Maternal flaxseed oil intake during lactation changes body fat, inflammatory markers and glucose homeostasis in the adult progeny: role of gender dimorphism

Guarda, Deysla Sabino; Moura, Egberto Gaspar de; Carvalho, Janaíne Cavalcanti; Reis, Adelina Martha dos; Soares, P.N.; Lisboa, Patrícia Cristina; Figueiredo, Mariana Sarto

doi:10.1016/j.jnutbio.2016.05.011

Cited by 19 publications

(12 citation statements)

References 38 publications

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“…Other authors found a reduction of cholesterol values in rats orally treated with flaxseed lignan concentrate over a period of seven weeks (Zanwar et al, 2013). In the same way, Guarda et al (2016), demonstrated that ingestion of flaxseed oil by lactating rats reduces cholesterol levels in milk, suggesting also a hypocholesterolemic effect of that product. In the present study, it was observed that animals supplemented with flaxseed presented a statistically significant reductionof LDL/HDL ratio.…”

Section: Discussionmentioning

confidence: 76%

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Effects of Flaxseed Supplementation on Lipid Metabolism, Oxidative Balance and Genetic Damage in Goats

Cecchini¹,

Roma²,

Magnago³

et al. 2018

American Journal of Animal and Veterinary Sciences

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Epidemiological evidence indicates that flaxseed reduces oxidative stress and cholesterol levels in blood. In this study we evaluated the lipid profile, oxidation of plasma lipids and genetic damage in goats fed on a diet supplemented with flaxseed. Thirteen adult male goats were split in two experimental groups; one of them was fed on a conventional diet of alfalfa and ground corn and the other group was fed on the same diet supplemented with 5% of flaxseed. Blood samples were obtained every 7 days to quantify the Thiobarbituric Acid-Reactive Substances (TBARs), total cholesterol, HDL, LDL and triacylglycerols. Additionally, 3 blood samples and 3 oral mucosa samples were taken to each animal every 15 days to perform comet assay and micronucleus test. Flaxseed supplementation produces a remarkable antioxidant effect in plasma in a three months period that could explain the antigenotoxic effect determined through both micronucleus test and comet assay. In addition, we also found a reduction of LDL/HDL ratio and cholesterol levels in animals supplemented with flaxseed.

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Section: Discussionmentioning

confidence: 76%

“…In vitro studies showed that flaxseed protein hydrolysates have antioxidant and anti-inflammatory activity, as well as cholesterol-lowering ability (Silva et al, 2013). It has a high oil content (32-45%), of which 51-55% is Alpha-Linolenic Acid (ALA, n-3) and 15-18% is Linoleic Acid (LA, n-6) (Guarda et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Effects of Flaxseed Supplementation on Lipid Metabolism, Oxidative Balance and Genetic Damage in Goats

Cecchini¹,

Roma²,

Magnago³

et al. 2018

American Journal of Animal and Veterinary Sciences

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“…(28) (29). Finally, we could not analyze the direction of causality of the molecular changes observed at PD42 in pups experiencing catch-up growth since the Wistar rat model of intrauterine growth restriction induced by calorie restriction throughout gestation used in the present study did not include tissues at birth: a few pups were removed to equal litter sizes within groups but they were insufficient in number to provide tissue samples at birth.…”

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confidence: 97%

Dlk1 expression relates to visceral fat expansion and insulin resistance in male and female rats with postnatal catch-up growth

et al. 2019

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Background: Although prenatal and postnatal programming of metabolic diseases in adulthood is well established, the mechanisms underpinning metabolic programming are not. Dlk1, a key regulator of fetal development, inhibits adipocyte differentiation and restricts fetal growth. Methods: Assess DLk1 expression in a Wistar rat model of catch-up growth following intrauterine restriction. Dams fed ad libitum delivered control pups (C) and dams on a 50% calorie-restricted diet delivered pups with low birth weight (R). Restricted offspring fed a standard rat chow showed catch-up growth (R/C) but those kept on a calorie-restricted diet did not (R/R). Results: Decreased Dlk1 expression was observed in adipose tissue and skeletal muscle of R/C pups along with excessive visceral fat accumulation, decreased circulating adiponectin, increased triglycerides and HOMA-IR (from p<0.05 to p<0.0001). Moreover, in R/C pups the reduced Dlk1 expression in adipose tissue and skeletal muscle correlated with visceral fat (r= −0.820, p<00001) and HOMA-IR (r= −0.745, p=0.002). Conclusions: Decreased Dlk1 expression relates to visceral fat expansion and insulin resistance in a rat model of catch-up growth following prenatal growth restriction. Modulation of Dlk1 expression could be among the targets for the early prevention of fetal programming of adult metabolic disorders.

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“…In Blondeau et al study, 20 in utero exposure to hyperglycaemia in Sprague-Dawley rats did not alter total cholesterol, triglycerides and HDL-C serum levels in adult life. Guarda et al 21 observed that the maternal intake of a diet high in flaxseed oil during lactation did not alter total cholesterol serum levels, although an increase in triglyceride was observed in male offspring. Nevertheless, there was no difference in female offspring at 180 days.…”

Section: Discussionmentioning

confidence: 99%

Sexual dimorphism on aortic remodelling in rats offspring from diabetic mothers and the role of flaxseed oil in this effect

Vicente

Correia-Santos

Chagas

et al. 2019

J Dev Orig Health Dis

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Diabetes during pregnancy is associated with aortic remodelling in the fetus, stimulating the development of cardiovascular diseases in adult life. However, studies suggest that the use of foods high in omega-3 fatty acid, such as flaxseed oil, may reverse this effect of metabolic programming. This study aimed at investigating whether the effects of diabetes in mothers are passed on to their offspring in a gender-specific manner and whether the flaxseed oil used during pregnancy and lactation reverses or not the possible negative effects of this programming. Diabetic female rats (n = 18) were mated and allocated into three groups (n = 6): high-fat group (HG); flaxseed oil group (FOG) and control group (CG) (nondiabetic rats) during pregnancy and lactation. On the 21st day, male and female pups were weaned on a standard diet until 180 days. Aorta histomorphometry was analysed. Intima-media layer thickness was larger in FOG than CG in male (+15%) and than HG in female (+13.7%). Male FOG (+11.5%) showed higher amount of elastic fibre than CG. Maternal intake of flaxseed oil during pregnancy and lactation of diabetic mothers program the offspring to increase aorta intima-media layer thickness in adulthood and preserves aorta elastic fibres deposition in male offspring.

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Maternal flaxseed oil intake during lactation changes body fat, inflammatory markers and glucose homeostasis in the adult progeny: role of gender dimorphism

Cited by 19 publications

References 38 publications

Effects of Flaxseed Supplementation on Lipid Metabolism, Oxidative Balance and Genetic Damage in Goats

Effects of Flaxseed Supplementation on Lipid Metabolism, Oxidative Balance and Genetic Damage in Goats

Dlk1 expression relates to visceral fat expansion and insulin resistance in male and female rats with postnatal catch-up growth

Sexual dimorphism on aortic remodelling in rats offspring from diabetic mothers and the role of flaxseed oil in this effect

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