Maternal Food Consumption during Pregnancy and the Longitudinal Development of Childhood Asthma

Willers, Saskia M.; Wijga, Alet H.; Brunekreef, Bert; Kerkhof, Marjan; Gerritsen, Jorrit; Hoekstra, M. O.; Jongste, Johan C. de; Smit, Henriëtte A.

doi:10.1164/rccm.200710-1544oc

Cited by 123 publications

(137 citation statements)

References 36 publications

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“…At least one serve a fish a week by mothers during pregnancy was protective for eczema in their children at five years of age in one study, while none of the other foods tested (including fruit and vegetables, grains and fats) showed any consistent associations [58]. One study [60] also found no association between vitamin D from food consumed during pregnancy and development of eczema in children at five years of age.…”

Section: Observational Studiesmentioning

confidence: 89%

Does maternal diet during pregnancy and lactation affect outcomes in offspring? A systematic review of food-based approaches

2014

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Abstract:Objectives: To investigate the relationship between maternal diet during pregnancy and lactation and development of atopic disorders in childhood. Methods:We included studies published up to August 2011 which either assessed food-based maternal dietary interventions or examined associations between maternal dietary intake during pregnancy and/or lactation and allergic outcomes (eczema, asthma, hay fever and sensitization) in their children. Results:We included 43 studies (over 40 000 children): 11 intervention studies (including seven RCTs), 27 prospective cohort studies, four retrospective cohort studies and one case-control study.In the RCTs, no significant difference was noted overall in the prevalence of eczema and asthma in the offspring of women on diets free from common food allergens during pregnancy. The prospective cohorts investigated a large number of potential associations, but reported few significant associations between maternal dietary intake and development of allergy. Maternal diets rich in fruits and vegetables, fish and foods containing vitamin D and 'Mediterranean' dietary patterns were among the few consistent associations with lower risk of allergic disease in their children. Foods associated with higher risk included vegetable oils and margarine, nuts and fast food. Conclusion:This review did not find widespread or consistent links between mother's dietary intake and atopic outcomes in their children. However, maternal consumption of 'Mediterranean' dietary patterns, diets rich in fruits and vegetables, fish and vitamin D containing foods were suggestive of benefit, requiring further evaluation.

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Section: Observational Studiesmentioning

confidence: 89%

Does maternal diet during pregnancy and lactation affect outcomes in offspring? A systematic review of food-based approaches

2014

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“…These observations are in contrast to results from previous studies, which mainly, but not consistent, suggest that maternal fish intake during pregnancy protects against the development of childhood asthma and atopy. [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] Observational studies in large cohorts observed lower incidence of eczema in offspring of mothers with the highest fish consumption during pregnancy, 19,21 but not lower incidences of wheezing or asthma. In the Netherlands, fish consumption is relatively low, which can explain the differences in the observations.…”

Section: Maternal Fish Consumption and Atopic Symptoms Etm Leermakersmentioning

confidence: 98%

“…22 It is difficult to determine whether the suggested beneficial effects that were observed in previous observational studies were due to fish consumption and not to other aspects from maternal diet or lifestyle. None of the previous studies that found an association of maternal fish consumption during pregnancy with childhood asthma did take maternal body mass index, folic acid supplement use, alcohol use and distress during pregnancy into account.…”

Section: Maternal Fish Consumption and Atopic Symptoms Etm Leermakersmentioning

confidence: 99%

“…7 Many observational and interventional studies, explored the associations of maternal fish consumption or fish oil supplementation during pregnancy with the risks of childhood asthma and atopy. [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] Although these studies showed a protective effect on at least one outcome, they were not all able to adjust for potential confounders. Also, previous intervention studies differed in selection of participants, types of intervention and definition of outcome measures.…”

Section: Introductionmentioning

confidence: 99%

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Maternal fish consumption during pregnancy and risks of wheezing and eczema in childhood: The Generation R Study

et al. 2013

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BACKGROUND/OBJECTIVES: Maternal fish consumption during pregnancy might influence the fetal immune system through anti-inflammatory effects of omega-3 fatty acids, and might affect the risks of childhood asthma and atopy. In Generation R, a prospective cohort study in the Netherlands, we examined the associations of first trimester fish consumption with childhood wheezing and eczema in the first 4 years of life. METHODS: In total, 2976 mothers completed a 293-item semiquantitative food frequency questionnaire covering dietary intake in the first trimester. The occurrence of wheezing and eczema was yearly assessed by questionnaires. RESULTS: Median weekly fish consumption was 83 (95% range 0-316) grams per week. We observed no consistent associations of maternal total-, lean-or fatty-fish consumption during pregnancy with the risks of childhood wheezing. Maternal shellfish consumption of 1-13 g per week was associated with overall increased risks of childhood wheezing and eczema (OR 1.20 (1.04, 1.40) and OR 1.18 (1.01, 1.37), respectively). Maternal fatty fish consumption of 35-69 g per week was associated with increased overall risks of childhood eczema (OR 1.17 (1.00, 1.38)), but maternal total-or lean-fish consumption was not. CONCLUSIONS: During pregnancy, shellfish consumption was associated with increased risks of wheezing and eczema, while fatty fish consumption was associated with a higher risk of eczema only. Maternal total fish or lean fish consumption were not associated with wheezing or eczema. Further studies are needed to replicate these findings and to explore underlying mechanisms.

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“…[4][5][6][7][8] Several observational studies have reported protective associations between increased fish intake in pregnancy and allergic disease symptoms in offspring from infancy to 6 years of age. [9][10][11][12][13][14] However, these observational studies are unable to establish causality because of the difficulty in adjusting for complex confounding factors. 15 Randomized controlled trials (RCTs) of n-3 LCPUFA supplementation during pregnancy have reported protective effects; however, apart from 1 16-year registry based follow-up, 16 all reported allergic disease outcomes are in early childhood (between 1 and 3 years of age).…”

mentioning

confidence: 99%

Prenatal Fish Oil Supplementation and Allergy: 6-Year Follow-up of a Randomized Controlled Trial

et al. 2016

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BACKGROUND AND OBJECTIVE: Evidence from randomized controlled trials in early infancy suggest that prenatal supplementation with Ω-3 (n-3) long-chain polyunsaturated fatty acids (LCPUFA) reduces the incidence of allergic disease characterized by an immunoglobulin E (IgE) response. We aimed to determine whether protective effects were evident in the 6-year-old offspring of women supplemented with n-3 rich fish oil during pregnancy.

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Maternal Food Consumption during Pregnancy and the Longitudinal Development of Childhood Asthma

Abstract: Results of this study indicate an increased risk of daily versus rare consumption of nut products during pregnancy on childhood asthma outcomes. These findings need to be replicated by other studies before dietary advice can be given to pregnant women.

Cited by 123 publications

References 36 publications

Does maternal diet during pregnancy and lactation affect outcomes in offspring? A systematic review of food-based approaches

Does maternal diet during pregnancy and lactation affect outcomes in offspring? A systematic review of food-based approaches

Maternal fish consumption during pregnancy and risks of wheezing and eczema in childhood: The Generation R Study

Prenatal Fish Oil Supplementation and Allergy: 6-Year Follow-up of a Randomized Controlled Trial

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