Maternal-fetal resource allocation: Co-operation and conflict

Fowden, Abigail L.; Moore, Tom

doi:10.1016/j.placenta.2012.05.002

Cited by 91 publications

(80 citation statements)

References 50 publications

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“…From an evolutionary perspective, the conflict theory (also known as kinship theory of genomic imprinting) proposes that imprinted genes (genes that are expressed in a parentspecific manner) have evolved because of the need to allocate maternal resources to the offspring [118]. Indeed, paternally derived genes are thought to support the extraction of maternal resources for the benefit of a unique offspring, and, on the contrary, maternally derived genes tend to counteract this effect in order to prevent depletion of resources by allocating them equally among different offspring [78,119].…”

Section: Imprinted Genes In Maternal-fetal Resource Allocationmentioning

confidence: 99%

The Role of Placental Nutrient Sensing in Maternal-Fetal Resource Allocation1

Díaz

Powell

Jansson

2014

Biology of Reproduction

115

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The placenta mediates maternal-fetal exchange and has historically been regarded as a passive conduit for nutrients. However, emerging evidence suggests that the placenta actively responds to nutritional and metabolic signals from the mother and the fetus. We propose that the placenta integrates a multitude of maternal and fetal nutritional cues with information from intrinsic nutrient-sensing signaling pathways to match fetal demand with maternal supply by regulating maternal physiolo-

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Section: Imprinted Genes In Maternal-fetal Resource Allocationmentioning

confidence: 99%

The Role of Placental Nutrient Sensing in Maternal-Fetal Resource Allocation1

Díaz

Powell

Jansson

2014

Biology of Reproduction

115

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“…Maternal endometrial tissues are in direct contact with fetal trophoblast with paternal antigens. Decidualization both supports and limits the invasion and growth of the implanting embryo because of maternal-fetal genetic and immunological co-operation and conflict (Emera et al 2012;Fowden and Moore 2012).…”

Section: Impaired Decidualization and Placentation In Preeclampsiamentioning

confidence: 99%

“…Paternal and fetal fitness genes have evolved to extract a high plane of maternal resources. On the other hand, maternal fitness genes limit fetal growth (Fowden and Moore 2012). Decidualization is an essential phenomenon evolved as a protective mechanism for the mother (Haig 1993;Pijnenborg et al 2008).…”

Section: Impaired Decidualization and Placentation In Preeclampsiamentioning

confidence: 99%

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The Impact of Maternal-Fetal Genetic Conflict Situations on the Pathogenesis of Preeclampsia

Kobayashi

2015

Biochem Genet

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Preeclampsia leads to maternal and perinatal morbidity and mortality. The literature in English was reviewed to summarize recent advances in understanding the global gene expression changes in the pathogenesis of preeclampsia. We identified at least eight consistently enriched categories, relating to pregnancy maintenance, metabolism, oxidative stress, cell cycle regulation, implantation, decidualization, immune modulation, and vascular function. Expression profiling in preeclampsia placenta and normal placenta revealed 140 transcripts that were significantly differentially expressed, 30 (21.4%) of which were evolved for the protection of the mother, approximately three times less than the number of genes evolved for the benefit of the fetus [110 genes (78.6%)] in preeclampsia placenta versus normal placenta. The genome-wide analysis emphasizes the dysfunctional decidualization as the main mechanism involved in the development of preeclampsia. These genetic signaling events may occur from an imbalance in the maternal-fetal genetic response in the affected placenta. This is to our knowledge the first report on the pathogenesis of preeclampsia, in which preeclampsia may occur as a genetic consequence of maternal-fetal conflict situations during the early decidualization process.

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“…Interestingly, a character transformation resulted in the stem lineage of Afrotheria [57], representing the first morphological support for this novel taxon. Later, other studies dealt with similar and other characters [6,[58][59][60] and included aspects of behavior and evolutionary traits [8,15,[61][62][63][64][65][66]. Despite interesting progress, particularly the interhaemal barrier as the feature which attracted most interest differed in the interpretation of ancestral or derived conditions, mainly because the published studies were based on different taxa sampling or rooting of the respected trees [5].…”

Section: Molecular Phylogenymentioning

confidence: 99%

Placental Evolution within the Supraordinal Clades of Eutheria with the Perspective of Alternative Animal Models for Human Placentation

Mess

2014

Advances in Biology

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Here a survey of placental evolution is conducted. Placentation is a key factor for the evolution of placental mammals that had evolved an astonishing diversity. As a temporary organ that does not allow easy access, it is still not well understood. The lack of data also is a restriction for better understanding of placental development, structure, and function in the human. Animal models are essential, because experimental access to the human placenta is naturally restricted. However, there is not a single ideal model that is entirely similar to humans. It is particularly important to establish other models than the mouse, which is characterised by a short gestation period and poorly developed neonates that may provide insights only for early human pregnancy. In conclusion, current evolutionary studies have contributed essentially to providing a pool of experimental models for recent and future approaches that may also meet the requirements of a long gestation period and advanced developmental status of the newborn in the human. Suitability and limitations of taxa as alternative animal models are discussed. However, further investigations especially in wildlife taxa should be conducted in order to learn more about the full evolutionary plasticity of the placenta system.

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Maternal-fetal resource allocation: Co-operation and conflict

Cited by 91 publications

References 50 publications

The Role of Placental Nutrient Sensing in Maternal-Fetal Resource Allocation1

The Role of Placental Nutrient Sensing in Maternal-Fetal Resource Allocation1

The Impact of Maternal-Fetal Genetic Conflict Situations on the Pathogenesis of Preeclampsia

Placental Evolution within the Supraordinal Clades of Eutheria with the Perspective of Alternative Animal Models for Human Placentation

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