Maternal hepatitis B infection and gestational diabetes mellitus

Lao, Terence T.; Chan, Ben; Leung, Wing Cheong; Ho, Lai Fong; Tse, Ka Yu

doi:10.1016/j.jhep.2007.02.014

Cited by 109 publications

(122 citation statements)

References 26 publications

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“…Recently, hepatitis B infection is associated with increased risk of gestational diabetes after adjusting for several confounders. 39 Moreover, hepatitis B infection is positively related to diabetes among Asian Americans. 40 Interestingly, the presence of adenovirus Ad-36 antibodies is associated with increased body weight in humans.…”

Section: Discussionmentioning

confidence: 99%

Obesity and hepatitis B infection are associated with increased risk of metabolic syndrome in university freshmen

Chiu

et al. 2007

Int J Obes

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Objective: To investigate the prevalence of metabolic syndrome and its associated risk factors in a cohort of university freshmen. Design: A cross-sectional study in a university health center in North Taiwan. Subjects: A total of 8226 students (mean age: 19.272.3 years) receiving pre-entrance health examinations and lifestyle questionnaires during the 2005-2006 academic year were recruited. Measurements: A fasting plasma glucose, lipids, uric acid and hepatitis B serology were measured for each subject. The prevalence of metabolic syndrome and its individual components were examined using the America Heart Association and National Heart Lung Blood Institute criteria. The risk factors for metabolic syndrome were identified using a multivariate logistic regression analysis. Results: The prevalence of overweight, obesity and metabolic syndrome was 12.7% (17.0% in men and 7.6% in women), 13.0% (18.4% in men and 6.4% in women) and 4.6% (6.4% in men and 2.4% in women). The risk for metabolic syndrome increased with an increase of body mass index and plasma uric acid level, and decreased with the vigorous physical activity and current alcohol drinking. Furthermore, as compared to subjects with seroprotective titers from hepatitis B vaccination (antiHBs( þ ) and anti-HBc(À)), those without protective titers of anti-HBs after vaccination or without hepatitis B infection (antiHBs(À) and anti-HBc(À)) had 34% higher risk for metabolic syndrome, and those with natural infection of hepatitis B (anti-HBc( þ )) had 58% higher risk for metabolic syndrome. Conclusions: Overweight, obesity and metabolic syndrome were more common among men than women in university freshmen. Hepatitis B vaccination with anti-HBs( þ ) was associated with a lower risk of metabolic syndrome as compared to antiHBs(À). However, hepatitis B infection presented with anti-HBc( þ ) was associated with a higher risk of metabolic syndrome. The interplay between hepatitis B infection, hepatitis B vaccination and metabolic syndrome needs further investigation.

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Section: Discussionmentioning

confidence: 99%

Obesity and hepatitis B infection are associated with increased risk of metabolic syndrome in university freshmen

Chiu

et al. 2007

Int J Obes

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“…When the reported prevalence of maternal HBsAg carriage is reviewed, in the pre-vaccination era, it was 6.6% in 1976 20 and 7.4% in 1981-1983. 3 Following the introduction of HBV vaccination, it was 10.0% overall and 8.4% in the locally-born residents in 1996, 16 and 8% in 1998-2001 21 . In our hospital in 1998-2008, it was 10.1% overall, being 10.1% in 1998 and 10.4% in 2008.…”

Section: Prevalence Of Hbv Infection In Hong Kongmentioning

confidence: 99%

Immune persistence after hepatitis B vaccination in infancy – Fact or fancy?

Lao

2016

Human Vaccines & Immunotherapeutics

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The hepatitis B vaccine has been introduced for more than 3 decades. In Hong Kong, excellent vaccine coverage through an efficient public health care system, together with supplemental programmes and easy availability of the vaccine, meant that most young pregnant women, and university students at entrance, should have been protected. Yet significant correlations in the prevalence of HBV infection with age were found in these groups of subjects, increasing from low to high endemicity rates from late teenage to the early twenties. This can only be attributed to vaccine failure, and there is cumulating evidence that several factors are involved, including the failure to respond to a primary series of hepatitis B vaccination in infancy, the waning of antibody titer with age, and loss of anamnestic response in a significant portion of the vaccinees. The duration of protection conferred by hepatitis B vaccination in infancy should be re-examined and remedial measures undertaken if its long term protection is found to be insufficient. Otherwise, the efforts to control HBV infection, especially in high endemicity regions, with universal vaccination in infancy would be rendered futile.

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“…Moreover, according to a recent meta-analysis, it was concluded that gestational diabetes mellitus is not attributable to CHB infection during pregnancy [43]. According to literature HBV can be a risk factor for diabetes mellitus and our finding could imply that the pregnant women positive for HBsAg are at a higher risk of developing gestational diabetes mellitus [17,18]. However, we cannot certify this as our study was cross sectional study.…”

Section: Discussionmentioning

confidence: 67%

“…It contributes significantly to the pool of chronic HBV carriers who act as a source of infection and it is suggested that transmission in sub-Saharan Africa occurs predominantly in childhood [16] hence the need to have control measures targeted at reducing this risk including mother to child transmission. Maternal HBV has been associated with adverse pregnancy and perinatal outcomes [17,18] making it important to screen and manage it effectively to prevent mother to child transmission and avert the adverse outcomes.…”

Section: Introductionmentioning

confidence: 99%