Maternal hematopoietic TNF, via milk chemokines, programs hippocampal development and memory

Liu, Bingfang; Zupan, Bojana; Laird, Emma; Klein, Shifra Liba; Gleason, Georgia; Bozinoski, Marjan; Toth, Judit Gal; Tóth, Miklós

doi:10.1038/nn.3596

Cited by 56 publications

(50 citation statements)

References 60 publications

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“…Taken together, the results presented in this study establish that, as reported for the neonatal porcine uterus and testis (Rahman et al 2014), as well as for the murine hippocampus (Liu et al 2014), lactocrine support is necessary for normal development of the neonatal porcine cervix. Disruption of cervical development by transient imposition of the lactocrine-null state for 2 days from birth altered the cervical developmental program in a manner that, as assessed on PND14, could not be reversed by returning gilts to nursing in synchrony with their littermates.…”

Section: Discussionsupporting

confidence: 88%

Effects of age, nursing, and oral IGF1 supplementation on neonatal porcine cervical development

Camp¹,

Wiley²,

Boulos³

et al. 2014

Reproduction

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Nursing supports neonatal porcine uterine and testicular development, however, lactocrine effects on cervical development are undefined. Studies were conducted to determine the effects of i) age and the imposition of the lactocrine-null state from birth (postnatal day 0 (PND0)) by milk replacer feeding on cervical histology; ii) imposition of the lactocrine-null state for 2 days from birth on cervical cell proliferation, as reflected by proliferating cell nuclear antigen immunostaining; and iii) a single feeding of colostrum or milk replacer, administered at birth, with or without oral IGF1, on cervical cell proliferation and phosphorylated AKT (pAKT) and B-cell lymphoma 2 (BCL2) protein levels at 12 h postnatal. Cervical crypt depth and height of luminal epithelium (LE) increased with age by PND14, when both responses were reduced in replacer-fed gilts. Cell proliferation was reduced in LE at PND2, and in crypt epithelium and stroma by PND14 in replacer-fed gilts. Returning replacer-fed gilts to nursing on PND2 did not rescue the cervical phenotype by PND14. A single feeding of colostrum, but not milk replacer, was sufficient to support cervical cell proliferation at 12 h postnatal. IGF1 supplementation induced cell proliferation in replacer-fed gilts, and increased cervical pAKT and BCL2 levels in colostrum-fed gilts and replacer-fed gilts at 12 h postnatal. Results indicate that age and nursing support porcine cervical development, support is initiated at first ingestion of colostrum, IGF1 may be lactocrine-active, and identification of lactocrine-active factors can be accomplished by 12 h postnatal using this bioassay system.

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Section: Discussionsupporting

confidence: 88%

Effects of age, nursing, and oral IGF1 supplementation on neonatal porcine cervical development

Camp¹,

Wiley²,

Boulos³

et al. 2014

Reproduction

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“…rat: Prado et al, 1997; red deer: Landete-Castillejos et al, 2001; rhesus macaque: Hinde et al, 2009; reviewed in Hinde, 2013), and neurobehavioral development (rat: Catalani et al, 2011; Liu et al, 2014; rhesus macaque: Dettmer et al, 2017; reviewed in Dettmer, et al 2014). To date, how the age of reproductive debut influences lactational performance remains largely unexplored.…”

mentioning

confidence: 99%

Age at reproductive debut: Developmental predictors and consequences for lactation, infant mass, and subsequent reproduction in rhesus macaques (Macaca mulatta)

Pittet

Johnson

Hinde

2017

American J Phys Anthropol

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Objectives The age at which females initiate their reproductive career is a critical life-history parameter with potential consequences on their residual reproductive value and lifetime fitness. The age at reproductive debut may be intimately tied to the somatic capacity of the mother to rear her young, but relatively little is known about the influence of age of first birth on milk synthesis within a broader framework of reproductive scheduling, infant outcomes, and other life-history tradeoffs. Material and Methods Our study investigated the predictors of age at first reproduction among 108 captive rhesus macaque (Macaca mulatta) females, and associations with their milk synthesis at peak lactation, infant mass and ability to subsequently conceive and reproduce. Results The majority of females reproduced in their fourth year (typical breeders); far fewer initiated their reproductive career one year earlier or one year later (respectively early and late breeders). Early breeders (3-year-old) benefited from highly favorable early life development (better juvenile growth, high dominance rank) to accelerate reproduction, but were impaired in milk synthesis due to lower somatic resources and their own continued growth. Comparatively, late breeders suffered from poor developmental conditions, only partially compensated by their delayed reproduction, and evinced compromised milk synthesis. Typical breeders not only produced higher available milk energy but also had best reproductive performance during the breeding and birth seasons following primiparity. Discussion Here we refine and extend our understanding of how life-history tradeoffs manifest in the magnitude, sources, and consequences of variation in age of reproductive debut. These findings provide insight into primate reproductive flexibility in light of constraints and opportunities.

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“…Female pups receiving poor maternal care will also show reduced maternal behaviors themselves, which is associated with epigenetic dysregulation in the brain (Weaver et al 2004 ;Champagne 2008 ). Additionally, milk composition during lactation (Liu et al 2014 ), microbiota (Stilling et al 2014 ), or odor cues (Debiec and Sullivan 2014 ) can also transfer environmental experiences from mother to offspring.…”

Section: Appendix 1: Experimental Methods To Examine Different Routesmentioning

confidence: 99%

Epigenetic Risk Factors for Diseases: A Transgenerational Perspective

Bohacek

Mansuy

2016

Epigenetics and Neuroendocrinology

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Each individual is determined by a combination of genetic and non-genetic factors that together shape physiological and biological functions during development and adulthood. While genetic features are embedded in the DNA sequence inherited from parents, non-genetic features (which include epigenetic modifi cations) are acquired through experiences and environmental exposure across life. However, it is now acknowledged that non-genetic features can also be inherited from parents and propagate across generations. This chapter discusses the concept of non-genetic germline inheritance in mammals and examines possible routes of transmission of non-genetic information involving germline-dependent and germline-independent modes of transfer. It reviews current evidence that environmental factors can induce non-genetic alterations in the germline that can impact behavioral and physiological features in the offspring. This chapter also addresses the underlying molecular mechanisms, provides initial insight into the implication of epigenetic marks and noncoding RNAs in male germ cells, and questions the way non-genetic modifi cations can be induced and maintained in germ cells. It highlights promising areas of current research and refl ects on evolutionary perspectives and future challenges.

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Maternal hematopoietic TNF, via milk chemokines, programs hippocampal development and memory

Cited by 56 publications

References 60 publications

Effects of age, nursing, and oral IGF1 supplementation on neonatal porcine cervical development

Effects of age, nursing, and oral IGF1 supplementation on neonatal porcine cervical development

Age at reproductive debut: Developmental predictors and consequences for lactation, infant mass, and subsequent reproduction in rhesus macaques (Macaca mulatta)

Epigenetic Risk Factors for Diseases: A Transgenerational Perspective

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