Maternal Hair Analysis for the Detection of Illicit Drugs, Medicines, and Alcohol Exposure During Pregnancy

Lendoiro, Elena; Gónzalez-Colmenero, Eva; Concheiro-Guisán, Ana; Castro, Ana de; Cruz, Angelines; López-Rivadulla, Manuel; Concheiro, Marta

doi:10.1097/ftd.0b013e318288453f

Cited by 54 publications

(43 citation statements)

References 32 publications

(47 reference statements)

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“…O consumo de drogas ilícitas é um importante problema de saúde pública que carece de estudos epidemiológicos no Brasil, não sendo tarefa fácil observar a ocorrência deste desfecho em mulheres gestantes que estejam em atendimento pré-natal, dada a baixa adesão ao atendimento, quer por questões individuais de vulnerabilidades das mulheres, quer por questões institucionais de dificuldade de acesso aos serviços 23 . Outro fator importante relacionado à dificuldade de observação desse fenômeno refere-se à guarda dos filhos; a possibilidade de perda do poder familiar pela mãe, caso ela seja usuária dependente de drogas.…”

Section: Discussionunclassified

“…O questionário é composto por 21 itens, que identificam os sintomas de ansiedade apresentados na última semana e quantificam sua intensidade em uma escala que varia de 0 (ausente) a 3 (severo). O escore total é alcançado pela soma dos escores apresentados em cada questão e permite a classificação do nível de ansiedade em normal (0-9 pontos), leve (10-18), moderada (19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29) e intensa (30-63 pontos) 19,20 . Essa variá-vel foi categorizada em ansiedade normal/leve e moderada/intensa.…”

Section: Métodosunclassified

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Prevalência e fatores associados ao uso de drogas ilícitas em gestantes da coorte BRISA

et al. 2016

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Section: Discussionunclassified

Section: Métodosunclassified

Prevalência e fatores associados ao uso de drogas ilícitas em gestantes da coorte BRISA

et al. 2016

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“…It has advantages as a screening tissue because it is easy to collect and has a long window of detection… up to months depending on the length of the hair (Lendoiro et al, 2013). Neonatal hair begins to protrude from the scalp around the beginning of the third trimester, and therefore may provide insight into third trimester drug use (Gareri and Koren, 2010; Lendoiro et al, 2013).…”

Section: Types Of Screening For Illicit Drugs In Pregnant Womenmentioning

confidence: 99%

Screening Pregnant Women and Their Neonates for Illicit Drug Use: Consideration of the Integrated Technical, Medical, Ethical, Legal, and Social Issues

2018

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North America is currently suffering from one of the worst epidemics of illicit drug use in recent history: the opioid crisis. Pregnant women are not immune to the ravages of substance misuse which affects themselves, their pregnancies, and the wider community. The prevalence of drug misuse in pregnancy is not well quantified due to the lack of good validated tests, cooperation between clinicians and scientists developing tests, and consensus as to who should be tested and how results should be used. A wide range of tissues can be tested for drug use, including maternal blood, urine, and hair; neonatal meconium, urine, and hair; and placenta and umbilical cord tissues. Testing methods range from simple spectrophotometry and clinical chemistry to sophisticated analytical HPLC or mass spectrometry techniques. The drive for ever greater accuracy and sensitivity must be balanced with the necessities of medical practice requiring minimally invasive sampling, rapid turnaround, and techniques that can be realistically utilized in a clinical laboratory. Better screening tests have great potential to improve neonatal and maternal medical outcomes by enhancing the speed and accuracy of diagnosis. They also have great promise for public health monitoring, policy development, and resource allocation. However, women can and have been arrested for positive drug screens with even preliminary results used to remove children from custody, before rigorous confirmatory testing is completed. Balancing the scientific, medical, public health, legal, and ethical aspects of screening tests for drugs in pregnancy is critical for helping to address this crisis at all levels.

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“…Kısa ve uzun vadeli problemlerden dolayı uyuşturucuya maruz kalan kadınlar için doğumdan hemen sonra bu durumun belirlenmesi sayesinde yenidoğanların uygun mü-dahale ve izlemi yapılabilmektedir. 41,42 Emre MUTLU ve ark.…”

Section: Gestasyonel İlaç Ve Madde Maruziyetinin Belirlenmesiunclassified

Incorporation of Drug and Substances in Hair

Mutlu¹,

Aşıcıoğlu²

2018

Turkiye Klinikleri J Foren Sci Leg Med

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aç, homojen bir yapıya sahip gibi görünse de aslında oldukça karmaşık olan biyolojisi kısmen anlaşılmıştır.1 Memelilerde saç; protein (%65-95), su (%15-35), lipit (%1-9) ve minerallerden (<%1) oluşan deri eklerinden biridir. Saç şaftında korteksi çevreleyen bir kütikül bulunduğu gibi, bazı saç tiplerinde santral medullayı çevreleyen ilave bir kütikülde bulunmaktadır.2 Saç apokrin, sebase ve ter bezleriyle yakın ilişkide olan cildin A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Saç; ilaç; birikim; kötüye kullanım A AB BS S T TR RA AC CT T In recent years hair has become a fundamental biological specimen, alternative to the usual samples blood and urine, for drug testing in the fields of forensic toxicology, clinical toxicology and clinical chemistry. Analytical results of drugs of abuse in hair provide useful information on chronic drug use. They are valuable to presume the history and severity of individual drug abuse and to provide supplementary information on drug use to facilitate interpretation of urine drug analysis. Hair testing has larger detection window. The sample collection is non-invasive. Another advantage of hair samples is that it can be stored at room temperature and do not need to be analyzed quickly after they are collected. Hair analysis is also used for detection of gestational drug exposure, doping control and detection of alcohol abuse. It has been reported that drugs are incorporated into hair by binding to such intracellular components as melanins, lipids, and proteins. It has been proposed that drugs and substances can enter into hair during at least 3 stages: from the blood during hair formation, from sweat and sebum, and from external environment. The aim of this review is to document and discuss the mechanisms of drug or substance accumulation in hair and its influencing factors, application of hair analysis.

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Maternal Hair Analysis for the Detection of Illicit Drugs, Medicines, and Alcohol Exposure During Pregnancy

Cited by 54 publications

References 32 publications

Prevalência e fatores associados ao uso de drogas ilícitas em gestantes da coorte BRISA

Prevalência e fatores associados ao uso de drogas ilícitas em gestantes da coorte BRISA

Screening Pregnant Women and Their Neonates for Illicit Drug Use: Consideration of the Integrated Technical, Medical, Ethical, Legal, and Social Issues

Incorporation of Drug and Substances in Hair

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