Maternal Gut Microbiota in Pregnancies Resulting in Down Syndrome Newborns – a Pilot Study

Hurşitoğlu, Mehmet; Kural, Alev; Kuras, Sibel; Akdeniz, Esra; Sezer, Salim; Çaypınar, Sema Süzen; Kazezoğlu, Cemal; Yaprak, Bülent; Karandere, Faruk; Guven, Hamit Zafer

doi:10.20471/acc.2021.60.04.20

Cited by 4 publications

(7 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The alteration of the gut microbiome in DS patients has also been reported [ 41 , 42 , 43 ]. Recent papers have indicated that pregnant mothers delivering babies with DS showed an altered microbiome compared to the control group.…”

Section: Introductionmentioning

confidence: 88%

“…Recent papers have indicated that pregnant mothers delivering babies with DS showed an altered microbiome compared to the control group. Clostridiaceae , Parteurellacae , and Pastereullaes were more abundant in DS pregnancies, compared to the controls in this pilot study [ 43 ], and this alteration might occur in the newborn babies as well, even if this was not investigated in these studies.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Down-Syndrome-Related Maternal Dysbiosis Might Be Triggered by Certain Classes of Antibiotics: A New Insight into the Possible Pathomechanisms

et al. 2023

View full text Add to dashboard Cite

Down syndrome (DS) is a leading human genomic abnormality resulting from the trisomy of chromosome 21. The genomic base of the aneuploidy behind this disease is complex, and this complexity poses formidable challenges to understanding the underlying molecular basis. In the spectrum of the classic DS risk factor associations, the role of nutrients, vitamins, and, in general, the foodborne-associated background, as part of the events ultimately leading to chromosome nondisjunction, has long been recognized as a well-established clinical association. The integrity of the microbiome is a basic condition in these events, and the dysbiosis may be associated with secondary health outcomes. The possible association of DS development with maternal gut microbiota should therefore require more attention. We have hypothesized that different classes of antibiotics might promote or inhibit the proliferation of different microbial taxa; and hence, we might find associations between the use of the different classes of antibiotics and the prevalence of DS through the modification of the microbiome. As antibiotics are considered major disruptors of the microbiome, it could be hypothesized that the consumption/exposure of certain classes of antibiotics might be associated with the prevalence of DS in European countries (N = 30). By utilizing three different statistical methods, comparisons have been made between the average yearly antibiotic consumption (1997–2020) and the estimated prevalence of people living with DS for the year 2019 as a percentage of the population in European countries. We have found strong statistical correlations between the consumption of tetracycline (J01A) and the narrow-spectrum, beta-lactamase-resistant penicillin (J01CF) and the prevalence of DS.

show abstract

Section: Introductionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Down-Syndrome-Related Maternal Dysbiosis Might Be Triggered by Certain Classes of Antibiotics: A New Insight into the Possible Pathomechanisms

et al. 2023

View full text Add to dashboard Cite

show abstract

“…It is now recognized that the microbiota may exert influence on cognitive function, and conversely, cognitive function may impact the composition of the microbiota [19][20][21]. The microbiota-gut-brain axis assumes a pivotal role not only in the development of neurodegenerative diseases [22] but also in the context of DS, as alterations in the intestinal microbiome have been documented in individuals with this condition [20,23]. A study identified a strong correlation between the prevalence of DS and the use of antibiotics, specifically tetracycline and beta-lactamase-resistant narrow-spectrum penicillin.…”

Section: The Oral Microbiota and Microbiome In Down Syndromementioning

confidence: 99%

“…In the case of DS patients, microbiota alterations have been identified even in the pregnant mother before birth. A pilot study indicated that pregnant women giving birth to infants with DS exhibited a distinct microbiome composition compared to the control group [23].…”

Section: The Oral Microbiota and Microbiome In Down Syndromementioning

confidence: 99%

A Comprehensive Review of the Relationship Between Oral Health and Down Syndrome

Botero,

Rodríguez-Medina,

Amaya-Sanchez

et al. 2024

Curr Oral Health Rep

View full text Add to dashboard Cite

Purpose of Review Individuals with Down syndrome (DS) may be more susceptible to oral disorders as a result of a combination of genetic factors, immunological disturbances, anatomical anomalies, and probable difficulties in maintaining adequate oral hygiene. Within this context, we provide a comprehensive review of the most important relationships between oral health and Down syndrome. Recent Findings Recent investigations suggest that a diminished diversity in the oral microbiome could emerge as a critical factor affecting oral health in individuals with DS. Plausible anatomical and metabolic peculiarities inherent to DS, including alterations in salivary characteristics, the presence of obstructive sleep apnea, elevated end glycation product levels, and hypothyroidism, may exert a significant influence on the composition and dynamics of the oral microbiome. A comprehensive analysis of the evidence implies a reduced occurrence of caries in individuals with DS. Furthermore, a recent meta-analysis indicates that gingivitis (OR 1.93; 95% CI 1.09–3.41) and periodontitis (OR 3.93; 95% CI 1.81–8.53) are more frequent in people with DS and strongly associated. Oral function in DS is also affected resulting in speech, breathing and eating problems. These findings underscore the necessity to implement targeted educational and awareness programs, along with specific intervention protocols, for the younger generations of individuals with DS, their families, and caregivers. Summary Although trisomy 21 itself does not determine a specific cause of oral diseases in DS, common oral health conditions such as gingivitis, periodontitis, and caries remain a matter of concern. The nexus between insufficient plaque control, distinctive oral characteristics, and reluctance to engage in treatment persists as noteworthy determinants. The necessity for oral health professionals to exercise patience and commitment when addressing oral care for individuals with Down syndrome is crucial.

show abstract

“…Gastroesophageal reflux is the upward movement of stomach contents from the lower end of the esophagus and even coming into the mouth. Physiologically, it is an event that can be observed for a short time 10-15 times a day, normally after something is eaten [5][6][7]. It does not cause symptoms and complications due to the existing protection mechanisms of the esophagus.…”

Section: Medicine Science International Medical Journalmentioning

confidence: 99%

Frequency of GERD in women of childbearing age in Malatya region

Aladag¹,

Aladağ²

2023

Med-Science

View full text Add to dashboard Cite

Gastroesophageal reflux disease (GERD) is frequently seen not only in our country but also all over the world. GERD not only impairs health and quality of life, but also causes serious financial losses in the working population. In this study, our aim is to determine the frequency of gastroesophageal reflux disease among female healthcare professionals of childbearing age in our region. Questions were asked about demographic data such as weight, age, height, BMI, medical history, and gastroesophageal reflux of female healthcare workers, whose data were generated by us. The answers to the questionnaires were collected and evaluated retrospective. All participants in the study were women. This study was carried out on 1224 female healthcare workers of reproductive age working in Malatya Turgut Özal University training and research hospital. Approximately 1150 of the employees who were distributed questionnaires filled out the questionnaires. The mean age of the female healthcare workers of childbearing age was 30.01±5.38 years, between 19-50. The mean height of the healthcare workers was 1.64±7.8 meters, the average weight was 68.05±13.2 kg, and their body mass index (BMI) was 27.4±3.6 kg/m². The frequency of GERD in the study group was found to be positive in 24%. 38.5% of the healthcare workers had previously gone to the doctor with complaints of pyrosis and/or regurgitation. A significant relationship was found between GERD and stress, fizzy drinks, lying down after meals, and family history of GERD. There was no significant relationship between the smoking and coffee use and age of the participants in the study in terms of the presence of GERD.We think that gastroesophageal reflux symptoms are common due to stress, unbalanced diet, irregular sleep and lifestyle habits due to the COVID pandemic in the last two years due to the fact that the participants in the study were healthcare professionals. Among our healthcare professionals, both pyrosis and other GERD symptoms were found to be higher than some of the previous studies, similar to those in our country. We think that the reason for this is that the extremely stressful work of health workers in the last 2 years has contributed to this. As it is known, health workers have worked very hard in the last 2 years, they did not even use their annual leaves, even those who wanted to retire could not retire. We think that this stress environment may also contribute to GERD symptoms.

show abstract

Maternal Gut Microbiota in Pregnancies Resulting in Down Syndrome Newborns – a Pilot Study

Cited by 4 publications

References 19 publications

Down-Syndrome-Related Maternal Dysbiosis Might Be Triggered by Certain Classes of Antibiotics: A New Insight into the Possible Pathomechanisms

Down-Syndrome-Related Maternal Dysbiosis Might Be Triggered by Certain Classes of Antibiotics: A New Insight into the Possible Pathomechanisms

A Comprehensive Review of the Relationship Between Oral Health and Down Syndrome

Frequency of GERD in women of childbearing age in Malatya region

Contact Info

Product

Resources

About