Maternal, fetal and perinatal alterations associated with obesity, overweight and gestational diabetes: an observational cohort study (PREOBE)

Berglund, Staffan; García-Valdés, Luz; Torres-Espínola, Francisco J.; Segura, María Teresa; Martínez-Zaldívar, Cristina; Aguilar, María José Cuesta; Agil, Ahmad; Lorente, José A.; Florido, J.; Padilla, Carmen; Altmäe, Signe; Marcos, Acensión; López‐Sabater, M. Carmen; Campoy, Cristina

doi:10.1186/s12889-016-2809-3

Cited by 85 publications

(80 citation statements)

References 41 publications

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“…Self-reported pre-pregnancy BMI was inversely associated with cortisol. Some recent studies report similar findings (Berglund et al 2016;Stirrat et al 2014), and suggest this may underlie the association between higher BMI during pregnancy with macrosomia and prolonged gestation.…”

Section: Biological Factorssupporting

confidence: 58%

Determinants of cortisol during pregnancy – The ABCD cohort

Bleker

Roseboom

Vrijkotte

et al. 2017

Psychoneuroendocrinology

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Please cite this article as: Bleker, Laura S., Roseboom, Tessa J., Vrijkotte, Tanja G., Reynolds, Rebecca M., de Rooij, Susanne R., Determinants of Cortisol During Pregnancy − the ABCD Cohort.Psychoneuroendocrinology http://dx.doi.org/10. 1016/j.psyneuen.2017.05.026 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. later adverse health consequences. However, evidence linking maternal stress to maternal cortisol values during pregnancy is inconclusive. A possible explanation for this is that other maternal factors overshadow any potential effects of stress on cortisol levels. We studied a large cohort of pregnant women with extensive data on pregnancy characteristics to determine the respective contributions of biological, environmental and psychosocial stress factors to cortisol levels in pregnancy. Methods:We used data from 3039 women from the Amsterdam Born Children and their Development-study cohort. Serum cortisol was measured in blood, collected at the first prenatal visit, at different gestational ages (median=91 days, range=40-256 days), and at various time points during the day (median=11:45h, range=08:00 -18:30h). We assessed associations between maternal serum cortisol in pregnancy and biological factors, lifestyle factors and stress factors, including depression, anxiety, pregnancy-related anxiety, work stress, parenting stress and fatigue. Results:In multivariable analysis, variables that were associated with higher cortisol levels in pregnancy were lower maternal age [1.5 nmol/l, 95%CI (0.6 to 2. Conclusions: Our data suggest that maternal cortisol during pregnancy is mainly affected by biological and lifestyle factors, but not by psychosocial factors. We suggest that psychosocial stress in Laura S. Bleker 3 pregnancy might program the fetus through other mechanisms than through altering maternal cortisol levels.

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Section: Biological Factorssupporting

confidence: 58%

Determinants of cortisol during pregnancy – The ABCD cohort

Bleker

Roseboom

Vrijkotte

et al. 2017

Psychoneuroendocrinology

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“…Because of the time span of our study data acquisition (1980-2015) some earlier GD cases might have been undiagnosed, particularly those occurring in 1980s. Even though epidemiological studies have reported a rising trend of GD, these studies must be interpreted with caution: the rising trends of GD may be due to better diagnostics (39)(40)(41)(42). Among women who reported having GD during pregnancy we observed higher percentage of A12C drugs (in majority these were magnesium preparations) and folate/ multivitamin supplement consumption, most likely in pursuit of minimising detrimental effects of GD with health promoting behaviour.…”

Section: Discussionmentioning

confidence: 75%

Characteristics of health behaviours and health status indicators among pregnant women in Slovenia

et al. 2017

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Navade, povezane z zdravjem in socialno demografske značilnosti nosečnic v Sloveniji tina kek,1 nataša karas kuželički,2 Irena Mlinarič raščan,2 ksenija Geršak 1,3 IzvlečekIzhodišča: Nosečnost je obdobje, ko ženske za zdravje bodočega otroka kritično presojajo in ocenjujejo svoje zdravje ter z zdravjem povezane navade. Skupaj z zdravstvenimi delavci se srečujejo s šte-vilnimi tveganji in odločitvami, ki postanejo veliko kompleksnejše, saj je v igri vpliv na dva organizma. Namen članka je pregled ter iskanje morebitnih povezav med zdravjem, z zdravjem povezanimi navadami ter socialno demografskimi dejavniki v nosečnosti, ki so jih poročale sodelujoče ženske.Metode: Podatke študije smo pridobili v okviru raziskovalnega projekta Analiza bioloških označe-valcev presnove folatov pri ugotavljanju tveganja za nastanek napak nevralne cevi, orofacialnih shiz ter prirojenih srčnih napak, ki je potekal od maja 2013 do septembra 2015. Vprašalnik o maternalnem zdravju, z zdravjem povezanih navadah ter socialno demografskih karakteristikah je izpolnilo 450 sodelujočih žensk. Podatki zajemajo nosečnosti, ki datirajo od osemdesetih let prejšnjega stoletja pa do leta 2015.Rezultati: Mlajše in manj izobražene ženske so pogosteje poročale o kajenju med nosečnostjo, medtem ko so starejše, bolj izobražene ter nulipare ženske v višjem odstotku jemale folatne/multivitaminske dodatke. Opazili smo U-obliko porazdelitve uporabe zdravil (brez recepta in na recept) glede na stopnjo izobrazbe. Najvišji odstotek uporabe so imele ženske z najvišjo stopnjo izobrazbe (magisterij/doktorat) in ženske z doseženo najnižjo stopnjo izobrazbe (osnovna šola). Večjo uporabo zdravil med nosečnostjo so poročale tudi starejše ženske. Opazili smo trend višanja uporabe zdravil in folatnih/multivitaminskih pripravkov kot tudi incidence nosečniške sladkorne bolezni preko preiskovanega obdobja, z najvišjo incidenco v zadnjih desetletjih. Višjo pojavnost kroničnih bolezni smo opazili v skupini multiparih žensk.Zaključki: V navadah povezanih z zdravjem nosečnic obstajajo precejšnje socialno demografske razlike. Za izboljšanje zdravja so potrebni izboljšani javno zdravstveni ukrepi in individualno svetovanje, da lahko ustrezno naslovimo specifične potrebe socialno demografskih skupin z višjim tveganjem za neželene izide nosečnosti. AbstractBackground: Pregnancy is a period when women reconsider their own health and health related behaviour for the sake of their future child. Along with their health providers, they are faced with a number of risk assessments and decisions, which become far more complex as their effect on two organisms rather than one is at play. This paper provides an overview of possible associations between self-reported health status, health behaviours and socio-demographics during pregnancy. 296zdrav vestn | julij -avgust 2017 | letnik 86 reProdukCIja človeka Methods: Study data were obtained from the case-control research project "Analysis of folate metabolism biomarkers in the risk assessment for neural tube defects, orofacial clefts and cong...

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“…También el estudio PREOBE describe mayores alteraciones maternas, cuando se presenta la obesidad, con aumento de peso del niño al nacer, así como prevalencia al sobrepeso y la obesidad en los primeros años de vida (27).…”

Section: Discussionunclassified

“…Una forma de prevención consiste en controlar el peso de la madre, antes y durante la gestación (27).…”

Section: Conclusiónunclassified

Obesidad durante el embarazo y su influencia en el sobrepeso en la edad infantil

Aguilar-Cordero¹,

García²,

Sánchez-López³

2016

Nutr Hosp

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Key words:Maternal obesity. Breastfeeding. Childhood obesity. AbstractIntroduction: Obesity has become a chronic disease which prevalence is increasing exponentially in countries developed. Pregnant women with a higher body mass 30 kg/m² index have higher risk of complications during pregnancy, childbirth and postpartum. Maternal obesity has negative consequences for the fetus, increasing the prevalence of macrosomia, decreasing breastfeeding and increased the risk of obesity childhood. Objective: The objective of this study is to determine if the prevalence of Childhood obesity is associated to weight gain during pregnancy and the breastfeeding stage. Methodology: The design of this study is retrospective descriptive. It has been done in the city of Granada (Spain) between the months of October 2014 and June 2015. The study estimated a universe of 500 children from 8 to 12 years with overweight. The sample consisted of 54 children, all of them with overweight or obesity. Results: For the study there were included 27 boys and 27 girls. The average age was 10.65 ± 1.38 years, with an average weight of 66.05 kilos and an average size of 150.75 cm, equivalent to a mean BMI of 28.60.The Mothers studied gained an average of 16.17 kg of weight during pregnancy and only 2.83 months of breastfeeding on average. Conclusion: The excess of weight during pregnancy and decreased breastfeeding are related to child obesity at the age of 10.The prevention of obesity in children and adolescents should be prevented from pregnancy. One way of prevention could be the weight control of the mothers during pregnancy. It is also important to support the first days of postpartum for the establishment of breastfeeding in women with obesity, due the fact that they delay the lactogenesis.

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Maternal, fetal and perinatal alterations associated with obesity, overweight and gestational diabetes: an observational cohort study (PREOBE)

Cited by 85 publications

References 41 publications

Determinants of cortisol during pregnancy – The ABCD cohort

Determinants of cortisol during pregnancy – The ABCD cohort

Characteristics of health behaviours and health status indicators among pregnant women in Slovenia

Obesidad durante el embarazo y su influencia en el sobrepeso en la edad infantil

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