Maternal-Fetal Glucocorticoid Milieu Programs Hypothalamic-Pituitary-Thyroid Function of Adult Offspring

Slone-Wilcoxon, Jennifer; Redei, Eva E.

doi:10.1210/en.2004-0473

Cited by 34 publications

(26 citation statements)

References 24 publications

(24 reference statements)

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“…An interaction between the HPT and HPA axes functions has been recognized in adult animals and humans (11,22); glucocorticoid treatment during pregnancy produces HPT axis dysfunction and conversely, TH regulate HPA axis maturation (22,47,48). In humans, survivors of childhood abuse show altered serum TSH and T 3 /T 4 levels (49).…”

Section: Discussionmentioning

confidence: 99%

Neonatal Maternal Separation Alters, in a Sex-Specific Manner, the Expression of TRH, of TRH-Degrading Ectoenzyme in the Rat Hypothalamus, and the Response of the Thyroid Axis to Starvation

et al. 2016

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Hypothalamic-pituitary-thyroid (HPT) axis activity is important for energy homeostasis, and is modified by stress. Maternal separation (MS) alters the stress response and predisposes to metabolic disturbances in the adult. We therefore studied the effect of MS on adult HPT axis activity. Wistar male and female pups were separated from their mothers 3 h/d during postnatal day (PND)2-PND21 (MS), or left nonhandled (NH). Open field and elevated plus maze tests revealed increased locomotion in MS males and anxiety-like behavior in MS females. At PND90, MS females had increased body weight gain, Trh expression in the hypothalamic paraventricular nucleus, and white adipose tissue mass. MS males had increased expression of TRH-degrading enzyme in tanycytes, reduced TSH and T3, and enhanced corticosterone serum concentrations. MS stimulated brown adipose tissue deiodinase 2 activity in either sex. Forty-eight hours of fasting (PND60) augmented serum corticosterone levels similarly in MS or NH females but more in MS than in NH male rats. MS reduced the fasting-induced drop in hypothalamic paraventricular nucleus-Trh expression of males but not of females and abolished the fasting-induced increase in Trh expression in both sexes. Fasting reduced serum concentrations of TSH, T4, and T3, less in MS than in NH males, whereas in females, TSH decreased in MS but not in NH rats, but T4 and T3 decreased similarly in NH and MS rats. In conclusion, MS produced long-term changes in the activity of the HPT axis that were sex specific; response to fasting was partially blunted in males, which could affect their adaptive response to negative energy balance.

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Section: Discussionmentioning

confidence: 99%

Neonatal Maternal Separation Alters, in a Sex-Specific Manner, the Expression of TRH, of TRH-Degrading Ectoenzyme in the Rat Hypothalamus, and the Response of the Thyroid Axis to Starvation

et al. 2016

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“…Each value is a mean  S.E. decrease of the maternal corticosterone level induces low plasma T3 levels in offspring [25]. The weight of the uterus in the estradiol-treated OVX offspring at 12 weeks of age was decreased by IBP exposure during gestation and lactation.…”

Section: Discussionmentioning

confidence: 99%

Maternal Isobutyl-Paraben Exposure decreases the Plasma Corticosterone Level in Dams and Sensitivity to Estrogen in Female Offspring Rats

et al. 2009

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ABSTRACT. Isobutyl-paraben (IBP), a widely used preservative in a variety of foods, shows high comparative binding affinity to estrogen receptors. Here, we examined the effects of maternal exposure of rats to IBP on plasma hormone concentrations and organ weights in dams, ratio of male pups, anogenital distance, organ weights and plasma hormone concentrations in offspring, puberty, estrous cycle and response of organ weight and plasma hormone concentrations to estrogen in adult female offspring, and reproductive and adrenal function in adult male offspring, all of which are under developmental estrogen regulation, to clarify the estrogenic effects of IBP during gestation and lactation on the endocrine systems of dams and offspring. While maternal exposure of IBP decreased the plasma corticosterone concentration and increased the uterus weight in dams and increased uterine sensitivity to estrogen in adult female offspring, the other indices examined were largely unaffected by the present treatment. Even though these results indicate little sign of endocrine disrupting effects for IBP, the existence of activity may be a matter of concern due to the possible impact on the health of future generations.KEY WORDS: corticosterone, estrogen, isobutyl-paraben, maternal, rat.J. Vet. Med. Sci. 71(8): 1027-1033, 2009 Parabens have been the most widely used preservatives for more than 50 years in a variety of food, cosmetic and pharmaceutical products [2,4,23] due to their broad spectrum of activity, inertness, low cost and long history of safe use. They have been detected in human urine collected from a demographically diverse group of male and female adults with no known exposure to parabens, suggesting that the majority of people have already been exposed to them [32]. Several studies indicate that exposure to parabens modulates the endocrine system and thus may have harmful consequences on animal and human health [4,7,13,22,28] because of the estrogenic activities of these compounds in vitro and in vivo [7,24], and anti-estrogenic activity in human skin has been shown [22]. In addition, exposure to parabens during adult periods has been implicated in reduction of the male reproductive system in rodents [7,19,20,21], whereas a recent study could not confirm these effects [10]. On the other hand, investigation of the effects of exposure to parabens during gestation to lactation is important because exposure to estrogenic chemicals during development could be a contributory factor in the rising incidence of endocrine dysfunction of offspring later in life [3,5,14,16,26]. But, the effects of early exposure to parabens are not consistent in previous reports [6,13,27,28]. Furthermore, the effects of early exposure to parabens on the endocrine system in adult female offspring, except for vaginal opening and intact uterus weight [13], are unclear. Therefore, we examined the effects of maternal exposure to parabens on several aspects of the endocrine system in male and female offspring, especially the effects on plasma hormone co...

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“…In pregnant female rats adrenalectomized on gestation day 8 there was a decrease in TRH mRNA, increase in serum TSH, and a decrease of T3 only in females [74]; it appears that maternal glucocorticoids determine the development of the hypothalamic-pituitary-thyroid axis in progeny.…”

Section: Thyroid Gland Function Under Impaired Adrenal Functionsmentioning

confidence: 90%

“…The study of deiodinase activities in human cell lines revealed that estradiol increased DIII activity in ECC-1 cells, dexamethasone inhibited DIII in WRL-68 cells only in the presence of fetal calf serum in the medium [59]. Dexamethasone in a dose-dependent manner decreased the stimulatory effect of T3 on ICAM-1 protein in human ECV 304 cells [74].…”

Section: Effect Of Stress On Peripheral Metabolism Of Thyroid Hormonementioning

confidence: 98%

Role of Glucocorticoids in Regulation of Iodine Metabolism in Thyroid Gland: Effects of Hyper-And Hypocorticism

Nadolnik¹

2012

Glucocorticoids - New Recognition of Our Familiar Friend

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Maternal-Fetal Glucocorticoid Milieu Programs Hypothalamic-Pituitary-Thyroid Function of Adult Offspring

Cited by 34 publications

References 24 publications

Neonatal Maternal Separation Alters, in a Sex-Specific Manner, the Expression of TRH, of TRH-Degrading Ectoenzyme in the Rat Hypothalamus, and the Response of the Thyroid Axis to Starvation

Neonatal Maternal Separation Alters, in a Sex-Specific Manner, the Expression of TRH, of TRH-Degrading Ectoenzyme in the Rat Hypothalamus, and the Response of the Thyroid Axis to Starvation

Maternal Isobutyl-Paraben Exposure decreases the Plasma Corticosterone Level in Dams and Sensitivity to Estrogen in Female Offspring Rats

Role of Glucocorticoids in Regulation of Iodine Metabolism in Thyroid Gland: Effects of Hyper-And Hypocorticism

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