Maternal–fetal status of copper, iron, molybdenum, selenium and zinc in patients with gestational diabetes

Al-Saleh, Eyad; Nandakumaran, Moorkath; Al-Shammari, Majed; Al-Harouny, A

doi:10.1080/14767050412331283139

Cited by 49 publications

(49 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The serum selenium concentrations of Hungarian healthy pregnant women are lower than most results reported in the literature [4,18,[23][24][25][26][27], although comparison of selenium concentrations is rendered more difficult by measurements of selenium in different compartments and at different gestational weeks (Table 4).…”

Section: Discussioncontrasting

confidence: 62%

Serum Selenium Concentrations Correlate Significantly with Inflammatory Biomarker High-sensitive CRP Levels in Hungarian Gestational Diabetic and Healthy Pregnant Women at Mid-pregnancy

Molnár

Garamvölgyi

Herold

et al. 2007

Biol Trace Elem Res

View full text Add to dashboard Cite

Selenium is an essential trace element and a component of various enzymes with antioxidant functions. High-sensitive C-reactive protein (hsCRP) is an early indicator of increased lipid peroxidation. The serum selenium concentration, lipid parameters, and hsCRP values of gestational diabetic pregnant women (GD), control pregnant women (CP), and healthy nonpregnant controls (HC) were compared. Blood was taken between the 24th and the 28th week of pregnancy when the oral glucose tolerance test was performed. Selenium concentration was determined by atomic absorption spectrometry after hydride generation. HsCRP was measured by immunturbidimetry. HC had significantly higher serum selenium concentrations than GD and CP women (HC = 77.4 +/- 14.82, GD = 51.7 +/- 11.62, and CP = 40.5 +/- 8.03 microg/l, respectively). HsCRP values of both GD and nondiabetic pregnant women were significantly higher compared to controls. Significant negative correlations were found between serum selenium and total cholesterol, low-density lipoprotein cholesterol, and hsCRP values indicating that low selenium levels are associated with increased lipid peroxidation. Serum selenium concentrations of Hungarian pregnant women are low compared to internationally published data.

show abstract

Section: Discussioncontrasting

confidence: 62%

Serum Selenium Concentrations Correlate Significantly with Inflammatory Biomarker High-sensitive CRP Levels in Hungarian Gestational Diabetic and Healthy Pregnant Women at Mid-pregnancy

Molnár

Garamvölgyi

Herold

et al. 2007

Biol Trace Elem Res

View full text Add to dashboard Cite

show abstract

“…For instance, hemoglobin concentrations in pregnancy were positively associated with the risk of GDM in some (42,45,61,62,67) although not all studies (41,43,47,50,56,57,59). Studies examining serum iron concentration in relation to GDM risk have also been conflicting with mixed reports of positive (31,41,45,47), negative (68), or no association (59,69,70) with GDM status. However, the majority of these studies were of small sample size, and inferences from these studies were further limited by insufficient control for potential confounders, such as prepregnancy BMI.…”

Section: Other Indicators Of Iron Status and Gdm Riskmentioning

confidence: 96%

“…However, the majority of these studies were of small sample size, and inferences from these studies were further limited by insufficient control for potential confounders, such as prepregnancy BMI. Despite these limitations, a meta-analysis (48) pooling data from 7 studies (31,41,45,47,59,70,71) including 337 GDM cases showed that women with GDM had higher concentrations of serum iron than those without (pooled mean difference: 200 mg/L; 95% CI: 147, 253). Future prospective studies of large sample sizes and with a comprehensive adjustment of potential confounders are warranted to further investigate the roles of these iron indicators in the development of GDM.…”

Section: Other Indicators Of Iron Status and Gdm Riskmentioning

confidence: 99%

Dietary iron intake, iron status, and gestational diabetes

Zhang

Rawal

2017

The American Journal of Clinical Nutrition

View full text Add to dashboard Cite

Pregnant women are particularly vulnerable to iron deficiency and related adverse pregnancy outcomes and, as such, are routinely recommended for iron supplementation. Emerging evidence from both animal and population-based studies, however, has raised potential concerns because significant associations have been observed between greater iron stores and disturbances in glucose metabolism, including increased risk of type 2 diabetes among nonpregnant individuals. Yet, the evidence is uncertain regarding the role of iron in the development of gestational diabetes mellitus (GDM), a common pregnancy complication which has short-term and long-term adverse health ramifications for both women and their children. In this review, we critically and systematically evaluate available data examining the risk of GDM associated with dietary iron, iron supplementation, and iron status as measured by blood concentrations of several indicators. We also discuss major methodologic concerns regarding the available epidemiologic studies on iron and GDM.Am J Clin Nutr 2017;106(Suppl):1672S-80S.

show abstract

“…Selenium is involved in processes that protect the cell against oxidative damage by peroxides produced from lipid metabolism [4]. There is an increased requirement for selenium during pregnancy, presumably for fetal growth, which manifests as decreasing maternal blood and tissue selenium concentrations [5,6]. These decreases are greater in pregnant women with gestational or pre-existing diabetes.…”

Section: Introductionmentioning

confidence: 98%

“…These decreases are greater in pregnant women with gestational or pre-existing diabetes. A lower level of selenium has been described in GDM, and it has been shown that there was a inverse relationship with this trace element status and glucose tolerance [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Serum Selenium Levels in Turkish Women with Gestational Diabetes Mellitus, Glucose Intolerants, and Normal Controls

Kılınç

Güven

Ezer

et al. 2008

Biol Trace Elem Res

View full text Add to dashboard Cite

The aim of the study was to investigate the association between serum selenium levels in patients with gestational diabetes mellitus (GDM) and glucose intolerants and compare them with those of glucose-tolerant pregnant women. This cross-sectional study was prospectively performed in a total of 178 pregnant women undergoing a 50-g oral glucose tolerance test between 24 and 28 weeks of gestation who were grouped according to their status of glucose tolerance as with gestational diabetes (group A, abnormal 1- and 3-h glucose tolerance test; n = 30), glucose intolerant (group B, abnormal 1-h but normal 3-h glucose tolerance test; n = 47), or normal controls (group C, normal 1-h glucose test; n = 101). Serum selenium levels were measured with a graphite furnace atomic absorption spectrophotometer using a matrix modifier. Median maternal age and gestational age at the time of diagnosis in group A (gestational age = 24.8 [24-27]), group B (gestational age = 24.7 [24-27]), and group C (gestational age = 25 [24-28]) did not differ. Patients with gestational diabetes mellitus and those with glucose intolerants had lower selenium level than that of the normal pregnant women (P< 0.001). There was a significant inverse correlation between selenium and blood glucose level, and also selenium supplementation might prove beneficial on patients with GDM and prevent or retard them from secondary complications of diabetes.

show abstract

Maternal–fetal status of copper, iron, molybdenum, selenium and zinc in patients with gestational diabetes

Abstract: We speculate that altered maternal-fetal status of some essential trace elements in gestational diabetes patients could have deleterious influences on the health of the mother as well as the fetus and newborn.

Cited by 49 publications

References 16 publications

Serum Selenium Concentrations Correlate Significantly with Inflammatory Biomarker High-sensitive CRP Levels in Hungarian Gestational Diabetic and Healthy Pregnant Women at Mid-pregnancy

Serum Selenium Concentrations Correlate Significantly with Inflammatory Biomarker High-sensitive CRP Levels in Hungarian Gestational Diabetic and Healthy Pregnant Women at Mid-pregnancy

Dietary iron intake, iron status, and gestational diabetes

Evaluation of Serum Selenium Levels in Turkish Women with Gestational Diabetes Mellitus, Glucose Intolerants, and Normal Controls

Contact Info

Product

Resources

About