li, Shuai; Zhang, Hong; Zhu, Bo

doi:10.1007/s00404-020-05630-2

Cited by 23 publications

(37 citation statements)

References 41 publications

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“…Placenta previa was investigated in 10 studies, 14–16,19–21,23,32,33,35–37 and there was no significant association between HBV infection and placenta previa ( p = 0.43); however, HBV+ patients seemed to have higher rates of placenta previa. The obtained OR was 1.15 (0.81–1.63).…”

Section: Resultsmentioning

confidence: 98%

“…The analysis of the results of 27 articles 14–17,19–39 showed a significant association between GMD and HBV infection among pregnant women with a OR (95% CI) = 1.32 (1.17–1.48) and p < 0.01 for the overall effect, and p < 0.01 and I 2 = 87.3% for heterogeneity (Figure 2). …”

Section: Resultsmentioning

confidence: 99%

“…Thirty eligible articles concerning the effect of HBV infection on pregnancy complications were included to assess the effects of HBV on preterm birth 14–17,19–25,27,28,30–38,40–47 . The results revealed significantly higher rates of preterm birth among HBV+ women compared to HBV− women ( p < 0.01) [OR (95% CI) = 1.26 (1.14–1.40)].…”

Section: Resultsmentioning

confidence: 99%

“…Twelve investigations 15,16,19,20,24,31,32,35–37,44–46 assessed the effects of HBV infection on PROM. However, PROM rate was higher among HBV infected women, it was insignificant ( p = 0.53) [OR (95% CI) = 1.11 (0.79–1.55)].…”

Section: Resultsmentioning

confidence: 99%

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The effects of hepatitis B virus infection on natural and IVF pregnancy: A meta‐analysis study

Farsimadan

Riahi

Muhammad

et al. 2021

Journal of Viral Hepatitis

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Background Hepatitis B virus (HBV) has been considered a significant cause of human reproductive failure in different studies; however, there is a considerable disagreement on the true impacts of HBV on female reproduction. This study has evaluated the impact of HBV infection on pregnancy complications in natural pregnancy and also on pregnancy outcomes in women undergoing in vitro fertilization (IVF) treatment. Method We searched Embase, Web of Science, PubMed and Google Scholar databases to identify the potentially relevant studies. Summary odds ratio (OR) or standardized mean difference (SMD) with 95% confidence interval (CI) was applied to assess the relationship. Heterogeneity testing, sensitivity analysis and publication bias testing were also performed. Results A total of 42 studies concerning the effect of HBV infection on the natural and IVF pregnancy were included in this study. Our meta‐analysis results revealed that HBV infection had a positive correlation to gestational diabetes mellitus (GDM) [OR = 1.32 (1.17–1.48) (p < 0.01)] and preterm birth [OR = 1.26 (1.14–1.40) (p < 0.01)] in natural pregnancy; however, HBV infection was not significantly associated with decreased fertility rates among the patients who underwent IVF. Conclusion This study revealed a strong association of GDM and preterm birth with higher rates of HBV infection in pregnant women. Also, our results suggested that HBV infection in patients undergoing IVF may not negatively influence the pregnancy outcome. It may be rational to conclude that IVF might be rather a safe and effective method for HBV+ females who desire to have children.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

The effects of hepatitis B virus infection on natural and IVF pregnancy: A meta‐analysis study

Farsimadan

Riahi

Muhammad

et al. 2021

Journal of Viral Hepatitis

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“…3 , 4 Placenta abruption, gestational hypertension, gestational diabetes mellitus, fetal growth restriction, higher risk of intraventricular hemorrhage in the fetus and neonatal asphyxia have also been associated with chronic HBV during pregnancy. 4 – 6 Whereas the consequences of an acute hepatitis B infection in pregnancy may include preterm labor leading to preterm birth, chronic HBV in pregnancy increases the risk of progression to cirrhosis. 6 The pregnancy complications may interact with maternal HBV infection and hepatitis flares, leading to serious and lethal complications.…”

Section: Introductionmentioning

confidence: 99%

Pregnant women’s hepatitis B vaccination coverage in Nigeria: a national pilot cross-sectional study

Eleje

Akaba

Mbachu

et al. 2021

Therapeutic Advances in Vaccines and Immunotherapy

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Objective: To determine the hepatitis B vaccination coverage, full-dose (⩾3) coverage and the associated factors affecting uptake among pregnant women. Methods: This was a cross-sectional study among pregnant women attending antenatal care in six tertiary hospitals across all the geopolitical zones of Nigeria. Pregnant women who consented to the study completed screening questions about their hepatitis B vaccination status and coverage. The main outcome measures were hepatitis B vaccination coverage rate, dose, and factors affecting uptake. Bivariate analysis was performed by the chi-square test and conditional logistic regression analysis was used to determine variables associated with uptake of the vaccination. Odds ratios (ORs) and adjusted odds ratios (aORs) were calculated and statistical significance was accepted when p-value was < 0.05. Results: Of 159 pregnant women who completed the interview questions, 21 [13.2%, 95% confidence interval (CI) 7.9–18.5%] were vaccinated for hepatitis B for one to three doses. The numbers of doses received were: three doses (8/159, 5.0%), two doses (5/159, 3.1%), and one dose (8/159, 5.0%). The reasons for non-uptake of vaccination included: lack of awareness of the vaccine 83/138 (60.1%), inadequate access to vaccine 11/138 (8.0%), and positivity to hepatitis B virus 10/138 (7.2%). The uptake of hepatitis B vaccination was significantly affected by the level of education (OR 0.284, 95% CI 0.08–1.01, p = 0.041), but in multivariable logistic regression, adjusted for confounders, the association between hepatitis B vaccination and participants’ level of education (aOR 3.09; 95% CI 0.95–10.16; p = 0.061) did not remain significant. Conclusions: In Nigeria, the national hepatitis B vaccination coverage among pregnant women appears poor, with the full-dose coverage even poorer. The level of education was not positively associated with uptake of hepatitis B vaccination, while lack of awareness of the vaccine was the commonest reason for non-uptake. Funding: TETFund National Research Fund 2019 (grant number TETFund/DR&D/CE/NRF/STI/33).

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Associations of hepatitis B and C in women aged 15–49 years with neonatal preterm birth in 66 high‐income countries, 1990–2019

Cao

Liu

2023

Intl J Gynecology & Obste

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ObjectiveTo assess the associations between hepatitis B and C in women aged 15–49 years and neonatal preterm birth in high‐income countries (HICs).MethodsThis ecological study collected hepatitis B and C prevalence data in women aged 15–49 years and age‐standardized incidence rates (ASIRs) of neonatal preterm birth in HICs in 1990–2019 from the Global Burden of Disease study. Estimated annual percentage changes (EAPCs) in hepatitis B and C prevalence and ASIRs of neonatal preterm birth were calculated to quantify their temporal trends. Pearson correlation tests and generalized additive mixed models were used to estimate the associations between hepatitis B and C prevalence and ASIR of neonatal preterm birth.ResultsAmong women aged 15–49 years in HICs, hepatitis B prevalence increased only in the Northern Mariana Islands (EAPC, 0.16 [95% confidence interval (CI), 0.05–0.27]) and the United Kingdom (EAPC, 0.08 [95% CI, 0.04–0.12]) and hepatitis C prevalence increased in more than 20% of HICs in 1990–2019, with the largest increase in Belgium (EAPC, 1.00 [95% CI, 0.65–1.35]). Nearly 80% of HICs showed an increasing trend in ASIR of neonatal preterm birth in 1990–2019, with the largest increase in Greece (EAPC, 3.91 [95% CI, 3.65–4.18]). A positive association between hepatitis C prevalence in women aged 15–49 years and ASIR of neonatal preterm birth was observed in Pearson correlation tests and generalized additive mixed models (P ≤ 0.01).ConclusionASIR of neonatal preterm birth was associated with hepatitis C prevalence in women aged 15–49 years in HICs. Universal screening for hepatitis C virus is recommended at least once for women of reproductive age and during each pregnancy.

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Maternal hepatitis B infection status and adverse pregnancy outcomes: a retrospective cohort analysis

Cited by 23 publications

References 41 publications

The effects of hepatitis B virus infection on natural and IVF pregnancy: A meta‐analysis study

The effects of hepatitis B virus infection on natural and IVF pregnancy: A meta‐analysis study

Pregnant women’s hepatitis B vaccination coverage in Nigeria: a national pilot cross-sectional study

Associations of hepatitis B and C in women aged 15–49 years with neonatal preterm birth in 66 high‐income countries, 1990–2019

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